ANTI-AGEING 23 a


120 100 80 60 40 20 0


Normal cells


SIPS cells


b


-24% ***


120 100 80 60 40 20 0


SIPS cells Scutaline (0.075%)


Control +LPS c


-74% ***


120 100 80 60 40 20 0


+LPS


Scutaline (0.25%)


Figure 3: Scutaline prevents inflamm’aging. a) NHDF were exposed to H2


the absence of Scutaline. The amount of IL-6 secreted was measured using ELISA assay. b, c) LPS-activated macrophages were cultivated in the presence or in the absence of Scutaline for 24h. The productions of NO (b) and PGE2 ***p-value<0.001


for 2h and then left for 3 days. Cells were then cultivated in the presence or in (c) were measured using spectrophotometry and ELISA assay respectively.


O2


radicals which maintains the inflammatory reaction and rich in PGE2


that may cause


pain, redness and/or oedema. The treatment with Scutellaria


baicalensis root extract (0.075%) leads to a 24% decreased in the amount of IL-6 produced by senescent fibroblasts. Furthermore, in the presence of Scutellaria baicalensis root extract (0.25%), activated macrophages produce 74% and 82% fewer NO and PGE2


respectively. Taken together these data suggest that


Scutellaria baicalensis root extract is capable of decreasing the senescence-induced inflammation by reducing the number of recruited macrophages and by decreasing the severity of any unspecific response from activated macrophages. Scutellaria baicalensis root extract may therefore reduce local pain, redness and oedema. This curative effect may thus limit


inflamm’aging in more mature skins and support them in the well-ageing process.


Benefits for the skin By ensuring an optimal activity to skin cells and by preventing chronic low-grade inflammation, Scutellaria baicalensis root extract may therefore be a good candidate for topic pre-ageing or anti-ageing treatments. In order to assess Scutellaria baicalensis


root extract’s anti-ageing properties, 20 female volunteers received a treatment with Scutaline (2%) applied twice a day on the face for 28 days.


Control +LPS


-82% ***


+LPS


Scutaline (0.25%)


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PERSONAL CARE EUROPE


IL-6 secreted (% of SIPS)


No production (% of LPS)


PGE2


production (% of LPS)


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