SKIN CARE
below the eye appeared smoother, but deeper lines were also visibly improved (Figure 6B).
Improvement of the oval face shape In a second placebo-controlled clinical study, 67 Caucasian women aged between 39 and 70 years with sagging facial skin were split into two groups and used either a cream with 0.4% goji stem cell active or the corresponding placebo cream on the entire face and neck twice daily for 28 days. The facial sagging and oval face shape was
determined by measuring the size of the neck / submandibular triangle area by image analysis of pictures of the volunteers’ faces. Results showed that treatment for four weeks with 0.4% goji stem cell active significantly improved the oval face shape by 6% compared to initial conditions. The improved V-shape of the face was also
visible in the pictures of the jawline (Figure 7). This demonstrates that goji stem cell active is indeed able to reduce facial sagging and improve the oval shape of the face.
Breast lifting effect In addition, the effect of goji stem cell active on breast sagging was tested in a placebo- controlled clinical study with 44 women aged between 18 and 44 years. The women were split into two groups, with each group applying either a cream with 0.4% goji stem cell active or the corresponding placebo on the breast area twice daily for a period of 56 days. The bust distances between the nipple
and the sternum as well as the nipple and the inframammary fold were measured by 3D Breast Imaging. Treatment with goji stem cell active for 56 days led to a significant breast lifting effect compared to initial conditions. On average, the distance from the nipple
to the sternum was decreased by 0.9% whereas the distance from the nipple to the inframammary fold was increased by 1.7% (Figure 8A). In addition, the overall breast condition of the volunteers was determined
Goji stem cell active Plant exosomes from the outside Keratinocyte
Strengthens the skin barrier
A
2.0 1.0 0
-1.0 -2.0
* *p<0.05 versus initial conditions
Nipple- Sternum
Inframammary fold
Nipple- Placebo ■ 0.4% Goji stem cell active ■ *
8 6 4 2 0
B
47 Placebo ■ 0.4% Goji stem cell active ■ *
*p<0.05 versus placebo and *p<0.001 versus initial conditions
Figure 8: Breast lifting effect and improved skin elasticity after 56 days. A: The breast lifting effect is indicated by a reduced nipple-sternum distance and increased nipple-inframammary fold distance. B: Increased skin elasticity measured in the breast area
by an investigator using the Regnault ptosis classification. According to this clinical scoring system, the
application of goji stem cell active significantly improved the breast condition by 33.3% after two months. An improvement in the breast condition was measured in 54.5% of the volunteers, with the best effect in those initially classified in the Regnault ptosis score 1. This positive outcome confirms that goji
stem cell active can reduce breast sagging through a breast lifting effect. In addition to the investigation of the breast condition and lifting, treatment with goji stem cell active for two months significantly improved the skin elasticity compared to the placebo (Figure 8B), supporting the anti-gravity effect observed in this clinical study.
Conclusion The goji stem cell active contains plant stem cell-derived exosomes, which can be applied to the skin from the outside to directly act on the epidermis. By upregulating genes important
for the skin barrier function in keratinocytes, goji stem cell active can protect and rejuvenate the skin. In addition, goji stem cell active boosts the
exosomal secretion from mesenchymal stem cells inside the skin to improve communication with fibroblasts resulting in the increased production of extracellular matrix components such as collagen and elastin. Based on this dual exosome-based mechanism (Figure 9), goji stem cell active rejuvenates the skin leading to reduced sagging and thus an improved V-shaped face and lifted breasts.
References 1. Subha D et al. Plant Nano Biology. 2023; 3:100022
2. Mu N et al. Int. J. Nanomedicine. 2023; 18:4987-5009
3. Trentini M et al. Cells. 2022; 11:3950 4. Zhou X et al. J Nanobiotechnology. 2024; 22(1):276
5. Wang Q et al. Bioeng. Transl. Med. 2024; 9(4):e10646
PC
Exosomes from the outside Mesenchymal stem cell Figure 9: Dual approach of the goji stem cell extract to rejuvenate the skin
www.personalcaremagazine.com January 2025 PERSONAL CARE
Fibroblast
Promotes collagen and elastin production Improves density
Dermis
Epidermis
Change in bust distance measurements compared to initial conditions in %
Increase in skin elasticity compared to initial conditions in %
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