COVER STORY: MIBELLE BIOCHEMISTRY ADVERTISEMENT FEATURE R
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Dual exosome power for skin rejuvenation
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The potential of exosomes for the cosmetic field has become increasingly clear over the past years. Exosomes are a type of extracellular vesicles with a size of 30-200 nm containing lipids, RNAs, proteins, and metabolites. Released by one cell to initiate a response in another cell, they are important players of cellular communication. Thus, signaling via exosomes plays a major
role in many cellular processes. In the skin, for instance, mesenchymal stem cells, precursors of different cell types, are essential for regeneration processes, such as wound healing. Interestingly, mesenchymal stem cells themselves are not needed for this process, but rather the exosomes that they secrete to communicate with other cells.
The potential of plant exosomes As is the case with mammalian cells, plant cells use extracellular vesicles to transfer RNAs, proteins, lipids, and secondary metabolites. Such plant-derived exosome-like nanovesicles (‘plant exosomes’) function in intercellular communication, the plant’s defense system or cell wall organization. Interestingly, plant-derived exosomes can
be taken up by mammalian cells and have a beneficial effect on human health through cross- kingdom cell communication. Due to their high stability and safety, plant-derived exosomes are a promising alternative to human- or animal- derived exosomes and thus have great potential for cosmetic applications.
A goji plant stem cell extract with dual exosome power Cultivated plant stem cells are an ideal source
PhytoCellTec™ Exosomes 1 Plant exosomes from the outside Keratinocyte August 2025 GLOBAL INGREDIENTS l FORMULATION l
of the stratum corneum to improve the function of the skin barrier, goji stem cell extract protects the skin from water loss and external aggressors, such as UV or pollution. Especially aged skin, tends to have an impaired barrier function and a reduced ability to recover, and can be well supported and protected by PhytoCellTec™ Exosomes.
of plant exosomes. PhytoCellTec™ Exosomes (INCI: Lycium Barbarum Callus Culture Extract (and) Isomalt (and) Lecithin (and) Aqua / Water) is based on an extract from a plant stem cell culture originally derived from a goji seedling naturally containing exosomes. The exosomes were analyzed by dynamic light scattering and transmission electron microscopy. The data confirmed intact exosomes enclosed
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Strenghtens the skin barrier
by a double-layer membrane with a size of approximately 200 nm. Goji (Lycium barbarum) plants are native to Southeast Europe and Asia and their fruits, the goji berries, are one of the most famous superfruits. The PhytoCellTec™ technology developed by Mibelle Biochemistry is based on callus culture to sustainably produce biomass.
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Exsomes from the inside Mesenchymal stem cell
Fibroblast
Promotes collagen and elastin production Improves Density
Figure 1: Dual function of PhytoCellTec™ Exosomes delivering plant exosomes to the skin from outside (1) and stimulating the release of endogenous exosomes from mesenchymal stem cells inside the skin (2) to protect and rejuvenate the skin
www.personalcaremagazine.com
Plant exosomes from outside to protect the skin The effect of the plant-derived exosomes in PhytoCellTec™ Exosomes on the skin was assessed in keratinocytes treated with 0.1% goji stem cell extract for 24 hours. The treatment increased the expression of genes involved in the late epidermal differentiation and cornification process. Thus, by supporting the formation
Boosting the release of exosomes inside the skin for rejuvenation In addition, based on several in vitro studies, it was shown that the PhytoCellTec™ Exosomes can boost the exosome secretion by mesenchymal stem cells in the skin and thereby improve communication with fibroblasts via exosomes. This results in the increased production of extracellular matrix components such as collagens, elastin, and enzymes important for collagen production (PLOD1) and the linkage of collagen and elastin (LOX).
Dual exosome-based mechanism to reshape the face and breasts This dual function based on exosomes – delivery of plant exosomes and boosting of the endogenous exosome production – leads to skin protection and rejuvenation. The effect was confirmed in three clinical placebo-controlled studies in which volunteers applied a cream containing 0.4% PhytoCellTec™ Exosomes or a placebo twice daily for either 28 or 56 days. Treatment with PhytoCellTec™ Exosomes
significantly reduced wrinkle depth and increased skin density. It visibly improved fine lines and wrinkles and the oval shape of the face. Moreover, PhytoCellTec™ Exosomes can reduce breast sagging, induce breast lifting, and increase skin elasticity in the breast area. Therefore, PhytoCellTec™ Exosomes due to its
dual exosome-based mechanism has a clinically proven effect on skin sagging and reshaping of facial contours and breasts.
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Mibelle AG Biochemistry 5033 Buchs / Switzerland Tel: +41 62 836 17 31 Web:
www.mibellebiochemistry.com
August 2025 PERSONAL CARE
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