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Conference Review: 18th Confocal Raman Imaging Symposium


WITec’s 2022 Confocal Raman Imaging Symposium once again brought the molecular imaging community together in person. Welcoming researchers from around the world for three days of presentations, discussions, poster sessions and equipment demonstrations, 120 participants and 29 posters fi lled Ulm’s Stadthaus, and the direct, spontaneous interaction at the core of scientifi c collaboration was on full display.


WITec Marketing Director Harald Fischer set the conference in motion with a greeting and Dr Thomas Dieing gave an overview of Raman microscopy technologies and correlative variations thereof. Professor Sebastian Schluecker provided a detailed introduction to the technique itself and Professor Juergen Popp shared insight into cutting-edge Raman imaging for medical applications and biomedical research. The evening lecture focused on Ulm’s most esteemed citizen, Albert Einstein, and was delivered by Dr Nancy Hecker-Denschlag of the Albert Einstein Discovery Center Ulm.


The second day featured a diverse lineup of speakers presenting their work in the categories of: Geo and Environmental Sciences, Life Sciences and Pharmaceutics, and Advanced Imaging and Materials Analysis. During breaks and dedicated sessions, attendees browsed the entrants in the poster competition and chatted with their authors. From the ultra-modern Stadthaus, the event relocated to a 700-year-old restaurant in Ulm for dinner.


It was there that the 2022 Poster Award was presented to Johannes T. Kehren from Hochschule Koblenz in Höhr-Grenzhausen for his work: Nitride Bonded Silicon Carbide (NBSC) The Formation of Si?N? Studied by in situ Hyperspectral Raman Imaging. Together with his colleague Olaf Krause, he investigated NBSC using Raman spectroscopy to better understand this material group, which is ideal for use in the recuperator system of waste incineration plants.


On the third day the conference moved to WITec’s recently expanded headquarters for a showcase of the latest developments in Raman microscope and software technology, carried out in new demo laboratories.


There was something for just about everyone this year: microplastics, life sciences and biomedicine, astromaterials, plant cell biology, low-dimensional materials, soil science, and pharmaceutical research. These topics were accompanied by talks on advanced techniques such as correlative Raman-SEM-EDS analysis, Raman calibration standards, and cryogenic Raman imaging.


The Symposium in Ulm was a resounding success, with a record number of participants, a varied program, and a very competitive group of posters that refl ected the ever-broadening application of Raman microscopy.


(Top) Group Photo; (Lower Right) WITec Equipment Demo Group; (Lower Left) Poster Award Winner Johannes T. Kehren with WITec Co-founder and Managing Director Joachim Koenen.


Perhaps most importantly, it cultivated a sense of community and provided a forum for the discussion of the fi eld’s most recent discoveries.


WITec look forward to continuing this tradition next year at the 19th Confocal Raman Imaging Symposium: 25-27 September 2023.


More information online: ilmt.co/PL/5ljP 58947pr@reply-direct.com


New Cryo-TEM to Help Accelerate Drug Discovery Research well as research for cancer and gene mutations.


The Glacios 2 Cryo-TEM includes automation features designed to extend accessibility to a range of cryo-EM techniques, including single particle analysis, cryo-electron tomography (cryo-ET) and microcrystal electron diffraction (MicroED). Additional highlights include fringe-free imaging for the acquisition of more usable images per foil hole, increased throughput compared to other commercially available optical alignment solutions and a new enclosure and hardware


compared to prior models.


The Thermo Scientifi c Glacios 2 Cryo-Transmission Electron Microscope (Cryo-TEM) is a powerful microscope with new automation and high-resolution imaging capabilities designed to help cryo-electron microscopy (cryo-EM) researchers of varying experience levels accelerate structure-based drug discovery. This advanced, fast and cost-effi cient method for drug design may enable customers to accelerate the pace of research for debilitating disorders like Alzheimer’s, Parkinson’s, and Huntington’s diseases, as


This next generation solution can generate <2 angstrom 3D reconstructions and produce images faster than its predecessor. These capabilities can help users of all experience levels increase productivity at a time when rapid innovation and emerging cryo-EM applications are placing increasing demands on expert microscopists.


“Using the Glacios 2 Cryo-TEM, we developed a workfl ow that enables us to determine structures of small, asymmetric complexes at high resolution and with high throughput,” said Basil Greber, principal investigator for The Greber Laboratory at the Institute of Cancer


Research and beta user of the new Glacios 2 Cryo-TEM. “Uncovering such structures provides us with detailed insight into inhibitor binding and suggests a mechanism for target selectivity in cancer therapeutics that we are currently testing.”


The new system also includes Thermo Scientifi c Smart EPU Software, which contains components needed for automated data acquisition, including microscope alignment and readiness assistance, plus an open API to allow for the development of solutions tailored to a user’s needs.


improvements built to offer enhanced performance


For pharma and biotech companies, the Glacios 2 Cryo-TEM offers high-throughput screening and imaging to enable


the routine


structure generation of druggable targets, including key targets of <120 kDA in size. For labs with growing demand for cryo-EM, the Glacios 2 solution helps increase accessibility to near atomic resolution structures, while improving ease-of-use and reproducibility across a variety of workfl ows.


More information online: ilmt.co/PL/Y0wp 58936pr@reply-direct.com


Interested in publishing a Technical Article?


Contact Gwyneth on +44 (0)1727 855574


or email: gwyneth@intlabmate.com Our articles are read by over 73,000 readers in print, online and via our Mobile App.


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