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56 CHROMATOGRAPHY


separation method for the most complex sample matrices.


According to the company, the system provides a new level of knowledge and understanding of sample analytes, which is beneficial to scientists analysing pharmaceutical impurities, proteins, lipids, peptides, food extracts, and natural products.


Comprehensive 2D-LC combines two independent separation modes orthogonally in combination with a dual-loop/ dual-valve alternate switching system to increase separation efficiency. Te combination of different modes enables the separation of peaks that are difficult to separate using conventional LC. In addition, says the company, the system achieves the highest possible theoretical plates for LC separation.


Because ultra-high-speed analysis of comprehensive 2D-LC requires quick data sampling, the Nexera-e incorporates the Nexera X2 photo-diode array detector, SPD-M30A, which features high sampling rates up to 200 Hz.


Te Nexera-e may also be used with the LCMS-8050 triple quadrupole LC-MS/MS. Tis features ultra-high-speed data scanning using ultra-fast mass spectrometry (UFMS) technologies. Combining the


Fig. 2. Vanquish’s monolithic case stands about 25% lower than comparable UHPLC modular stacks.


two provides an additional orthogonal dimension to this powerful chromatography separation technology.


LCxLC-Assist Software is used for configuration settings as it provides easy set-up of all the 2D-LC instrument parameters. Acquired data is converted to 2D contour plotting using ChromSquare, which is dedicated software for 2D-LC analysis. A peak on the chromatogram is recognised as a spot or feature on the contour plot. In addition, ChromSquare software displays an MS spectrum in real time, and is able to calculate a standard curve for quantitative analysis based on the contour spot.


For its part, Termo Fisher Scientific has designed its new Vanquish ultra high performance liquid chromatography (UHPLC) system from the ground up in order to provide new levels of performance, productivity and usability when used as both a standalone system or with the latest mass spectrometers.


One big difference from standard UHPLC systems is Vanquish’s monolithic case. Rugged and flexible, the system stands about


25% lower than comparable modular stacks. It is also rugged, flexible and easy to service (Fig. 2).


At the heart of the Vanquish concept is the new family of Termo Scientific Accucore Vanquish UHPLC columns.


Agilent/Shimadzu tie-up improves lab choice A


gilent Technologies and Shimadzu have released gas chromatography (GC) instrument control for their respective


chromatography data systems (CDS). The move provides customers in analytical laboratories with more freedom of choice when selecting a chromatography data system. Agilent has released drivers for Shimadzu GC-2010, GC-2010 Plus and GC-2014 integrating to Agilent’s OpenLAB CDS, and Shimadzu has released drivers to control Agilent 6890, 6850, 7820 and 7890 GC instruments in Shimadzu’s LabSolutions. These releases are the result of the joint collaboration – employing


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RapidControl (RC.NET) instrument drivers – announced in May 2013 to preserve customers’ investments in workflows and operating procedures. This is the latest move in a number of recent


collaborations between the two companies. For example, since mid-2013 Agilent’s OpenLAB CDS has supported Shimadzu’s Nexera and Prominence HPLC lines and Shimadzu’s LabSolutions CDS has supported Agilent’s 1100, 1200, 1260 and 1290 series instruments. “Agilent continues to follow an open systems


approach for the laboratory to deliver value to our customers,” said Bruce von Herrmann, vice president and general manager of Agilent’s software and informatics


business. “To reduce costs and enhance the customer experience, we are working with other manufacturers like Shimadzu to enable full and reliable control of lab instrumentation from any CDS. These new releases demonstrate that Rapid Control is the predominant industry standard for analytical instrument control.” Masahito Ueda, Shimadzu general manager of the GC business unit in the analytical and measuring instruments division, also welcomed the tie-up: “The adoption and support of RC.NET drivers provide a more integrated solution to customers who require a single CDS product to support seamless multi-vendor control of all instruments in their laboratory.”


Tese have been specially designed to optimise performance. Tey feature 1.5 µm solid core particles utilising core enhanced technology to take full advantage of the Vanquish system’s 1500 bar (22,000 psi) maximum pump


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