24 ANTI-AGEING The volunteers were divided into two
groups: “prevention group” (aged 40-50) in order to assess Scutellaria baicalensis root extract’s ability to prevent ageing, and a “correcting group” (aged 51-68) in order to assess Scutellaria baicalensis root extract ability to correct the effects of ageing. Several key parameters of the skin were instrumentally measured and assessed by a dermatologist and by the volunteers themselves. All the assessed skin parameters were
improved in both groups. In the Prevention Group, skin hydration
was quickly increased, skin redness was steadily improved, and skin biomechanical properties were improved by the end of the treatment. This is consistent with the clinical evaluation. Indeed, the patients observed most of the benefits after only 14 days of treatment, especially for comfort parameters such as hydration, skin tone and softness. As for the skin firmness, skin elasticity and wrinkles were also improved but in a more time dependent way (Fig 4A). In the Correction Group, skin hydration
was quickly increased, skin redness reached a plateau after only 14 days and skin firmness and elasticity were steadily increased. The patients that received the treatment observed that the comfort parameters were strongly improved after only 14 days of treatment while the anti- ageing benefits (skin firmness, elasticity and wrinkles) were slightly delayed when compared to the Prevention Group (Fig 4B). Treatment with Scutellaria baicalensis
root extract thus globally improves the skin with quicker benefits for skin tone, hydration and softness. The processes that require a biological and/or biomechanical effect such as firmness, elasticity or wrinkle reduction are also improved at the end of the treatment but require a longer time (Fig 4).
Conclusion Senescent cells are responsible for generating a local inflammation while also spreading senescence to other nearby or far away cells. This transmission process may lead to inflamm’aging, a chronic inflammation that causes skin premature ageing (dehydration, wrinkles, sagging of facial muscle, pigmentary disorders, loss of radiance, etc.). Scutaline (INCI name: Scutellaria
baicalensis root extract) is a cosmetic active capable of fighting senescence in a dual way. It is able to prevent healthy skin cells from becoming senescent after an exposure to a stress (oxidative stress, UV, pollution…), and it is able to reduce the negative impact of already senescent cells on their environment while preserving their beneficial effects (senescent cells still produce collagen (although in reduced quantity) and contribute to the extracellular
PERSONAL CARE EUROPE a
12 10 8 6 4 2 0
Hydration Redness Firmness Elasticity b
18 16 14 12 10 8 6 4 2 0
Hydration Redness Firmness Elasticity n T14 n T28 Hydration Uniformity Firmness
6 5 4 3 2 1 0
Softness Uniformity Hydration Radiance Firmness
6 5 4 3 2 1 0
Softness
Radiance
Elasticity Wrinkles
General aspect
Elasticity Wrinkles n T0 n T14 n T28
Figure 4: Scutaline improves skin parameters in human volunteers. Instrumental measure (top) of the improvement (expressed in % vs T0) of skin firmness, elasticity (cutometry), hydration (corneometry) and redness (VISIA), and clinical scoring (bottom) of several skin parameters by self-evaluation using a scoring method: 1 Very bad ; 2 Moderately bad ; 3 Slightly bad ; 4 Slightly good ; 5 Moderately good ; 6 very good a) Prevention group. b) Correction group.
matrix biomechanical features. Scutaline thus allows for a quick
reduction of inflammation that leads to a decrease of redness and pain and to an increase in skin hydration and comfort. Furthermore, Scutaline ensures the normal activity of skin cells (collagen production…) for a skin with optimal biomechanical properties such as firmness and elasticity. Scutaline protects against senescence in
young skin. Scutaline also limits the effects of inflamm’aging on mature skin. Therefore, by providing preventive and curative benefits, Scutaline may be a good candidate for supporting the skin during the ‘well-ageing’ process.
PC
References 1 Ghosh K, Capell BC. The Senescence-
Associated Secretory Phenotype: Critical Effector in Skin Cancer and Aging. J Invest Dermatol. 2016;136(11):2133-2139.
2 McHugh D, Gil J. Senescence and aging: Causes, consequences, and therapeutic avenues, J Cell Biol. 2018; 2;217(1):65-77.
3 Shimizu T, Shibuya N, Narukawa Y, Oshima N, Hada N, Kiuchi F. Synergistic effect of baicalein, wogonin and oroxylin A mixture: multistep inhibition of the NF-κB signalling pathway contributes to an anti-inflammatory effect of Scutellaria root flavonoids, J Nat Med. 2018;72(1):181-191.
4 Vomund S, Schäfer A, Parnham MJ. Brυne B, von Knothen A. Nrf2, the master regulator of antioxidative stress. Int. J. Mol. Sci., 2017; 18: 2772
5 Yan JJ, Du GH, Qin XM, Gao L. Baicalein attenuates the neuroinflammation in LPS- activated BV-2 microglial cells through suppression of pro-inflammatory cytokines, COX2/NF-κB expressions and regulation of metabolic abnormality. Int Immunopharmacol. 2020 Feb;79:106092
6 You KM, Jong HG, Kim HP. Inhibition of cyclooxygenase/lipoxygenase from human platelets by polyhydroxylated/methoxylated flavonoids isolated from medicinal plants. Arch Pharm Res. 1999;22(1):18-24.
7 Song X, Yao J, Wang F, et al. Wogonin inhibits tumor angiogenesis via degradation of HIF-1α protein. Toxicol Appl Pharmacol. 2013;271(2):144-55
8 Xu D, Tahara H. The role of exosomes and microRNAs in senescence and aging. Adv Drug Deliv Rev. 2013;65(3):368-75.
9 Urbanelli L, Buratta S, Sagini K, Tancini B, Emiliani C. Extracellular Vesicles as New Players in Cellular Senescence. Int J Mol Sci. 2016; 26;17(9)
10 Terlecki-Zaniewicz L, Lämmermann I, Latreille J, et al. Small extracellular vesicles and their miRNA cargo are anti-apoptotic members of the senescence associated secretory phenotype. Aging (Albany NY). 2018;10(5):1103-1132
June 2020
General aspect
Improvement vs T0 (%)
Improvement vs T0 (%)
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