MICROSCOPY 81


live cell morphological features without interfering with the cell’s biological functions. It is also becoming very important in other types of cell-related research that involve fluorescence in situ hybridisation (FISH).


Te latest from Shimadzu, the iMScope TRIO, is an advanced imaging technology platform that brings together mass spectrometry and high resolution morphological images.


Te company says it is the world’s first imaging technology that supports high resolution morphological imaging from an optical microscope overlaid with molecular distribution images generated by high mass accuracy mass spectrometry with a spatial resolution of 5µm.


“Te accurate and high resolution images from the iMScope TRIO will drive research in a broad range of biological and clinical


applications including disease-specific markers based on differences in molecular distribution in normal and diseased tissues and pharmaceutical drug distribution, metabolism and toxicology,” says Shimadzu.


In terms of features, the system is equipped with an ultraviolet laser that can be narrowed to a minimum 5 µm beam diameter and its mass spectrometry imaging achieves a spatial resolution of 5 µm. Te system elucidates the layered structure of lipids contained in tissues as little as 10 µm thick. Optical images obtained with a high resolution optical microscope and mass spectrometry images can be overlaid using a dedicated software application enabling information rich data analysis.


High mass accuracy mass spectrometry data is generated by the ion-trap TOF (time- of-flight) MS. According to


Shimadzu this technology delivers an unparalleled degree of information for molecular identification using mass spectroscopic analysis. Te design not only also supports high resolution spatial imaging, but also can be used as separate interface to LC for high mass accuracy LC/MS/MS analysis.


Finally, Zeiss is to provide imaging tools such as its Elyra technology (Fig. 2) for use in the US National Institutes of Health (NIH) Brain initiative as part of a US$12 million (€9.5 million) public-private collaboration with UC Berkeley to support its Brain Microscopy Innovation Centre (BrainMIC). Te US Brain initiative is focused on advancing tool development in neuroscience including microscopy and advanced imaging technologies. As a result of this collaboration, the Brain MIC will be able to fast-track microscopy development for emerging neurotechnologies.


“Shimadzu’s iMScope TRIO, is an advanced imaging technology platform that brings together mass spectrometry and high resolution morphological images.”


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