18 Report on the use of Benchtop NMR System at the Rochester Institute of Technology
Dr Joseph Hornak is Professor of Chemistry and Imaging Science at the Rochester Institute of Technology, RIT, where he teaches courses in magnetic resonance imaging, nuclear magnetic resonance spectroscopy, analytical chemistry, and physical chemistry. He is also Director of the Magnetic Resonance Laboratory, MRL, a research and development laboratory on the RIT campus. Dr Hornak is author of more than 170 published and conference papers on magnetic resonance related topics.
MRL is a research and development laboratory devoted to solving real world problems using magnetic resonance. Currently the lab is working on a phantom for fMRI, developing applications for low frequency electron paramagnetic resonance, and measuring relaxivities of some targeted MRI contrast agents. Dr Hornak’s student, Amy Becker, a 2nd year Imaging Science student at RIT, is working on the analysis end of the project in volving the contrast agents. The project is a collaboration with a research group headed by Dr Hans Schmitthenner which is synthesising some unique, targeted MRI contrast agents. Amy’s project is to measure the NMR relaxivity of the agents. As with all contrast agents, you want to know the relaxivity at the field strength they will be used. Most clinical MRI systems in the world operate at a field strength of between ~0.75 and 3.0 Tesla. MRL chose the Magritek Spinsolve system because it operates at ~1 Tesla and is therefore a perfect instrument for getting these values at the low end of this range.
Speaking of the selection of the Magritek system, Dr Hornak said “We chose the Spinsolve NMR for use in an Instrumental Analysis laboratory with 90 students. In addition to NMR, students get exposure to UV-Vis, fluorescence, AA, and IR spectroscopies. We wanted an NMR with a low operating cost which could be sited in the lab, and leave the students with a positive NMR experience. Just like with the Terranova from Magritek, the Spinsolve scores high points for ease of use, both in collecting and processing the data. Shimming is easy and does not need to be performed on each sample. The resolution is sufficient for students to easily analyse 1- and 2-D H spectra of small molecules. It can be used to measure spin- lattice and spin-spin relaxation times at 40 MHz that we cannot take with other instruments.”
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Isotope Ratio Measurement Can Now go to the Sample Site
Raster Orbital Scanning Technology Recognised at TASIA Awards
The Raster Orbital Scanning (ROS) feature of the IDRaman family of products from Ocean Optics has been recognised as one of 2013’s 15 best innovation technologies by The Analytical Scientist magazine, an industry publication. ROS is a novel Raman spectroscopy sampling technique that helps to derive more accurate and comprehensive measurement results. The IDRaman mini handheld Raman spectrometer and the IDRaman reader integrated Raman spectrometer both feature ROS.
ROS increases the sensitivity of Raman measurements up to 10 fold by rastering a tightly focused laser beam over a larger area, encountering more Raman-active compounds. The reduction of the background by ROS provides a more accurate result and is especially ideal for applications like surface enhanced Raman spectroscopy (SERS). Rastering a tightly focused beam allows the resolution of measurement to be mainlined, ensuring accuracy for applications that rely on library matching.
ROS offers the advantage of allowing higher laser powers to be used for measurement without damage to the sample. This supports the development of low-cost Raman detection in mainstream applications such as anti-counterfeit and medical diagnostics. By scanning a larger area with a the laser beam, The Analytical Scientist points out that conventional paper could be used as a SERS substrate for a point-of-care diagnostic tests, as opposed to pristine surfaces.
Thermo Fisher Scientific have introduced the Thermo Scientific Delta Ray Isotope Ratio Infrared Spectrometer.
The Delta Ray system is a new category of analyser for the continuous measurement of isotope ratio values from CO2 in ambient air. The ability to transport the system into the field can enable scientists to continuously collect data, 24 hours per day, seven days per week. Scientists can measure short duration phenomena that may have previously been missed due to the low-frequency sample acquisition.
“A step forward in the surveillance of volcanoes is now possible,” said Andrea Rizzo, researcher studying Mt Etna for Istituto Nazionale di Geofisica e Vulcanologia, (INGV), Sezione di Palermo, Italy. INGV-Palermo performs geochemical monitoring of Mt Etna to evaluate volcanic activity with the goal of predicting eruptions.
INGV-Palermo evaluated a prototype Delta Ray system in July and again in September, 2013 at Mt Etna, from sea level to just under 9,900 ft up the mountain. CO2 isotope data was captured from the atmosphere, fumaroles and crater plume. The instrument stood up to the rigors of this harsh environment, and INGV-Palermo research group is now planning a long-term study in which the instrument will operate unattended on Mt Etna for a number of months.
The Delta Ray analyser uses laser-based mid-infrared spectroscopy to simultaneously measure carbon13 isotope and oxygen 18 isotope with a precision of better than 0.1 parts per thousand in minutes. The mid-infrared range produces absorption signals about 8,000 times stronger than the near-infrared for superior performance and reduced need to clean the mirrors. The system’s Universal Reference Interface is engineered to automate referencing and calibration for verifiable measurements and high-confidence results. The system is designed to measure large and small- scale changes in atmospheric CO2 at concentrations from 200 ppm to 100%
In addition to transportability, the instrument is designed to be robust and simple to operate. Thermo Scientific Qtegra software is easy to navigate and enhances usability.
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“This unique sampling technique helps make Raman measurements more accurate and reliable, enabling our customers to do more,” said Richard Pollard, President of Ocean Optics. “We are excited to hear that Raster Orbital Scanning has received this award.
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FDA Compliant Spectrophotometer Software The FDA conforming WinASPECT®
PLUS software for the SPECORD®
PLUS series of
Analytik Jena offers the ideal tool needed for efficient analysis in all fields, from R&D to production, from quality control to lab routine. Industries like pharmacy, biotechnology and medicine are subject to strict requirements of regulatory authorities. The Food and Drug Administration (FDA) is the supreme authority for consumer protection of the USA. They establish the requirements for recording and electronical signatures of data, which are defined in the 21 CFR (Code of Federal Regulations) Part 11.
With regard to verifiability, forgery protection and traceability the WinASPECT® PLUS FDA
21 CFR Part 11 software offers a comprehensive user management to comply with all requirements of FDA conforming analysis, e.g. individual access rights for different users, electronic signatures, passwords with limited period of validity and an Audit Trail. This guarantees absolute data security.
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A New App for Mass Spectrometry
The new Hiden Analytical Overlap Evaluator for Android & iPad is a reference tool for users of mass spectrometers operating in the fields of vacuum science and vacuum processing, and for advanced researchers using real time gas analysis systems. The evaluator enables the user to create a mass spectral overview of multiple fragmentation spectra to identify the mass peaks with least spectral interference and therefore most suited to species monitoring, and includes a quick mass peak look up table from a library of common gas and vapour species.
The MS spectral overlap evaluator for Android is available free from the Google Play Store
http://tinyurl.com/HidenMSEvaluatorAndroidApp.
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INTERNATIONAL LABMATE - JANUARY/FEBRUARY 2014
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