52 DRUG DISCOVERY AND DEVELOPMENT
In-line tablet weight measuring provides the highest possible precision and continuity of the tablet weight even when there are variations in the bulk density.
It minimises the product losses, which is especially important when expensive ingredients are processed. Instead of a statistical process control, the CWC provides a continuous monitoring and therefore a higher level of certainty. No operator is necessary for the weighing process, which means that potential user errors are minimised.
It is possible to check up to one tablet per each turret revolution, with an accuracy of 0.1mg.
With the traditional ‘20 tablets every 20 minutes’ set-up, if the tablet press runs with a production speed of 200,000 tablets per hour and the batch size is one million, 300 tablets are sampled. Tis means that 0.03%
Fig. 2. The CWC system can test around 74 times more tablets than traditional solutions.
of the batch is being checked. During the 20 minutes it takes to conduct the conventional weight test, the operator gets no information on the current tablet weight development.
Weight control with CWC means that during the same batch 22,000 tablets are checked, which is about 2.22% of the whole batch. Tis is about 74 times more than the traditional sampling sequence.
Due to the higher sampling rate, the reaction time of the process control is significantly reduced compared to the traditional approach and the process security is also increased.
Its makers hope that this new system could replace the traditional off-line tablet sampling for weight control in the near future.
For more information ✔ at
www.scientistlive.com/eurolab
Jutta Hartmann is with Romaco Killian in Germany.
www.romaco.com
kd-pharma.com For more information ✔ at
www.scientistlive.com/eurolab
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