Laboratory Products 49 New Vacuum Nucleation Induction Method for Lab Freeze-drying Processes
Lyonuc is a new nucleation induction method developed by Telstar that facilitates scaling up and optimisation from a laboratory pilot scale to industrial scale. It is a solution for effectively inducing the start of nucleation in the freeze-drying process that enables research centres and pharmaceutical laboratories to run freeze-drying process more effi ciently, increasing the productively and improving the batch uniformly.
Particularly effective when testing and developing new recipes, Lyonuc is a standard option for LyoBeta, the range of twin-vessel pilot-scale freeze dryers designed by Telstar for research, development and scale-up of recipes for pharmaceutical freeze-drying processes.
The LyoBeta range is characterised by attributes of fl exibility, high performance, and small footprint required in a laboratory unit, including advanced process control systems, management software and interface features.
This new nucleation induction method developed by Telstar reduces the duration of the primary drying cycle. The vacuum-induced nucleation produces a change in the solid structure of the solution and manages to homogenise the moment when the freezing starts so that all the vials nucleate at the same time in a few seconds, instead of taking 30-45 minutes which is how long the spontaneous nucleation process typically takes. This method based on controlling the temperature and pressure and inducing the start of the freezing phase, also ensures the uniformity and homogenisation of the vials in all the batches, respecting the product’s physiochemical properties.
The nucleation induction method can be adapted to any type and model of freeze-dryer. Unlike other methods where it is necessary to add gases external to the process or use decompression processes requiring special equipment, this new method only requires controlling the temperature, vacuum, and time. This new method is particularly focused on long duration freeze-drying cycles, where the benefi t of reducing the drying time is much greater.
More information online:
ilmt.co/PL/M2wa 58937pr@reply-direct.com
Purge Function Enhances Density Meter Cleaning
Special attention is needed when it comes to cleaning the measurement cell and tubing of oscillation type density meters after the measurement of viscous or otherwise hard to remove samples. In addition to liquid cleaning operations that use solvents such as water and ethanol, Kyoto Electronics Manufacturing’s DA-800 series of density meters also employ a ‘Purge’ operation, that helps evacuate sample matter from the cell and tubing by directing air through the system. This Purge function is very useful in a number of scenarios.
Viscous and otherwise hard to clean samples are diffi cult to remove with a single cycle of liquid cleansing, requiring extra time and solvent for their full discharge. You can decrease this time by using the Purge function following measurement to expel sample from the system in preparation for cleansing with solvent. This will also help you to reduce the amount of solvent you use, benefi ting the environment and your wallet alike.
In some applications, it is desirable to perform post-measurement cleaning using sample liquid instead of solvent cleansers. In doing so though, you risk contaminating your next measurement specimen with that of the sample liquid used for washing. Using the Purge function following the liquid clean in this scenario will virtually eliminate the risk for contamination.
Kyoto Electronics Manufacturing’s DA-800 Density Meter family will save you precious time and money, so that your laboratory can operate with higher effi ciency. More information online:
ilmt.co/PL/eVww
58945pr@reply-direct.com ADVERTORIAL New Temperature Control Systems with Natural Refrigerant
The new PRESTO A38, A41, W41, A70, and W93, W93x process systems with natural refrigerant. These environmentally-friendly models work with the natural refrigerants propylene (R1270) or ethane (R170), and can be used in a wide range of applications. The cooling capacity of the new temperature control systems ranges from 0.8 to 20 kW at a working temperature of 20°C.
PRESTO A38/A41: Julabo’s air-cooled PRESTO A38 and PRESTO A41 process system uses environmentally friendly, natural refrigerant. It combines high performance and a very compact design with all the advantages of the PRESTO series for a working temperature range from -45°C to +250°C.
PRESTO W41: Julabo’s water-cooled PRESTO W41 process system uses environmentally friendly, natural refrigerant. It combines high performance and a very compact design with all the advantages of the PRESTO series for a working temperature range from -45°C to +250°C.
PRESTO A70: The air-cooled PRESTO A70 is Julabo’s most compact 2-stage process system and offers high cooling capacities for lowest temperatures down to -75°C.
Premium process systems for perfect temperature simulations
PRESTO W93: W93 process systems offer users high cooling capacity for dynamic applications even in the lowest temperature ranges. They work with natural refrigerants and are also very energy effi cient thanks to state-of- the-art technologies.
PRESTO W93x: W93 process systems offer users high cooling capacity for dynamic applications even in the lowest temperature ranges. They work with natural refrigerants and are also very energy effi cient thanks to state-of- the-art technologies
More information online:
ilmt.co/PL/9xGe 58795pr@reply-direct.com
Our highly dynamic temperature control systems in the PRESTO series cover all requirements for precise, reliable and reproducible temperature control of processes in the chemical and pharmaceutical industries.
Thanks to decades of experience and a wide range of accessories, our experts will work with you to fi nd the right engineering solution for your individual application. Even if this is not standard.
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