18 HYGIENE


Carboxylic Acid and Hexeth-4 Carboxylic Acid), there is even synergy, so less cationic biocide is needed to prevent microorganism growth.23 Additives of Oxidet L-75C


(Cocamidopropylamine Oxide) and foam booster Levenol H&B (Glycereth-2 Cocoate) allow formulating the foaming hand sanitiser, mild to the skin Table 5. The broadening biocide effect of Tetranyl BC-50 is attained by Tetranyl U, cationic derivative of undecylenic acid.


Conclusion At present, sanitising gels and non-aerosol instant foams are the most dynamically growing categories of hand sanitisers. The examples of various formulation methods presented here are intended to reflect current trends in antiviral hand protection when there is no water and soap nearby. In fact, for some half a year, the segment of leave-on hand sanitisers has turned into a huge and very branded market, where mass-market products complemented to niche, premium, and luxury. But perhaps this is a topic for a separate review. With more frequent use of sanitisers and soaps around the world, there has been a marked increase in demand for hand care products specifically designed for dry and irritated skin. Part 2 of our review will be devoted to this topic too.


PC


References 1 Roser M, Ritchie H, Ortiz-Ospina E, Hasell J.


Statistics and Research. Coronavirus Pandemic (COVID-19). Updated daily. URL: https://ourworldindata.org/coronavirus.


2 Coronavirus disease (COVID-19) advice for the public, URL: https://www.who.int/emergencies/diseases/no vel-coronavirus-2019/advice-for-public.


3 Fact Sheet COVID-19 Disease (SARS-CoV-2 virus), Version 6, Sciensano, 21 September 2020,48 pp.; https://covid- 19.sciensano.be/sites/default/files/Covid19/C OVID-19_fact_sheet_ENG.pdf.


4 Cascella M, Rajnik M, Cuomo A, Dulebohn SC, Di Napoli,R. Features, Evaluation and Treatment Coronavirus (COVID-19). StatPearls Publishing, URL: https://www.ncbi.nlm.nih.gov/books/NBK5547 76/ (Last Update: April 6, 2020).


5 Kim J-M, Chung Y-S, Jo HJ, Lee NJ, Kim MS, et al. Identification of coronavirus isolated from a patient in Korea with COVID-19. Osong Public Health & Research Perspective 2020; 11: 3-7


6 Li F. Structure, function, and evolution of coronavirus spike proteins. Annual Review of Virology 2016; 3: 237-261.


7 a) Hand Sanitizer Market – Global Outlook and Forecast 2020-2025; URL: https://finance.yahoo.com/news/global-hand- sanitizer-market-grow-140000818.html; b) Hand Sanitizer Market by Product, End Use,


PERSONAL CARE EUROPE O Figure 4: Phospholipid-like structure of Arlasilk PTM.


Table 5: Guideline formula of alcohol-free foaming hand sanitizer (C-189, Kao).


Composition Oxidet®


Levenol® Tetranyl® Tetranyl® %


L-75C H&B U


BC-501 Deionized Water


(1) 0.2% of Tetranyl® by 0.125% of Tetranyl®


3.0 1.0 0.6 0.2


Up to 100%


BC-50 can be substituted BC-80


Distribution Channel, and Regions, Global Industry Analysis, Market Size, Share, Growth, Trends, and Forecast 2020 to 2027, Fior Markets (2020); URL: https://www.globenewswire.com.


8 WHO Guidelines on Hand Hygiene in Health Care, First Global Patient Safety Challenge, World Health Organization, Geneva, 2009, 270 pp.


9 Clean Care is Safer Care Guide to Local Production: WHO-recommended Handrub Formulations, World Health Organization, April 2010, 9 pp.


10 Topical Antiseptic Products: Hand Sanitizers and Antibacterial Soaps, March 26, 2020. URL: https://www.fda.gov/drugs/information-drug- class/topical-antiseptic-products-hand- sanitizers-and-antibacterial-soaps.


11 Temporary Policy for Preparation of Certain Alcohol-Based Hand Sanitizer Products During the Public Health Emergency (COVID-19), Guidance for Industry. U.S. Department of Health and Human Services, Food and Drug Administration, Center for Drug Evaluation and Research (CDER), March 2020, Updated April 15, 2020, 15 pp.


12 Kratzel A, Todt, D, V’kovski, P, et al. Inactivation of severe acute respiratory syndrome coronavirus by 2 WHO-recommended hand rub formulations and alcohols, Emerging Infection Diseases 2020; 26(7).


13 Canchi DR, Garcia, A.E. Cosolvents effects on protein stability, Annual Review of Physical Chemistry 2013; 64: 273–293


14 a) Formulating Hydroalcoholic Gels with Carbopol Polymers, Tech. Report TDS-255, Lubrizol Corporation: Wickliffe, OH, USA, 2009, 6 pp.; b) Neutralizing Carbopol and Pemulen Polymers in Aqueous and Hydroalcoholic Systems, Tech. Report TDS- 237, Lubrizol Corporation: Wickliffe, OH, USA, 2009, 3 pp.


15 DEB IP, Ltd. High alcohol content foaming compositions with silicone-based surfactants, EP 3292757 A1, 2006/2018.


16 Grayson ML, Kirsa SW, Shilson AD. Topical composition, US Pat. Appl. 2010/0029780 A1, 2005/2010.


17 Carli, B. Organic hand sanitizing gel, Posted on June 18, 2020. URL: https://knowledge.ulprospector.com/10660/pc c-organic-hand-sanitizing-gel/.


18 Tea Tree Oil and the SARS-CoV-2 Coronavirus Pandemic, Document of the Australian Tea Tree Industry Association, May 15, 2020, 4 pp.


19 Davies B. Surfactant–biocide interactions, in: Recent Developments in the Technology of Surfactants (Crit. Rep. Appl. Chem., 30), Ed. by M.R. Porter, Elsevier Science Publishing, New York, 1990, pp. 65-131.


20 Pletnev M. Green and natural surfactants: recent developments, SOFW Journal 2006; 132 (6): 2-12.


21 Salvatico S, Pereira D, Feuillolay C, Bégeault N, Roques C. Chlorhexidine digluconate formulations used for skin antisepsis, Open Journal of Medical Microbiology 2019; 9: 95-104


22 Eggers M, Koburger-Janssen T, Ward LS, Newby C, Müller S. Bactericidal and virucidal activity of povidone-iodine and chlorhexidine gluconate cleansers in an in vivo hand hygiene clinical simulation study, Infectious Diseases & Therapy 2018; 7: 235–247


23 Akypo: The Toughest Cleaners with the Softest Touch, Booklet, Kao Corporation, S.A., 2012, 11 pp.


November 2020 O CI-


N H


+ N


H N


N +


CI- O O OH P OH O O- Na+


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80