SPECTROSCOPY 67
On the move with portable spectrometers
Sean Ottewell reports on the power, performance and flexibility of portable spectrometers and outlines many benefits they offer.
Sean Ottewell nous rend compte de la puissance, de la performance et de la flexibilité des spectromètres portables et résume leurs nombreux avantages.
Sean Ottewell berichtet über die Leistungsfähigkeit, Performance und Flexibilität tragbarer Spektrometer und fasst ihre vielen Vorteile zusammen.
T
Fig. 1. Alongside technology improvements is a new service and support organisation aimed at helping both new and existing users.
he successful installation of the world’s first 21 Tesla (T) magnet for
Fourier transform ion cyclotron resonance (FT-ICR) has been announced by Bruker and the US National High Magnetic Field Laboratory (NHMFL) at Florida State University (FSU).
According to Bruker, the installation represents the world’s highest field, persistent, superconducting magnet suitable for FT-ICR mass spectrometry (FTMS).
Te 21T magnet was designed and built by Bruker in
collaboration with NHMFL scientists, and will be used in the NHMFL FT-ICR programme in a project funded by the US National Science Foundation that will make cutting edge FT- ICR technologies available to the larger community of scientists.
FT-ICR is the highest resolution mass spectrometry technique available, and is useful in the analysis of extremely complex mixtures, including applications in dissolved organic matter (DOM), metabolomics, top-down proteomics, and matrix-assisted laser desorption ionisation imaging (MALDI).
As the performance of FT-ICR systems improves with increasing magnetic field, the 21T magnet is expected to enable further dramatic improvements in mass resolution, mass accuracy and dynamic range compared to the previous highest field of 15T.
Professor Alan Marshall, the Robert O Lawton professor of chemistry and biochemistry at FSU and director of the High Field FT-ICR programme at the NHMFL, pointed to three primary drivers for the new instrument.
First is faster throughput without loss of mass resolution for top-down proteomics. Second is an extension of the size and complexity of protein complexes whose contact surfaces are mapped by solution-phase hydrogen/deuterium exchange.
Lastly is improved mass resolution and dynamic range for characterising compositionally complex organic mixtures.
He adds that the higher magnetic field should result in dramatic improvement (by factors of 40- 100%) in FT-ICR MS figures of merit, including mass resolution and resolving power, mass accuracy, dynamic range, and data acquisition speed.
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