72 SKIN CARE Fasting-mimicking effect of Clarivine
0 -1 -2 -3 -4 -5 -6 -7 -8
After 28 Days
40 35 30 25 20 15 10 5 0
* After 56 Days * -5 After 28 Days Placebo ■ Intermittent fasting ■ Clarivine ■ After 56 Days *** CAUCASIAN VOLUNTEERS ***
Figure 4: Left: Skin profilometry (Rz parameter) to assess grapevine secretome progressive results on skin roughness higher than fasting. Right: Skin antioxidant potential was assessed in the first skin layers
67.8% at day 28, indicating rapid and sustained improvement in the skin’s moisture retention capacity. These results contribute to a visibly
healthier, more supple, and luminous complexion—hallmarks of the glass skin ideal. In parallel, wrinkle depth was reduced to 27.4% at day 14 and down to 36.1% at day 28, confirming grapevine secretome’s effectiveness in improving skin smoothness and minimizing signs of ageing within a short application period.
Conclusion Grapevine secretome is a 100% natural active ingredient derived from Vitis vinifera stem cells, developed through sustainable plant biotechnology to support skin longevity and deliver the refined, luminous appearance associated with the glass skin trend. A cosmetic
Placebo ■ Intermittent fasting ■ Clarivine ■ After 28 Days
After 56 Days
0 -1 -2 -3 -4 -5 -6 -7
solution that is plant and biotechnology-based, COSMOS-approved, China-compliant, Halal certified, and respectful with the skin microbiota. By subjecting plant cells to a controlled
nutrient deprivation protocol, a hormetic response is triggered, leading to the production of a metabolically optimized secretome enriched in Plant Fasting Factors, including resveratrol, and signaling peptides. These compounds are naturally encapsulated in plant- derived exosomes to ensure enhanced stability and targeted delivery to skin cells. Functioning as a fasting-mimetic ingredient
at the cellular level, this innovation activates key skin renewal pathways such as autophagy, telomere preservation, and oxidative stress defence. It significantly reduces the accumulation of lipofuscin, the primary age- related pigment, while also decreasing melanin levels, contributing to a brighter and more even
BEFORE AFTER 28 DAYS
skin tone. Clinical evaluations in multi-ethnic panels
(Caucasian and Asian volunteers) confirm its efficacy in improving skin luminosity, hydration, tone uniformity, pigmentation, and wrinkle appearance. Bridging immediate aesthetic benefits
with long-term biological support, this active ingredient offers formulators a scientifically advanced solution for well-ageing, brightening, and regenerative skin care. It positions itself at the forefront of a new class of cosmetic actives that align consumer demand for visible performance, skin health, and sustainable innovation.
PC
References 1. Longo VD, Di Tano M, Mattson MP, Guidi N. Intermittent and periodic fasting, longevityand disease. Nat Aging. 2021; Jan;1(1):47-59
AFTER 56 DAYS
*
Figure 5: Grapevine secretome effectively reduces both global and dark spot pigmentation, delivering results comparable to those of fasting interventions
PERSONAL CARE September 2025
Figure 6: After the application of grapevine secretome, the skin appears less yellowish due to a reduction in lipofuscin, the pigment associated with ageing
www.personalcaremagazine.com
% of change vs T0
% of change vs T0 (Rz parameter)
% of change vs T0
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