70


LABORATORY PRODUCTS


Biopharmaceutical Manufacture in Miniature liquid handling


The Biomolecular Separation Engineering group at the Karlsruhe Institute of Technology, Germany, is using the Tecan Freedom EVO®


workstation, equipped with the Te-Chrom™ module and Atoll’s 96-array MediaScout®


RoboColumn system, to create a fully automated


chromatography platform for biopharmaceutical process development. Professor Jürgen Hubbuch explained the team’s research strategy: “We are using automation to help us learn as much as possible about processes before synthesis and scale-up, aiming to significantly enhance process performance and reduce production costs. Tecan’s Freedom EVO workstations offer unrivalled flexibility for integration of new hardware components developed in-house, and a very high level of space on the deck of the instrument.”


“One of the main tasks performed on our Freedom EVO workstations is assessing chromatographic separations of new biopharmaceuticals using Atoll’s 96-array MediaScout RoboColumns. The combined Tecan/Atoll solution allows us to generate a large amount of data within a short time frame, and automation permits us, for the first time, to exploit Design of Experiment (DoE) strategies, combining short experimental time and low material consumption. This not only cuts the development time for process optimisation significantly, but also gives a much better understanding of the process”.


Circle no. 211


Raising the Temperature Bar Again Circle no. 212


Precision thermometry manufacturer ASL has upgraded its market leading range of AC bridges with the launch of the F252 as a successor to the highly popular F250. ASL has been producing the industry’s leading high precision thermometers and temperature bridges for over 40 years. Its equipment is used for primary and secondary calibration verification, process monitoring, sterilisation and validation work by some of the world's most demanding end users including NASA, Boeing, Shell, Esso and all International Standards Laboratories including the National Physical Laboratory.


The ASL F250 Precision Thermometer has been a leading reference temperature standard worldwide for a number of years. Thanks to further advances in technology, ASL has now replaced it with the F252, which is the fastest commercial AC Bridge of this precision class and faster than any DC bridge of similar specification.


It boasts accuracy to within +/-0.01ºC (full range) and resolution of 0.001ºC (0.0001Ω) with a resistance range of between 0 - 400Ω. It is also the first AC Bridge to be launched with ‘smart probe’ capability.


The F252 also comes with two channels as standard, but four and six channel variations are available with each channel able to work with up to 72 user-defined probes so providing spot on calibration. The F252 also offers single, differential and alternative measurement modes. The establishment of the RoHS Directive (Restriction of Hazardous Substances) across Europe in 2006 prompted a review of all thermometry devices. The tight restrictions placed on lead, mercury and cadmium have meant that all thermometer manufacturers have had to adapt some of their approaches. The F252 is capable of measuring temperature ranges to meet ITS90, CVD, EN60751 & IEC751 standards and results are delivered via a LCD backlit display with large numeric, statistical or graphical information. It also comes with USB interface as standard, but optional RS232, IEEE or LAN interfaces are also available.


Circle no. 214


Simplifying Complex Data Analysis


Syrris has introduced the Atlas Reporting Software to enable easy graphical analysis of sophisticated log files generated by the Atlas Base Unit, Atlas Software or Atlas Syringe Pump. Graphs can be created in seconds using the Wizard style software, which incorporates an easy-to-use, ‘drag and drop’ interface. Compatible with a range of Atlas products, the Reporting Software facilitates the fast analysis of resulting data for increased laboratory efficiency.


Circle no. 213


Log files from Atlas modules and other software are uploaded using a USB stick to the Reporting Software enabling graphs to be created, customised and printed, quickly and easily. Multiple files can be imported simultaneously, allowing various parameters from different experiments, such as temperature, pH, stirrer speed, flow rate and turbidity to be plotted on the same graph for comprehensive batch-to-batch analysis.


Wish you were here?


Promote your products to over 31,000 buyers... Contact: sales@intlabmate.com


The cost-effective Reporting Software can also display comments added by the user during the experiment, further increasing its usability. A line on the graph indicates when the comment was added, demonstrating correlations between any observations and the data. In addition, the Reporting Software allows log files generated by the Atlas Calorimetry Software to be interpreted quickly and easily.


The software enables fast and effective analysis of the thermal properties of the reaction with the click of a button. Furthermore, it imports raw data and automatically corrects for the sensible heat of addition and changes in UA. Graphs of reaction power, reaction enthalpy, overall process enthalpy, and sensible heat of addition are all automatically displayed alongside other process data, such as additions.


Circle no. 215


INTERNATIONAL LABMATE - FEBRUARY/MARCH 2010 - LABORATORY PRODUCTS


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88  |  Page 89  |  Page 90  |  Page 91  |  Page 92