BIOTECHNOLOGY 103
Solving aseptic challenges in the biotech industry The QMI Safe Septum has been
After supporting the dairy and food and beverage industries for more than 30 years, an aseptic fluid handling system has found new applications in the growing biotechnology industry. Researchers in the industry have
been perplexed by questions on how to aseptically collect a sample from a bioreactor and/or holding vessel and how they could aseptically inoculate a culture into their bioreactors. The QMI system has provided a
solution to both problems.
now been used successfully to control contamination of bioreactors. A major challenge in the industry
is keeping contaminant organisms out of a bioreactor, especially during long production runs. QMI’s system is able to maintain the
aseptic integrity of bioreactors where conventional flap septa cannot. The conventional flap septa cannot maintain an aseptic seal, thus compromising the aseptic integrity of the bioreactor. Due to its three-part
construction, the device is aseptic, pressure and temperature stable, and pre-sterilised. The multi-port designs
are quickly retrofitted into a user’s existing bioreactor and it is therefore very easy for the researcher to use. The system has individual needle guides that ensures that all needle insertions are completely separate and
physically isolated from one another. Since the needle guides are
covered by a thin membrane layer, researchers will always know what needle guides have been used. The system has been tested
under extremely contaminated conditions and has been proven to automatically reseal puncture holes, eliminate leakage and physically exclude bacteria from the sampling site. QMI has conducted studies using an
independent testing laboratory that have demonstrated the system did not fail or show signs of leakage with sustained pressures of 150psi at temperatures of 250o
C for a period of 200 hours even
when the ports were penetrated using an 18 gauge needle. The QMI Safe Septum has been used
to aseptically transfer materials such as acid/base for pH control, antifoaming agents, nutrient solutions, chemical
solutions used for biotransformation’s and gases. Cultured inoculums are commonly
aseptically transferred using the system and when using a peristaltic pump you can control the rate for which the inoculums are introduced into the bioreactor.
For more information ✔ at
www.scientistlive.com/eurolab
QMI is based in Minnesota, USA.
www.qmisystems.com
Your Next NGS Partner
• • • •
RNA sequencing – from microRNA to the whole transcriptome
A complete sample-to-answer solution
Personalized scientific consultation and support
Fast turnaround times and first class reports
Find out more
exiqon.com/ngs-services
For more information ✔ at
www.scientistlive.com/eurolab
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88 |
Page 89 |
Page 90 |
Page 91 |
Page 92 |
Page 93 |
Page 94 |
Page 95 |
Page 96 |
Page 97 |
Page 98 |
Page 99 |
Page 100 |
Page 101 |
Page 102 |
Page 103 |
Page 104 |
Page 105 |
Page 106 |
Page 107 |
Page 108 |
Page 109 |
Page 110 |
Page 111 |
Page 112 |
Page 113 |
Page 114 |
Page 115 |
Page 116 |
Page 117 |
Page 118 |
Page 119 |
Page 120