24 UHPLC System Designed to Enhance Many Biopharmaceutical Applications
Thermo Fisher Scientific is pleased to introduce the Thermo Scientific™ Dionex™ UltiMate™ 3000 Biocompatible Rapid Separation (BioRS) system, designed to bring highly flexible UHPLC separation capabilities to a wide range of biopharmaceutical research and QA/QC analyses.
The UltiMate 3000 BioRS system has an extensive selection of modules that supports high resolution separations for R&D and also high throughput analyses for QA/QC on the same platform, at pressures up to 15,000 psi. Options include wide selections of pumps, detection techniques, fraction collectors, and autosamplers. The platform is designed for easy method transfer between different stages of pharmaceutical product development and production.
Thermo Fisher Scientific offers dedicated bio UHPLC consumables that help the UltiMate 3000 BioRS system perform quickly and well in a variety of modes, including those requiring harsh solvents. These include gold standard Thermo Scientific™ ProPac WCX protein columns for QA/QC, UHPLC ion-exchange columns, and a wide range of mixed mode and HILIC columns.
Biocompatible capillaries with the Thermo Scientific™ Dionex™ Viper™ Fingertight fitting system are designed for rugged, virtually dead-volume-free connections.
MORE INFO. 58
How Flexibility and Process Economics Can be Combined in one LC System
This question was the starting point for developing a new type of preparative liquid chromatography equipment for purification tasks. Contichrom®
process equipment from Knauer successfully combines the flexibility of batch HPLC systems with the efficiency and
throughhput of continuous chromatography systems. Contichrom®
is a preparative 2-column liquid chromatography system, designed for discovery, process development, and scale-up. The system offers great flexibility for all process choices (batch, SMB, MCSGP, multi-column) with a single equipment and control software.
Compared with other LC purification systems Contichrom doesn’t need large screening efforts for process development and optimisation. Instead you can start from a simple non-optimised batch process and easily switch to a superior countercurrent solvent gradient purification (MCSGP) process. This is made possible by the user-friendly Contichrom®
lab control software.
The MCSGP process principle works with two columns rather than one. Through continuous column switching, impure side fractions, containing product are recycled internally, thus maximising extraction of the product. Yield and purity can be increased by 50%, while achieving up to 10-times higher throughput and a 70% reduction in solvent or buffer consumption.
MORE INFO. 59
ADVERTORIAL Total Nitrosamines Analysis System
In certain production processes such as those in cosmetics or agricultural pesticides industries, it is important to analyse for the presence of Nitrosamines, but it is not all ways essential to know the exact profile of the nitrosamine species.
New 2013 800 Series TEA
Nitro, Nitroso & Nitrogen Detector
Improved Limits of Detection New Selectable Time Constant Filters
Improved Performance for High Flow Applications Improved Ozone Control Linear Response
Interface with most GCs
The Ellutia Chemical Stripping System has been developed to be used in unison with an 800 Series TEA to perform total nitrosamine analysis. Instead of using a pyrolyser to heat the nitrosamine to remove the NO group, a chemical reaction can be employed. The alleviation of NO from the nitrosamine is performed by a reflux reaction with hydrobromic acid in ethyl acetate. The nitrosamine sample is injected into the reaction vessel and produces NO, a secondary amine and bromine. The NO is then carried in a gas stream through a cold trap (removing any vapour) to the TEA
For further information please visit:
www.ellutia.com/
TotalNitrosamines.html MORE INFO. 60
New 2013 Spec 800 Series TEA The TEA (Thermal Energy Analyser) has been an industry
standard for explosives and nitrosamine analysis since its introduction thanks to its incredible sensitivity and almost infinite selectivity for nitrogen containing compounds. Ellutia have updated the 800 Series TEA for 2013. A number of improvements have been implemented to further improve the class leading detection limits.
Application Areas
Nitrosamines in Rubber Nitrosamines in Water
Tobacco Specific Nitrosamines Alkyl Nitrates in Air
Nitrogen Pesticides
Nitrosamines in Cosmetics Explosives Analysis
Nitrosamines in Brewing Chromatography Solutions Web:
www.ellutia.com Email:
info@ellutia.com MORE INFO. 61 Scan
Newly designed internal plumbing allows for greater sample flow rates whilst maintaining a high vacuum. This dramatically improves the performance of the instrument with high flow rate applications such the use of packed, wide bore columns, or with a glassware chemical stripping system. New selectable time constant filters allow the user to tune the TEA depending upon their peak width, to improve sensitivity by reducing the signal to noise ratio.
These improvements mean that all 800 Series TEAs now achieve a detection limit of at least 800 femtograms of Nitrogen per second on the factory acceptance test of NDMA.
All 800 Series TEAs now ship with this new specification as standard, but users of older 800 Series TEAs do not have to go with out. Older model 800 Series TEA’s can be updated to the latest 2013 specification by Ellutia.
For further information please visit:
www.ellutia.com/
800TEA.html MORE INFO. 62
INTERNATIONAL LABMATE - JANUARY/FEBRUARY 2013
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