50 DRUG DISCOVERY AND DEVELOPMENT
“Reasons for cross contamination can be many. Insufficient cleaning of equipment is one of the most obvious and easiest to rectify.”
Fig.3. Anmasi’s SilentSonic ultrasonic cleaning solution.
conversation. Tis reduction in noise, compared to standard ultrasonic units, is obtained through an innovative design and the use of a special insulation, PureSound. Tis significantly quieter unit makes the work environment more comfortable for personnel.
Fixtures – the key to success Most standard ultrasonic cleaning units utilise a simple wire basket to hold the items to be cleaned while submerged in the chamber. Tis approach will work with many solid-shaped items, but if more complex equipment is to be cleaned, a specially designed
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fixture is needed. Te fixture will guarantee that the equipment is always oriented in the most optimal position and ensure that every cleaning job is performed with identical conditions – thus making the validation process easier.
A prime example of this is the cleaning of tablet tooling for micro tablets (tablets <3mm.) Tese tools are often manufactured in a multiple tip configuration, with up to 50 fragile individual tips. Add to that the tip holders, key slots and rotating heads, and you are faced with a very time-consuming cleaning job. Te alternative to
taking the whole punch apart, is simply to place it in a dedicated fixture and submerge it in the Silent Sonic ultrasonic cleaner. Tis saves considerable time while providing a thorough cleaning.
As a tablet-tooling supplier, Natoli recommends ultrasonic cleaning, since this is the most effective and gentle method. Te Silent Sonic unit’s smart design has provided new opportunities for successfully minimising cross-contamination risk. Tis innovation in standard procedure is just one way to meet EU requirements.
For more information ✔ at
www.scientistlive.com/eurolab
Nick Kristiansen is technical director of Natoli Scandinavia.
www.natoli.dk
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