SUSTAINABILITY
classified into several types, each of which presents unique challenges. Superficial blemishes, such as acne scars or vascular problems, are visible on the surface of the skin and can diminish its uniformity. Brown spots, known as age or liver spots, are
caused by excessive melanin production due to factors such as UV exposure, hormonal changes or ageing. These spots appear as darker patches and affect the overall skin tone. UV spots, a specific type of brown spots, are induced by prolonged sun exposure and are often detected with specialised imaging technologies due to their location below the surface of the skin.3,4 Clinical trials using VISIA imaging technology
have shown the Aristotelia chilensis extract to be highly effective in the treatment of these facial pigmented spots. During 28 days of twice daily application, the Aristotelia chilensis extract produced significant improvements in all types of dark spots. Superficial spots were reduced by 5.5% to 8.5%, contributing to more even skin and reducing visible imperfections. Brown spots showed reductions of 3.8%
to 6.9%, with the Aristotelia chilensis extract contributing to decreased melanin production and promoting a more even skin tone. The most notable improvement was seen in UV spots, which were reduced by 10.1% to 13.3%. This substantial reduction is attributed
to the Aristotelia chilensis extract’s ability to mitigate UV-induced melanin production and reduce oxidative stress, effectively addressing deeper sun-induced discolouration.
The potential of the Aristotelia chilensis extract as a cosmetic ingredient The successful integration of the Aristotelia chilensis extract into cosmetic formulations highlights the potential of biotechnological advances to improve both the efficacy and sustainability of products. Using stem cell technology, the Aristotelia
chilensis extract offers a powerful solution that combines potent antioxidant properties with a commitment to environmentally friendly practices. This integration represents an important step in the development of effective and responsible skin care solutions. The Aristotelia chilensis extract is an
example of how biotechnological innovations can transform the sourcing and formulation of cosmetic ingredients. Its ability to reduce melanin production, promote collagen synthesis, protect against UV-induced damage and minimise various types of facial blemishes highlights its versatility and efficacy. As the cosmetics industry continues to
explore and adopt biotechnological methods, the Aristotelia chilensis extract exemplifies the potential for other plant species to offer similar benefits.
Joining forces for a more sustainable future Increasingly, the future of cosmetics is about integrating scientific innovation with environmental responsibility. Embracing innovative new technologies such as stem cell culture and exploring new plant sources will
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Figure 5: Superficial dark-spots evolution (T0 versus T28)
Figure 6: Brown dark-spots evolution (T0 versus T28)
be crucial to developing more effective and sustainable skin care solutions. The cosmetics industry is already leading this evolution, setting new standards for beauty products that prioritise both efficacy and ecological impact. By incorporating the Aristotelia chilensis
extract and similar biotechnological innovations, the industry is demonstrating its commitment to improving the quality of products while minimising their environmental impact.
This approach not only improves the efficacy
of cosmetic products, but also promotes a more sustainable and ethical industry. The integration of these technologies marks a turning point, reflecting a dedication to both consumer welfare and the preservation of natural resources.
Conclusion In conclusion, Makistem represents a significant breakthrough in the cosmetics industry, combining high-performance antioxidant benefits with a commitment to sustainability. The biotechnological cultivation of plant stem cells offers a sustainable solution for producing high quality ingredients while minimising environmental impact. As consumers increasingly prioritise
effective and environmentally friendly products, the adoption of biotechnology methods to produce high quality ingredients with minimal environmental impact is a key step forward in the cosmetics industry. The transformation of cosmetics towards
Figure 7: UV dark-spots evolution (T0 versus T28)
more scientific and advanced sustainable solutions not only responds to current trends, but also represents a proactive move towards a more responsible and innovative future in skin care. By leading the way in efficacy and
sustainability, the cosmetics industry is shaping a new era of beauty products that reflect a deep commitment to quality, environmental care and the wellbeing of our planet.
T28 T28 T28 T0 T0 T0
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References 1. Natural & Organic Beauty Market Size, Share & Trends Analysis Report By Product (Skincare, Haircare, Makeup & Color Cosmetics, Fragrance), By Consumer (Men, Women), By Distribution Channel (Online, Offline), And Segment Forecasts, 2020 - 2027. 2021. Grand View Research
2. Wang SQ, Liao AT. Photoprotection: A Review of the Current and Future Technologies. Dermatologic Clinics. 2012; 30(2), 367-385
3. Nichols JA, Katiyar SK. Skin photoprotection by natural polyphenols: anti-inflammatory, antioxidant and DNA repair mechanisms. Archives of Dermatological Research. 2010; 302(2), 71-83
4. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine. 1997; 337(20), 1419-1428
January 2025 PERSONAL CARE
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