Laboratory Products 59 Straightforward Protein Characterisation at the NKI


Researchers at the Netherlands Cancer Institute (Nederlands Kanker Instituut, NKI) are benefiting from the advanced, multi-parameter characterisation offered by Avacta Analytical’s Optim®


technology for the study of novel proteins. Dr Anastassis Perrakis, Principle Investigator in


the Institute’s Structural Biology Group, explained: “We are interested in the mechanisms controlling a variety of different cellular processes, using in vitro protein characterisation to look at how proteins interact with other proteins and DNA. In addition to traditional biochemical assays, we perform a large number of biophysical experiments to help us understand these molecular interactions, and first became interested in the Optim instrument when we were having trouble measuring the melting curve for a particular protein of interest.”


The Optim instrument allows the Group to probe multiple protein stability-indicating parameters at high speed, using ultra-low sample volumes of proteins and other molecules. “We have had the instrument since May, and it has been very useful,” Anastassis continued. “It looks directly at the unfolding process through the physical properties of the protein – you do not need to use a reporter system – so the results are more precisely defined. The melting point data offers us a good indication of the quality of the proteins we express, as well as ensuring that they are stable and ‘happy’ under the conditions we plan to use in our biochemical assays, without excessive denaturation or aggregation. The biggest advantage for us is that the Optim instrument uses between 10 and 50 times less sample than competitive techniques, which is obviously a real benefit for downstream studies.”


27614pr@reply-direct.com Helium Recovery Units Provide the Perfect Technology for Reducing Costs


Helium test gas is an essential part of customised leak detection systems. It is a non-renewable, limited supply commodity with costs increasing yearly due to growing demands for higher quality parts in many industries. In order to design processes that are as efficient and resource-conserving as possible, Pfeiffer Vacuum has developed helium recovery units which make it possible to recover and recycle the gas used in leak detection.


The recovery of used helium is particularly useful for meeting the environmental certification requirements under DIN EN ISO 14001 and for saving resources. The helium recovery units are designed as stand-alone systems and can recover helium test gas regardless of the leak detection system manufacturer.


Depending on the process parameters, up to 98% of the inert gas can be recovered with helium concentrations between 10% and 95%.


Two possible Pfeiffer Vacuum helium recovery systems are available: The balloon recovery and the tank recovery. In addition, special customised, alternative solutions can be provided upon request.


Pfeiffer Vacuum develops and manufactures leak detection systems for any facility requiring high throughput production when a tightness criteria of parts needs to be guaranteed. The company also provides a wide range of leak detectors using helium or hydrogen as tracer gas for a wide variety of applications.


27682pr@reply-direct.com


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