58 HAIR CARE
30 25 20 15 10 5 0
-5 -10 1 2 3 4 Month 5 6 * * *
60 50 40 30 20 10 0
-10 -20
1 2 3 4 Month 5 6 * * ** *
20 15 10 5 0
-5 -10 1 2 3 4 Month **p< 0.01, *p<0.05 vs. -/+ (Student t-test). Values indicate the mean±SE.
Figure 6: Hair parameters of the clinical study
volunteers.The active group showed higher effects than the placebo group, which was significant on total hair number (17.8 ± 4.81 vs. 1.19 ± 5.75; active vs. placebo; /cm2
) at 4 months, and growth rate (31.3 ± 10.7 vs. 0.0926 ± 10.9; active vs. placebo; μm/day) and thickness (8.16 ± 0.907 vs. -2.39 ± 1.36; active vs. placebo; μm) at 3 months.
“Burgeon-Up” - was developed. It is expected to promote secretion of RSPO1 from DP cells and promote hair growth. In vitro data showed that Nasturtium officinale Leaf/Stem Extract not only increased the secretion of RSPO1 and increased the Wnt activity even with the presence of DHT, but also inhibited the secretion of the hair loss factor DKK1 related to AGA. The result of the ex vivo and clinical test also confirmed the efficacy of Nasturtium officinale Leaf/Stem Extract. The ingredient was one of the finalists at
in-cosmetics Asia 2019 Active Ingredient category and won the silver award at the recent BSB Innovation Award 2020 in the natural product for scalp, hair, moisture and tan raw material category.
PC 0 month (baseline)
References 1 Springer K, Brown M, Stulberg DL. Common hair
loss disorders. Am Fam Physic. 2003; 68(1):93-102.
2 Madaan A, Verma R, Singh AT, Jaggi M. Review of hair follicle dermal papilla cells as in vitro screening model for hair growth. Int J Cosmet Sci. 2018; 40: 429−450.
3 Driskell RR, Clavel C, Rendl M, Watt FM. Hair follicle dermal papilla cells at a glance. J. Cell Sci. 2011; 124:1179–1182.
4 Kishimoto J, Burgeson RE, Morgan BA. Wnt signaling maintains the hair-inducing activity of the dermal papilla. Genes & development. 2000; 14: 1181-1185
5 de Lau W, Peng WC, Gros P, Clevers H. The R- spondin/Lgr5/Rnf43 module: regulator of Wnt signal strength. Genes Dev. 2014; 28: 305–316. 6 Li N, Liu S, Zhang HS, Deng ZL, Zhao HS, Zhao Q,
3 months
et al. Exogenous R-Spondin1 Induces Precocious Telogen-to-Anagen Transition in Mouse Hair Follicles. Int. J. Mol. Sci. 2016; 17: 582.
7 Jaks V, et al. Lgr5 marks cycling, yet long-lived, hair follicle stem cells. Nat Genet.2008; 40(11): 1291-1299.
8 Binnerts M, Kim K, Bright J, Patel S, Tran K, Zhou M, et al. R-Spondin1 regulates Wnt signaling by inhibiting internalization of LRP6. Proc. Natl Acad.
Sci.USA. 2007; 104: 14700–14705.
9 Catherine E, Ulbricht. Natural Standard Herb & Supplement Guide: An Evidence-Based Reference. Elsevier/Mosby, Maryland Heights, USA, 2010; 758-759.
10 Kwack MH, Sung YK, Chung EJ, et al. Dihydrotestosterone-inducible dickkopf 1 from balding dermal papilla cells causes apoptosis in follicular keratinocytes. J. Invest. Dermatol. 2008; 128: 262–269.
5 6 ** ** ** **
Figure 7: Phototrichogram analysis of an active group volunteer at 0 month (left) and 3 months (right). 0 month (baseline) 3 months 6 months
Figure 8: Visual change of hair volume from a 51 year old volunteer from 0 month, 3 months and 6 months (left to right). PERSONAL CARE EUROPE June 2020
Total hair number /cm2
Hair growth rate µm/day
thickness, µm
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