54 LIFESTYLE COSMETICS A I feel HAPPY,
FANTASTIC with MORE QUALITY OF LIFE
58% I feel SATISFIED 63% 58% x 1.6 37% 29% 29% 26% 17% x 2.2 39% 63% x 3.9 I feel ENTHUSIASTIC 67% B I feel HAPPY,
FANTASTIC with MORE QUALITY OF LIFE
I feel SATISFIED I feel ENTHUSIASTIC 67%
Figure 7: Percentage of volunteers choosing the maximum positive score for each question. (A) Conscious and subconscious responses in volunteers treated with monk fruit active. (B) Subconscious responses differences between placebo and active treatment.
active feel enthusiastic, 63% more satisfied and 58% feel fantastic at a subconscious level (Fig 7B), the one responsible for decision making. When we analysed the impact of using our
active on the volunteer’s lives, the most relevant feeling was happiness (Fig 8). Surprisingly, health and wellbeing were also top responses together with a noticeable reduction in wrinkles. Notably, the impact on positive emotions is always superior to placebo for volunteers using our Monk fruit active. In summary, mature women treated with
2% Monk fruit active not only look good but feel fantastic increasing their self-esteem and wellbeing.
Conclusion During the study of this ingredient, several novel miRNAs were described in dermal fibroblasts, suggesting a possible role of their expression in regulating components of the extracellular matrix. Momordica grosvenorii fruit active rebalances the gene expression in aged dermal fibroblasts through regulation of the miRNA expression, increasing the synthesis of different components of the extracellular matrix and improving fibroblast function, thus demonstrating a well-ageing role. It was also shown that the Monk
Comfortable Well being Health
10 8 6 4 2 0
Happiness
fruit active delivers significant increased hydration and luminosity to the skin, as well as densification with a clear reduction in the neck folds – all signs of a healthier and better functioning skin. Moreover, the Monk fruit active impacts differentially on the subconscious of the volunteers increasing their happiness and quality of life. In summary, our ingredient not only improves physical aspects of the mature skin but also positively impacts on the emotional wellbeing, and therefore creates a holistic experience. Because overall wellbeing is seen as
integrative beauty that embraces both the physical aspect and emotional health. Because happiness is the key to beauty.
PC
References 1. Pal S, Tyler JK. Epigenetics and aging. Science Advances 2016; 2(7): e1600584
2. Thalyana SV, Slack F J. MicroRNAs and their roles in aging. J. Cell Sci. 2012; 125: 7-17.
3. Ugalde AP, Español Y, C López-Otín. Micromanaging aging with miRNAs: New messages from the nuclear envelope. Nucleus 2011; 2:6, 549–555.
4. Mancini M, Lena A. M., Saintigny G, et al. MicroRNAs in human skin ageing. Ageing
Placebo ■ Wonderage ■ Research Reviews 2014; 17, 9–15
5. Edeleva EV, Shcherbata HR. Stress-induced ECM alteration modulates cellular microRNAs that feedback to readjust the extracellular environment and cell behavior. Frontiers in Genetics 2013; 4, 305.
6. Hawkes, J. E., Nguyen, G. H., Fujita, M., et al. microRNAs in Psoriasis. J. Invest. Dermatol. 2016; 136(2), 365–371.
7. Chou C-H, Shrestha S, Yang C-D, et al. miRTarBase update 2018: a resource for experimentally validated microRNA-target interactions. Nucleic Acids Research 2018; 46(D1), D296–D302.
8. Vlachos I S., Zagganas K, Paraskevopoulou MD. DIANA-miRPath v3.0: Deciphering microRNA function with experimental support. Nucleic Acids Research 2015; 43(W1), W460– W466.
9. Pasquali L, Xia P, Srivastava A, Pivarcsi A, Sonkoly E. miR-378a is overexpressed in psoriasis keratinocytes and potentiates IL-17A mediated inflammatory responses. J. Invest. Dermatol. 2019; 139(9S): S276.
10. Machado IF, Teodoro JS, Palmeira CM, Rolo AP. miR-378a: a new emerging microRNA in metabolism. Cell. Mol. Life Sci. 2019. https://
doi.org/10.1007/s00018-019-03375-z.
Youth
Relationship Wrinkles reduction
Figure 8: Impact on positive emotions of both treatments (subconscious responses).
PERSONAL CARE June 2021
Figure 9: Volunteer treated with Monk fruit extract and its impact on her well being.
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Conscious Subconscious
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