Chromatography 11 New Data Demonstrate Monoclonal Antibody Characterisation Using Versatile SEC-MALS Instrument
Malvern Instruments has posted a new application note demonstrating the use of the company’s Viscotek SEC-MALS 20 multi angle light scattering (MALS) detector for size exclusion chromatography (SEC) in the analysis of monoclonal antibodies. The application note, ‘Molecular weight measurements of an antibody using Viscotek SEC-MALS 20’, reports experimental data for the analysis of aggregates within monoclonal antibody formulations and can be freely downloaded at
www.malvern.com/secmalslaunch
Monoclonal antibodies are being targeted for use in a growing range of therapeutic applications. Measuring the molecular weight of the protein, monomer, oligomers and aggregates within the sample and in formulations is an important part of assessing their safety and efficacy as drugs. Light scattering techniques allow the measurement of absolute molecular weight without relying on potentially inaccurate calibration methods, with MALS an established technology within the industry.
When added to a GPC/SEC chromatography system, the new Viscotek SEC-MALS 20 delivers market-leading MALS detector performance with high accuracy, even at high molecular weights. Its launch makes the Malvern Instruments Viscotek light scattering detector range the broadest available, allowing the company to offer unbiased, optimised solutions for any GPC/SEC application.
27869pr@reply-direct.com Ultra-inert Solid-core UHPLC/HPLC Columns with Extended pH Stability
ACE UltraCore is a new range of ultra-inert solid-core (superficially porous) particle UHPLC/HPLC columns from Advanced Chromatography Technologies Ltd. The monodisperse particle distribution of these phases combines high efficiency and performance, with a low column back pressure, to deliver exceptional chromatography.
ACE UltraCore is available with SuperC18 and SuperPhenylHexyl bonding. Both phases feature proprietary Encapsulated Bonding Technology (EBT), which results in excellent peak shape and superb phase stability across an extended pH range of 1.5 to 11.0. Encapsulated Bonding Technology dramatically increases the ligand coverage of the silica surface and effectively eliminates the effect of unbonded silanol groups on separations. This higher ligand coverage results in improved inertness, chromatographic performance and stability. With these exciting new solid-core phases chromatographers can confidently exploit selectivity at low, intermediate and high pH for rapid, systematic method development.
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ADVERTORIAL
Ellutia Offer Gas Chromatography University Discounts
Ellutia ltd is offering special educational discounts on their range of gas chromatography instruments for universities for use in both teaching and research projects.
Ellutia are able to offer a range of gas chromatography systems
suitable for teaching modern gas chromatography techniques. The 200 Series GC is a compact bench top gas chromatograph, which was designed with education in mind. Its features include a split/split-less injector, electronic programmable pressure control, a programmable temperature controlled oven, capillary and packed column capability and a choice of detectors (FID, TCD, ECD & FPD). Its compact size means unlike many other GC’s when the teaching is finished it can be disconnected and stored until it is next required rather than taking up valuable bench space.
Ellutia also works closely with universities on research projects to deliver cost effective customised chromatography systems designed to fit specific research applications. Examples of systems already in use by universities for research purposes include;
• Semi Portable Systems for in-field analysis • Air monitoring systems • Food and Beverage research • Online monitoring systems
If you require further information on the Ellutia range of instruments for education or would be interested in a free trial of a system please contact Ellutia at
info@ellutia.com or visit the website at
http://www.ellutia.com
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Analysis of Nitrosamines in Children’s Toys
Nitrosamines are highly toxic compounds that can enter the body through ingestion or skin adsorption. It is now required that levels N-nitrosamines and N-nitrosable substances in certain types of toys are accurately monitored as many cancers
have been attributed to the exposure of nitrosamines or nitrosamine forming compounds. The new chemical requirements for toys under the EU Safety Directive 2009/48/EC came into force on the 20th July 2013
The Ellutia 800 Series Thermal Energy Analyser is one of the detectors specified as suitable for use in the EN 71-12:2013 Safety of toys N-Nitrosamines and N-nitrosatable substances directive.
The 800 Series Thermal Energy Analyser (TEA) has been an industry standard for nitrosamine analysis since its introduction thanks to its simple operation, low limits of detection, almost infinite selectivity for nitrogen containing compounds, and considerably lower cost than expensive HPLC- MS/MS or GC-MS/MS systems. The 800 Series TEA can be interfaced with most common GCs.
Chromatography Solutions
For further information visit
http://www.ellutia.com/
800TEA.html
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Tel: +44 (0)1353 669916
Fax: +44 (0)1353 669917 Web:
www.ellutia.com Email:
info@ellutia.com
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