Laboratory Products 51 Speeding up Development of a Hypoallergenic Haircare Formulation
Asynt report how award-winning formulation and development lab, Here2Grow Cosmetics & Homecare Labs, used the ReactoMate DATUM laboratory reaction vessel system in the development of a next generation clinical haircare product.
To tackle common scalp issues encountered by patients, a tricology clinic had been developing scalp therapy products in collaboration with formulation laboratories and manufacturers. However, with multiple active and incompatible ingredients, the formulations created were often unstable. Here2Grow was approached to tackle the issues through the creation of an effective shampoo and conditioner with hypoallergenic properties.
Dr Henry Brew, CEO of Here2Grow commented: “The formulation challenge posed by the tricology clinic required us to prepare a hair care product which involved a specific mixing, heating, and processing regime. By using the ReactoMate DATUM we were able to not only improve the formulation process and meet the specifications of the new product in a repeatable and consistent manner, but also save our company time and money.”
He added: “Throughout the haircare product formulation and development process we found the Asynt development team were knowledgeable, friendly, and responsive, helping us meet our deadlines. Beyond this specific project, we are using the ReactoMate Datum and laboratory reaction vessels from Asynt with a range of other apparatus to trial scale-up formulations, design formulation processes and perform fundamental research on various liquid materials and ingredients we are looking to integrate into formulated commercial products.”
Through the trialling of multiple prototypes, a stable formulation was produced which significantly reduced dandruff, itching, and fungal activity. Here2Grow’s success at developing a hypoallergenic shampoo and conditioner has made a valuable step forward in the improvement of scalp care products.
More information online:
ilmt.co/PL/JpxB 58727pr@reply-direct.com
How Clean is the
Measurement Cell of your Density Meter?
Sustainable Water Heater Adds Electric Functionality
Suncombe has announced the global release of the updated GMP Water Heating Skids incorporating the option to provide electrical heating utility in addition to steam and oil. The increased flexibility of the system enables its use in further GMP areas in the biopharma sector and other critical processing sectors.
Following extensive work with blue-chip clients and sector partners, who requested the ability to incorporate sustainable technologies in their water heating applications, Suncombe offer options to incorporate electrical heat pumps, regeneration and recovery heating to achieve corporate sustainability goals.
With variable temperature settings up to 125°C and flowrates of 1,000 litres per minute or more, the versatile control system allows configuration of temperature controlled, regulated flowrate and pressure during heating, storing and distributing of hot water for process and utilities. Encompassing traditional and innovative processes and technologies, the updated GMP Water Heating Skids incorporate an advanced control system built to GAMP guidelines, with 21CFR part11 compliance with audit trails and user access controls by passwords.
Proper cleaning of a density meter’s measurement cell is vital in achieving the most precise results possible as insufficiently cleaned cells lead to inconsistent and inaccurate measurement results. It is crucial to choose the correct cell cleaning liquid/s for your sample, and subsequently perform proper cleaning and drying operations. Measuring samples containing proteins such as dairy products and beer, often leads to measurement inaccuracies because proteinaceous substances accumulate in the cell when cleaning is insufficient. For protein samples, cell cleaning requires not only ethanol and water, but also sodium hypochlorite, and needs an adequate soaking and drying protocol. Syrup samples have a high tendency to stick, so cleaning with warm water (e.g., 60?) and ethanol with drying is required.
As for manual cleaning, it can only be as effective as the user performing it, and the adequacy of cleaning will naturally vary with user skill. It is essential that the order of cleaning agents used, their respective amounts, and how long cleaning steps are performed are all kept strictly uniform, which is difficult to achieve satisfactorily in manual cleaning. To cater to these cleaning challenges, Kyoto Electronics Manufacturing have created the DA-800 series of oscillation-type Density Meters, able to perform automatic, sequential cell cleaning using up to 3 different cleaning liquids at a time. When measuring samples containing proteins for example, you simply set the cleaning liquids to water, ethanol, and sodium hypochlorite. After sampling, pressing start initiates the sequence of measurement, cell cleaning (3 liquids) and drying, ensuring consistent, superior cleaning every time.
The DA-860 in accordance with ISO5725, boasts accuracy to 3x10-6g/cm3, repeatability of 1x10- 6 g/cm3 and reproducibility of 2x10-6g/cm3, complying with FDA CFR21 Part 11, allowing you to analyse, for example, food & beverage, petroleum, and pharmaceutical products with the utmost confidence.
More information online:
ilmt.co/PL/zOnQ 58434pr@reply-direct.com
Designed to comply with ASME BPE (Bioprocessing Equipment), the international standard for the design and construction of equipment intended for use in the manufacturing of biopharmaceuticals, they include compliance with the 2D deadleg rule, full drainability, full traceability and are suitable for validation.
The GMP Water Heating Skids, with capacities varied to suit a wide range of hot water supply applications, are equipped with controls and interlocking functionality to ensure water supply is constantly maintained at the required quality. HEPA sterile filters are incorporated to ensure that water quality is maintained in the system envelope.
Fully certified, the cGMP designed systems comply with all legislative and safety standards. Available in standard or bespoke versions, they are highly efficient and incorporate GAMP, ASME BPE, FDA and ATEX guidelines.
Developed to incorporate ‘Lean Manufacturing Principles’ ensuring that waste is minimised and efficiency is maximised, GMP Water Heating Skids are manufactured from 316L certified stainless steels and incorporating high quality components. The units can be fully thermally and chemical decontaminated for maintenance and the maintenance operations have been incorporated on the system display screens (HMI – Human Machine interface).
More information online:
ilmt.co/PL/gPA9 and
ilmt.co/PL/L2xP 58915pr@reply-direct.com
BiOptima biosafety cabinet range evolves and expands with the new EXA & ONE
Including ZEROCOAT the new antimicrobiological treatment
The all new BiOptima ONE Class I and BiOptima Class II B2 microbiological safety cabinets complete the range of high end BSCs manufactured by Telstar.
New antimicrobial coating: reducing contamination risks where it really matters in all Telstar Microbiological Safety Cabinets
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Please contact
marketing@telstar.com or visit our website
www.telstar.com for more information on this great Telstar product.
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