58 New Antimicrobial Bacteriological Barrier for Higher BSC Protection


The complete range of Telstar’s biological safety cabinets - Bio II Advance Plus and BiOptima - incorporates ZEROCOAT, a new antimicrobial bacteriological barrier, as a standard treatment applied in the work area. ZEROCOAT is a new photocatalytic treatment based on titanium dioxide which has been implemented by Telstar inside biological safety cabinets designed to operate with risk 1, 2 and 3 biological agents (viruses and bacteria or infectious material).


ZEROCOAT is the new treatment that provides a self-cleaning surface which breaks down organic matter when the light system is triggered. This activation, which can be either with white or ultraviolet light, makes organic matter oxidise naturally, safely and instantly at the molecular level. This provides it with particularly significant attributes in terms of bacterial protection, cleanliness and maintenance, durability and costs.


Existing antimicrobial coating systems for laboratory cabinets are composed of high levels of silver particles, which are applied exclusively to painted surfaces on the outside of the equipment. In contrast, the innovative ZEROCOAT treatment is incorporated on the inside of the cabin to fully protect the work surface and, among other variables, endows the stainless steel that surrounds the chamber`s interior with a high potential antimicrobial power.


The photocatalyst power of ZEROCOAT has been validated through an exhaustive battery of tests carried out in Telstar’s R&D department. The new treatment has been applied on different surfaces exposed to different types of light and wavelengths and the different organic compounds were subsequently checked for degradation. The results were then compared to tests carried out on untreated surfaces. In addition, the resistance of the new treatment to standard cleaning procedures in a cabinet and stability over a period of time has also been validated.


More information online: ilmt.co/PL/9p0x 57238pr@reply-direct.com


Cutting-edge Solution Creates Sustainable Alternative to Palm Oil


Asynt report how Revive Eco are using their ReactoMate ATOM jacketed lab reactor and CondenSyn MAXI system to scale-up an innovative patent-pending process that allows them to strip out an oil from waste coffee grounds which has a very similar fatty acid profile to palm oil.


Scott Kennedy, co-founder of Revive Eco said: “We are passionate about creating innovative solutions to protect the environment. Our coffee grounds extraction process is having a massive positive impact on waste reduction and production of accessible and sustainable chemistry resources already and this is just a start as we are investigating additional potential derivatives as well as the coffee oil.”


Dawn Thompson, Senior Process Chemist at Revive Eco commented: “Until relatively recently we were only able to make the coffee oil on a small scale in the lab. Growing awareness of the need for sustainability, particularly in the cosmetics and food and drink industry, meant the demand for our coffee oil and the coffee oil products was increasing rapidly. Asynt provided the ideal solution to our problem. Asynt’s Dr Kerry Elgie worked with us closely to understand our needs and provided us with a bespoke 20-litre jacketed reactor with the ATOM stand, overhead agitator, heater chiller unit and a large-scale condenser which is vital for us when we are isolating our coffee oil. This CondenSyn MAXI waterless condenser fits beautifully into our ethos at Revive where we strive to find new possibilities in old problems, and because it’s waterless we are quite literally saving thousands of litres of water per run. It’s also a lot a lot safer and a lot easier to run in the laboratory than a water condenser as we’ve eliminated the risk of water tubing leakages or accidents. All-in-all, the ReactoMate reactor and the CondenSyn truly allow us to make our green process sustainable.”


ReactoMate ATOM jacketed lab reactors are designed for process chemistries up to 30 Litres. These high-performance lab reactors come with almost endless customisation options to alter vessel dimensions, vessel and lid materials, automation and much more. The CondenSyn Waterless Air Condenser range is a proven ‘green’ replacement for water cooled condensers and suitable for greater than 95% of all chemical reflux applications.


View the full video interview with Revive Eco: ilmt.co/PL/O2xz More information online: ilmt.co/PL/gP64


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New Seed Train Platform Intensifies Upstream Processing


Merck have announced the launch of the BioContinuum™ Seed Train Platform, the industry’s only integrated and versatile solution enabling biomanufacturers to confidently move toward next generation bioprocessing using seed train intensification.


The platform consists of proprietary products for N-1 perfusion and high cell density cryopreservation (HCDC) including: the off-the-shelf Cellvento®


HCDC R&D single-use assemblies for high cell density cryopreservation.


4CHO-X Expansion Medium specifically designed for seed train expansion and N-1 perfusion, the Cellicon™ Perfusion Solution for superior cell retention, and closed processing-ready Mobius®


The integrated BioContinuum™ Seed Train Platform addresses the need for an efficient, consistent seed train that supports increased cell densities for intensification of the N production process. Specifically, it enables increased monoclonal antibody productivity in the production stage, reduces facility footprint and utilisation, and accelerates manufacturing timelines. The intensified process enabled by the platform is fully closed and compatible with both fed-batch and perfusion N-production stages, offering maximum flexibility. Efficiencies gained by seed train intensification reduce labour requirements and operational complexity, and because the process is closed, the risk of contamination is greatly reduced.


Seed train intensification is the first step toward optimisation of the entire upstream workflow, enabling biomanufacturers to realise the time and cost savings for fed-batch and perfusion processes. At a time when many manufacturers of monoclonal antibodies are seeking to add capacity to support growing demand, process intensification increases flexibility and reduces manufacturing footprint to realise their facilities’ full potential.


More information online: ilmt.co/PL/9x3y Liquid Flow Meter Calibration Capacity Expansion


Titan Enterprises has been performing all its calibration requirements in-house since 1994 using their positive displacement oil or water flow rigs. All flowmeters manufactured by Titan (except for the small beverage meters) are calibrated against traceable standards, tested and issued with a calibration certificate.


Twelve months ago, Titan decided to make the significant investment in a new calibration rig which would both increase their capacity and improve their capability to calibrate their liquid flow measurement devices. Having just received delivery of this new rig, it is being commissioned, calibration software installed, and will be ready to be put to use within the month.


Jeremy Thorne, Operations Manager at Titan Enterprises, commented: “Historically the production of our flowmeters has been limited by the flowmeter calibration capability. The new flow rig will increase our calibration capacity at the lower flow rates below 4 L/min. This will enable us to increase our production throughput as well as expanding Titan’s total range of flow calibration.”


Titan Enterprises use piston provers for flow meter calibration, our primary rigs rated from 0.002-40 L/min and 0.05-160 L/min. With the new rig our low-end flow calibration can be reduced to 0.05 ml/min. The calibrators use a piston within a smooth bore tube to act as a moving barrier between the pressurising gas and the displaced test fluid. All Titan flow calibrations are traceable to national standards and have real time temperature compensation to accommodate changes in the fluid properties. Piston prover systems are calibrated annually against certified weigh scales and are pneumatically or hydraulically driven to ensure a constant flow rate.


Like the main flow rigs the volumetric throughput for Titan’s new calibration rig is traceable to national standards via a water draw test. Flows as low as 0.05 ml/min may be calibrated using this rig, which has a repeatability value of ±0.02% and operates at an uncertainty of 0.03%.


Jeremy concluded: “Titan will also be increasing its production staffing levels to meet increasing demand, optimise our production rates and functionality that the new rig will give us.” More information online: ilmt.co/PL/O20g and ilmt.co/PL/gPJk


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INTERNATIONAL LABMATE - NOVEMBER 2022


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