NATURALS 53 Collagen IV n Nuclei n Collagen IV
Untreated Elastic fibers
Vehicle
0.5% Rootness Energize
1% Rootness Energize n Counterstain n Elastic fibers
Untreated Figure 2: Production of skin matrix core elements. A further study conducted on 44-year-old
fibroblasts using the seahorse technology revealed that 1% natural energy booster increases maximal respiration by 111%, spare respiration capacity by +147%, and ATP production by +63%. Bioenergetic cell parameters are protected and boosted so that cells can react to urgent energetic demand. In parallel, the natural energy booster’s capacity to activate endogenous defences was evaluated through transcriptomic and proteomic study to demonstrate its ability to protect the mitochondria against oxidative stress related to metabolic processes. In addition to the activation of metabolic
and energetic pathways, the capacity of the natural energy booster to support the synthesis of extracellular matrix components was also evaluated. Ex vivo, immunolabeling and staining of a 42-year-old’s skin explant with 1% natural energy booster showed an increase in the presence of collagen IV (that supports epidermis and dermis cohesion) and elastic fibres (that prevent loss of elasticity) after 7 days of contact (Fig 2). By boosting the metabolic pathways, cells
are recharged with the adequate amount of energy, supporting the skin matrix structure.
Day 0 Rootness Energize Day 62 Rootness Energize
Visibly improving skin parameters In a clinical trial conducted on 20 Caucasian women aged from 45 to 55 years old, with a lack of skin firmness and describing themselves as stressed, the natural energy booster at 1% in a formulation was applied twice daily in a half-face study and compared to a placebo. At 28 and 62 days, firmness, tonicity, elasticity and skin viscoelasticity were assessed. After 62 days, firmness had significantly increased by +20%, tonicity by +21%, and elasticity by +27%. In comparison, the placebo modified the same parameters by respectively +3%, +4% and +4.5%. Visible results were shown with Visia images (Fig 3).
Producing new natural active molecules locally: Plant Milking Technology While recently launched active ingredients for skin care are obtained from exotic plants or deep-sea organisms, there is an alternative and more local way to source rare and powerful molecules: the plant roots. As they grow in the ground, a harsh environment where they are subject to a large variety of aggressions, plant roots have
Day 0 Placebo
Day 62 Placebo
developed specific defence mechanisms such as the production of original secondary metabolites that are not found in the other parts of the plant. These metabolites possess biological activities that have been used for centuries by humans, through traditional medicine and more recently to create drugs. But to get access them, it was necessary to uproot the plant from the soil, which lead to its destruction and could not be applied to sustainable industrial production. A French biotech company developed Plant Milking Technology, an innovative process to grow roots in aeroponic conditions so that they are directly accessible and can be stimulated to produce targeted active molecules with specific nutritive solutions. Starting from seeds purchased in compliance with the Nagoya protocol, grown under controlled conditions to ensure a regular quality of the production, and harvested and extracted directly on the production site, the extracts obtained via Plant Milking Technology are made in France, 100% traceable, and safe.
Conclusion Rootness Energize is one of the extracts obtained by this technology, applied to the plant called Luffa cylindrica. Its roots contain rare bryonolic acid whose concentration, thanks to specific stimulation, can be multiplied by 10 compared to traditional Luffa cylindrica roots. This sustainable and local sourcing,
Figure 3: Visia image of volunteer 22. November 2020
associated with high levels of performance, makes Rootness Energize an ingredient of choice for formulators who are developing new skin care products to support consumers affected by a changing way of life and who need to recharge their skin’s cellular batteries.
PC PERSONAL CARE EUROPE
Vehicle
0.5% Rootness Energize
1% Rootness Energize
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