48 DRUG DISCOVERY & DEVELOPMENT
“Cell-based assay use is rapidly increasing in pharma and academic research. The cell based assay global market is expected to grow US $ 1.5billion (€1.1 million) by 2017.”
manual modes to monitor levels of premixed gases.
Superior cell growth is only possible in a sterile environment with constant atmospheric conditions. Te advantage of incubating and measuring in one combination device is the driving force behind new techniques in multiwell assays.
Tere are many contaminants in labs, and having samples incubating and measured in the same microplate reader minimises the exposure to atmospheric impurities. Tis feature can also help avoid excessive movement of plates and accidental errors. In addition, throughout the cell assay process, exact monitoring of growth curves with no gaps in data can be optimised with a combination system.
EUROLAB DEC 2014.pdf 1 06/11/2014
Once the growth process is optimised, detecting metabolic changes with multimode and absorbance readers in the same
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instrument helps streamline the research process.
Tere are many cell-based applications that utilise microplate readers. Tis widely used instrument enables multiple samples to be measured in long-term proliferation and induction studies, growth monitoring of multiple different microorganisms and high throughput screening of proteins in cells. For example, when using a Nunc plate that minimises evaporation, data can be collected in the same instrument, and cells can incubate for long term studies. Another important application used in microplate readers is measuring proteins in carcinoma cells after hypoxia induction.
An application for growth monitoring of bacteria, such as
the study where Helicobacter pylori O2
measured for 28 hours is now possible with new technology.
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Multimode microplate readers are rich with innovative features designed for the most widely used applications for 96 and 384-well plates. Whether detecting reporter genes, proteins in cell signalling, or metabolic processes, these instruments now have user-friendly platforms and optical features with excellent levels of sensitivity for fluorescence or luminescence- based assays to support research centres.
A clear understanding of the challenges in cell-based assays and instrumentation features designed to control common problems will help researchers identify prime target candidates.
Sarah Verna is Product Manager – Cell Culture, Thermo Fisher Scientific.
www.thermofisher.com
secure, hygienic and simple C M Y CM MY CY CMY K
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info@melaphone.co.uk www.melaphone.co.uk
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Clean rooms Hospitals Cash Desks Prisons
Pharmacies Reception Areas
Food areas Cinemas
Or any area where safe communication is required For more information ✔ at
www.scientistlive.com/eurolab
Melaphone speech panels are specifically designed to allow sterile communication with a high degree of vision and safety. There is no thru-air flow, therefore, no transmission of germs, contaminants, draughts or dust. Speech is transmitted through a transparent diaphragm which also gives protection against noxious sprays. The system is non-electrical nor battery powered so requires the minimum maintenance through its installation life.
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