48 New Centrifuge Connectivity Features Enhance Data and User Management


The newly launched SECURE-Spin connectivity features for the Thermo Scientific General Purpose Centrifuge platform enable greater user access control and data management in regulated laboratory environments, supporting compliance with 21 CFR Part 11 and Good Manufacturing Practice (GMP) standards.


The General Purpose Centrifuge platform is the most versatile benchtop centrifuge platform designed for applications that demand consistency, repeatability, and high throughput. The integration of Centri-Log Plus data management software provides traceable documentation for improved sample and process safety, offering accurate audit trails and centralised device monitoring.


Ergonomic design and ease-of-use make the General Purpose platform a robust, reliable solution for laboratories with multiple users. With newly available features, laboratory directors now have more control over the access privileges of specific users to meet their needs.


Key applications include regulated environments such as GMP labs, cell and gene therapy research, biotech, biopharma, and bioproduction labs. More information online: ilmt.co/PL/dkZZ


58728pr@reply-direct.com


Extended Granulated Product Portfolio Streamlines Processing Procedures Merck has expanded its granulated product portfolio with the launch of Sodium Chloride Granulated EMPROVE®


EXPERT Ph Eur, BP, ChP, JP, USP, a multi-compendial excipient with broad


application in both pharma and biopharma. Due to its granulated form, the new excipient provides reduced caking to facilitate processability, speed up manufacturing processes and increase operator safety.


Pharmaceutical manufacturing often requires the handling of multi-ton quantities of raw materials, such as buffers, salts, and stabilising chemicals. Any delays in handling can lead to non-desirable delays in production. For solid raw materials, handling issues arise if the material cakes or solidifies, thus becoming difficult to dispense out of the primary container, weigh accurately, and flow properly through processing machinery. This commonly results in negative impacts on manufacturing efficiency, process interruptions, and even quality deviations. Manual de-caking is often being employed to prepare solidified raw materials, but such a procedure wastes valuable time and poses a serious risk of injury to the operators.


Merck’s granulated materials help overcome these issues. Compared to bulk powders, granulated materials have better flowability and are easier to handle, with far less caking even after long-term storage. As the need for manual de-caking becomes obsolete or, at least strongly, reduced, operator safety can be significantly improved. Materials are condensed by compression force only, without the use of water or other additives. As a result, raw material characteristics are preserved, and the highest quality standards are met. With these properties, granules offer better processability, accelerate manufacturing processes and improve operator safety.


As the latest addition to Merck’s granulated portfolio offering, Sodium Chloride Granulated EMPROVE®


Potassium Chloride, and Ammonium Sulphate in granulated form, with more products to follow soon. More information online: ilmt.co/PL/xxg1


EXPERT Ph Eur, BP, ChP, JP, USP is available alongside Urea, Glycine, 58732pr@reply-direct.com


Optimised Lentiviral Vectors to Speed Up Your Research


AMSBIO offers a range of lentivirus production services to provide tailor-made products to support your research. Lentiviral vectors are a valuable tool for delivering target genes into most types of dividing and non-dividing mammalian cells in vitro and in vivo. Typically, production of custom lentiviral vectors is a laborious and challenging process, especially when high-titre lentiviral vectors are required. The custom lentiviral vector production service from AMSBO offers researchers a proven partner to avoid this bottleneck and speed up your research.


The AMSBIO custom lentivirus service includes the design and construction of the vectors, providing you with high quality viral particles on which you can rely. Offered for various constructs, researchers can choose from a wide range of expression vectors, depending on your desired research application.


This includes services to make ready-to-use shRNA lentivirus for your gene target and to clone your desired human cDNA ORFs into a lentiviral expression vector with options of various promoters, tags, and markers. In addition, AMSBIO offers ready-to-use anti-miRNA lentivirus for human and mouse miRNA, as well as miRNA lentivirus for any human or mouse miRNA listed in miRbase.


The latest custom lentiviral vector production services introduced by AMSBIO are Integrase-Deficient lentivirus for gene therapy research that reduce the risk of insertional mutagenesis and lentiviruses to help understand the mechanism of coronavirus (SARS-CoV-2) cell entry and how the viral tropism evolves over time.


More information online: ilmt.co/PL/Ddx4 and ilmt.co/PL/Wy0g 58383pr@reply-direct.com


Powerful Platform for Multiphasic Flow Chemistry Reactions


A new paper from Asynt, written by a multidisciplinary team of experts at the Institute for Process Research and Chemistry (iRPD) at the University of Leeds, describes how the fReactor flow chemistry system with add-on photochemical flow modules improves synthetic reactions commonly used in the preparation of drug intermediates.


In contrast to many tubular or plate-based flow chemistry systems, the Asynt fReactor with Photo Flow modules is especially well-suited to handling multiphasic solid-liquid and gas-liquid photochemical reactions.


The new paper describes a series of multiphasic Flow Chemistry reactions undertaken by iRPD researchers using the fReactor Photo Flow platform. Experimental data is provided for a series of relevant reactions including a benzylic bromination with a subsequent nucleophilic substitution step used in the synthesis of the anti-hypertensive drug Valsartan; a reaction where a reagent is used in slurry form to minimise solvent use resulting in significantly higher productivities that would otherwise be possible, an efficient oxidation reaction using air as a simple and safe oxidising agent, and photochemical synthesis of 1,2-diamines with productivities of over 50 times that possible by batch chemistry protocols.


Dr Francis from the iPRD commented: “The fReactor Photo Flow has provided us with an easy-to-use, powerful platform to undertake high productivity photochemistry in Flow Chemistry applications. Integrating the efficiency of flow processing with the advanced mixing of a continuous stirred tank reactor, we have found fReactor Photo Flow to be well-suited to performing multiphasic reactions allowing our chemists to explore continuous-flow processing, with little expertise required.”


The iPRD (https://www.iprd.leeds.ac.uk/) has a long track record of working with industry in developing chemical processes and equipment and in translating findings back to partners. In the described research - iPRD Professors Blacker, Marsden and Kapur, together with Dr Francis who carried out the practical work, worked closely with industry partners - Sterling Pharma Solutions and Redbrick Molecular - to identify relevant reactions to test the performance of the fReactor Photo Flow platform, before optimising reaction conditions.


Download a copy of the new iRPD paper: ilmt.co/PL/Q2rR More information online: ilmt.co/PL/kqem


58246pr@reply-direct.com


INTERNATIONAL LABMATE - NOVEMBER 2022


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72