SKIN CARE
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Animal-Free Media
C-Label products do not require animal-based media in their production process.
Animal Welfare
All interventions and procedures, in particular invasive ones, such as biopsies, must be demonstrably necessary, as well as being as painless and stress-free for the animals as
possible. No animals are killed in and for the entire procurement and manufacturing process.
GMO-Free
C-Label products do not contain GMOs, according to existing regulations (GMOs might be used in
the process but are no longer contained in the end product).
Antibiotics-Free
C-Label products do not require antibiotics in the production process and do not contain antibiotics.
Pathogen-Free
The cultivated component of C-Label products comes from a production process that is free of pathogens (such as Salmonella, E. coil, etc.) and is therefore itself pathogen-free.
Heavy-Metals and Plastics-Free
C-Label products contain virtually no heavy-metals or plastics.
Cell Extraction
When cells are derived from a living animal, this must be done in as painless and stress-free a manner as possible for the animal. Cell extractions are limited to as few as possible and any extractions need to be well-founded.
Figure 3: Key criteria for C-Label
frontier in skin care—offering ingredients that are not technically vegan but align with all vegan principles. These ingredients are derived from cultivated animal cells, without involving animal harm or exploitation. This approach enables the production of
cell-identical peptides and proteins that closely mimic the skin’s natural biology. Unlike plant-based ingredients, cultivated
cell-derived peptides can: ■ Deliver bioidentical signaling molecules that directly support skin regeneration ■ Stimulate collagen and elastin production more effectively ■ Offer multi-functional benefits through complex peptide blends While vegan ingredients are limited to what
plants can naturally provide, cultivated cell technology allows for the creation of highly targeted, biologically relevant compounds— bridging the gap between ethical sourcing and advanced skin performance.
The shift from plant-based to cultivated cell ingredients—and beyond From a biological perspective, vegan skin care ingredients are generally well-tolerated, particularly by individuals with sensitive skin or allergies to animal proteins. They offer natural benefits such as hydration, antioxidant protection, and anti-inflammatory effects. However, their efficacy can vary depending
on formulation and concentration. While plant-based alternatives are valuable, they often lack the precise biochemical properties of animal-derived compounds like collagen
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and elastin—key proteins that contribute to skin firmness, elasticity, and repair. In contrast, cultivated cell ingredients are
developed through advanced biotechnology. These include bioengineered compounds such as collagen, peptides, and growth factors produced via cell culturing. Designed to closely replicate the biological activity of natural skin components, these ingredients offer enhanced performance due to their structural and functional similarity to human skin. For example, cultivated collagen peptides
can integrate more effectively into the skin’s extracellular matrix, potentially delivering superior anti-aging and regenerative benefits compared to plant-based substitutes. The comparison between vegan and
cultivated cell ingredients centres on efficacy, safety, and ethical sourcing. Vegan ingredients provide broad skin compatibility and align with cruelty-free values, offering natural nourishment and protection. Cultivated cell ingredients deliver high-performance results through biomimicry, supporting deeper skin regeneration and repair. By combining the gentle, plant-based
benefits of vegan ingredients with the precision and potency of cultivated cell technology, skin care formulations can achieve a new standard— delivering ethical, science-backed solutions that holistically nourish and transform the skin.
Conclusion ZelluGEN proudly stands as the first skin care product to receive the C-Label certification, setting a new benchmark for the industry in ethical and sustainable production process.
Produced in an ISO22716-certified facility, it is developed through a novel bioprocess that ensures full traceability and minimizes environmental impact. As the first skin care product featuring
cultivated cell technology, it represents the future of conscious beauty—where innovation meets integrity.
References 1. Lintner K, Peschard O. Biologically active peptides: from a laboratory bench curiosity to a functional skin care product. Int J Cosmet Sci. 2000;22(3):207–18
2. Gorouhi F, Maibach HI. Role of topical peptides in preventing or treating aged skin. Int J Cosmet Sci. 2009;31(5):327–45
3. Tang Y, Nie T, Zhang L, Liu X, Deng H. Peptides in Cosmetics: From Pharmaceutical Breakthroughs to Skin care Innovations. Cosmet. 2025;12(3); 107
4. US Patent Nos. US 11,306,342 B2; US 12,037,625 B2; US 12,110,528 B2
5. A Randomized, Placebo-Controlled Clinical Trial Confirms the Efficacy of Zellulin ZelluGEN in Enhancing Skin Hydration, Elasticity, and Firmness. SOFW Journal. 3 Apr 2025
6. C-Label. C-Label launched as a new certification for cell-based food production. 2025.
https://c-label.com/c-label-launched- as-a-new-certification-for-cell-based-food- production
7. Grand View Research. Vegan Cosmetics Market Size, Share & Trends Analysis Report. 2022.
https://www.grandviewresearch.com/ industry-analysis/vegan-cosmetics-market
September 2025 PERSONAL CARE PC
Cell Use C-Label promotes animal-free technologies wherever possible, avoiding the need
for constant cell extraction . Currently, only immortalized cells are permitted, which require only minimal, if any, resampling.
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