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Convergence Chromatography with the ACQUITY UPC2 Bring streamlined workflow, expanded selectivity, and an orthogonal technique to your laboratory.


™ System


Convergence chromatography (CC) is a broad-based, complementary analytical platform that is taking its place alongside of LC and GC as one of the three essential separation technologies for modern laboratory analysis. This technique provides another, reliable choice as an analytical platform that is orthogonal to reversed-phase LC (RPLC), while significantly streamlining the entire analytical workflow.


In convergence chromatography, the separation is achieved by manipulating the density and composition of a supercritical fluid-based mobile phase. Because of the very high diffusivity of the mobile phase, high separation efficiency can be achieved. Additionally, the diversity of stationary phase and mobile phase (co-solvent) options provides access to the largest selectivity space available to any separation technique.


The ACQUITY UPC2 System is a holistically designed CC system that utilises liquid CO2 as the primary mobile phase. The system leverages the chromatographic principles


and selectivity of normal-phase chromatography while providing the ease-of-use of RPLC, enabling you to address routine and complex separations challenges while delivering sensitivity and throughput never before possible.


Easily add mass detection with the ACQUITY QDa™ Detector, and seamlessly integrate mass spectral information into your same workflow. www.waters.com/upc2


28478pr@reply-direct.com ACQUITY UPLC® I-Class System The details always matter.


The ACQUITY UPLC I-Class System is designed specifically for the rapid pace of laboratories on the cutting edge of research, and provides the most powerful solution to the most critical need in separation science today – successfully analysing compounds that are limited in amount or availability amid a complex matrix – more rapidly than ever before. Developed to produce the most accurate and reproducible separations, you will get the most information possible and accelerate your laboratory results.


The high pressure (18,000k psi-capable) ACQUITY UPLC I-Class System has been purposefully engineered for the lowest dispersion, and with an extended pressure/flow envelope, complex separations can be accelerated without compromising chromatographic fidelity. It also provides the lowest carryover, complementing MS sensitivity and extending MS linear dynamic range.


Whether your work involves therapeutics or combinations of medicines and dosing levels, as in high potency medications or biotherapeutics, or your lab focuses on areas in trace analyses such as food safety, the ACQUITY UPLC I-Class System will enable you to solve your most complex challenges.


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ACQUITY UPLC H-Class System Method development and method transfer made easy.


With the ACQUITY UPLC H-Class System, your laboratory can achieve true UPLC separations without changing the way you work with your current quaternary-based LC system. The system is streamlined to bring together the flexibility and simplicity of quaternary solvent blending and a flow-through-needle injector to deliver the advanced performance expected of UPLC separations – high resolution, sensitivity and improved throughput – while maintaining the robustness and reliability that ACQUITY UPLC systems are known for.


Choosing the ACQUITY UPLC H-Class System enables you to continue running existing HPLC methods on a forward-looking LC platform, allowing you to confidently and seamlessly transition to UPLC separations - when you’re ready - using integrated system tools and reliable column kits for method transfer and method development that simplify migration. And, when paired with the ACQUITY QDa Detector, you can combine qualitative and quantitative data into the same workflow with complementary optical and mass detection.


www.waters.com/hclass 28474pr@reply-direct.com ACQUITY UPLC M-Class System Let your LC inlet do the work for your nano- to microscale separations.


The ACQUITY UPLC M-Class System is the system of choice for the highest quality nano- to microscale UPLC separations, for every laboratory performing sample-limited LC/MS analyses. With unprecedented usability in a nano- to microscale platform, the ACQUITY UPLC M-Class System enables laboratories to succeed in analysing compounds that are severely limited in amount or availability, even amid a complex matrix over several orders of magnitude.


Confidently achieve your laboratory goals with high-efficiency, 15,000 psi-capable ACQUITY UPLC M-Class Columns ranging from 75 µm to 1.0 mm I.D. by using complementary mass spectrometry to support our full range of column I.D.’s, or run 300 µm to 1.00 mm I.D. columns with optical detection.


The system also offers a range of flexible configurations for HDX technology, and 2D analysis, and UV detection. www.waters.com/mclass


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Prep 100q SFC System A greener alternative to high-throughput purification.


The Waters Prep 100q SFC System provides high-throughput, semi-preparative to preparative scale purification, meeting the increased demand for higher productivity, greater flexibility, and lower costs per sample.


Leveraging the benefits of green purification technology, the Prep 100q SFC System utilises CO2 laboratories overwhelmed with solvent disposal and time-consuming sample dry-down.


as the primary mobile phase, which is a beneficial alternative for


The only open-bed preparative scale SFC system on the market today, the Prep 100q SFC System is the ideal platform for a wide variety of purification applications: chiral and achiral separations, impurity isolation, natural products, and purification of standards and libraries of drug-like compounds.


With the addition of the ACQUITY QDa Detector, the benefits of mass-directed SFC purification have just become more attainable. While retaining the high specificity and sensitivity essential to MS directed purification, its intuitive user interface and small footprint make the ACQUITY QDa Detector a natural fit for Prep 100q SFC MS System.


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INTERNATIONAL LABMATE - JANUARY/FEBRUARY 2014 - ADVERTORIAL


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