Chromatography 13 Trace Level Quantitation of Multiple Compounds
Shimadzu’s LCMS-8050 triple quadrupole LC-MS/MS meets the growing demand for trace-level quantitation in clinical research and other markets. It incorporates proprietary ultrafast technologies as well as a newly developed ion source and collision cell technology. As the flagship model of Shimadzu’s UFMS (Ultra-Fast Mass Spectrometry) product line, the LCMS-8050 features high sensitivity, high data quality and the world’s fastest data acquisition rates.
Delivering attogram-level (10-18 grams) sensitivity and possessing unsurpassed ruggedness, the LCMS-8050 achieves its improved sensitivity through two important technologies: newly designed Heated ESI source improves desolvation and enhances ionisation efficiency with the addition of a heated gas used in combination with the nebuliser gas; UFsweeper® optimising the collision cell pressure.
III collision cell enhances CID efficiency by
The newly engineered high voltage power supply enables a maximum scan rate of 30,000 u/sec and a 5 msec polarity switching time, making the LCMS-8050 combined with Nexera UHPLC the ideal platform for laboratory productivity. It is now possible to include 1,000 events with up to 32 channels per event for a maximum of 32,000 MRMs per analysis.
The instrument features user-friendly operation and is easy to maintain. The plug-in for the new ion source enables easy changing from ESI to APCI or to dual ionisation mode (DUIS). LabSolutions LCMS Version 5.60 software provides seamless integration of HPLC and MS control. An automated MRM optimisation routine allows unattended optimisation of multiple compounds.
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New QDa Detector Brings Push-Button Mass Detection to Chromatography Waters Corporation introduces the new Waters®
), Alliance®
new mass detector worldwide. Designed as a synergistic component of a chromatographic system, the ACQUITY QDa Detector is compatible with Waters ACQUITY® UltraPerformance Convergence Chromatography™ (UPC2®
ACQUITY QDa™ Detector, the first mass detector to bring high-quality, mass spectral data to chromatographic separations. Waters is now shipping the UltraPerformance LC®
(UPLC®
), ACQUITY high performance liquid chromatography (HPLC) and Waters supercritical fluid chromatography (SFC) and LC-based purification systems.
The ACQUITY QDa Detector addresses the barriers of complexity, size and cost that have hindered the adoption of mass spectrometry for everyday use. It is purposefully designed for analytical scientists who need mass spectral data without the complexity of a mass spectrometer. With the on/off simplicity that analytical scientists have long wanted from mass spectrometry, the ACQUITY QDa Detector fully automates sample analysis and eliminates sample-specific adjustments for certainty in sample results, from user to user and system to system. Robust and reliable enough for routine use, the ACQUITY QDa Detector generates the high quality mass spectral data expected of a single quadrupole mass spectrometer in a mass detector no bigger than a familiar photodiode array (PDA) detector.
The ACQUITY QDa Detector complements optical detection, such as the PDA detector, by confirming the identity of compounds with mass spectral information. Additionally, the ACQUITY QDa Detector extends the limits of sample detection for a chromatographic separation by quantifying compounds having no UV response or that are present at levels not detectable and quantifiable by optical detection. By simplifying laboratory workflows, the detector enhances the value of every analysis and increases productivity by eliminating the need to run additional assays or turn to time-consuming alternative techniques in order to establish with certainty the levels and identity of specific sample compounds. The ACQUITY QDa Detector is available now for separations systems running Empower®
2 & 3 Chromatography Data
System (CDS) software, including enterprise deployment with automated qualification. Empower 3 makes mass and UV spectral data processing as integrated as the separations systems they were acquired on. The ACQUITY QDa Detector is also available now for MassLynx®
4.1 Mass Spectrometry Software.
28415pr@reply-direct.com ADVERTORIAL F-DGSi High Purity Hydrogen Generator
The F-DGSi ALLIANCE H2 generator saves space and eliminates the risks associated with storing high pressure cylinders, but also the hidden costs associated with piping connections, manometers, ordering, renting and delivering, servicing and maintaining cylinders.
F-DGSi offers 4 ranges of laboratory hydrogen gas generators: • LC-H2 99,9995% • ND-H2 99,9995% • PAR-H2 99,9999% • WM-H2 99,99999%
Common Features and Benefits • multistage fail-safe system • automatic H2 leak detection • class leading cell: reliable and robust • unique water quality management system • auto water fill included
• continuous monitoring of vital parameters • PC monitoring and control included • stackable with zero air generator to form an innovative modular FID gas station
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