SKIN CARE
Novel biotech for advanced skin care
Òscar Expósito, Monika Buchholz, Victoria Vidal, Ana Gallego, Sandra Ruiz, Pau Riera, Daniel Luna, Maria Mas, Marta Gibert, Laura Cano, Sara Laplana, Tarik Ruiz, Raquel Ferreira, Alejandro Guirado - Vytrus Biotech
Fasting has emerged as a scientifically validated physiological practice with growing interest due to its broad-spectrum benefits on health and longevity. Accumulating evidence supports its role
in mitigating age-related dysfunction by modulating key metabolic and regenerative processes. In particular, fasting has demonstrated the ability to improve ageing biomarkers, enhance the activation of progenitor and stem cell populations, reduce systemic inflammation, and promote tissue regeneration. These effects position fasting as a potent biological mechanism for cellular protection, damage repair, and resilience enhancement. Rather than a transient wellness trend,
fasting is an evolutionarily conserved survival strategy rooted in natural biology. Throughout human history, fluctuating
food availability shaped our metabolic responses, leading to the development of adaptive mechanisms that not only enable survival during periods of scarcity but also confer regenerative advantages. This adaptive physiology has inspired novel therapeutic and cosmetic applications that mimic the fasting state at the cellular level. In this context, Vytrus Biotech introduces the
fasting-mimicking approach as an innovative cosmetic strategy to support skin health, resilience, and longevity. The concept of skin longevity has expanded beyond traditional anti-ageing perspectives to encompass the modulation of biological age, with the goal of maintaining functional and aesthetic integrity over time. Fasting, particularly in the form of
intermittent fasting and calorie restriction, has been shown to modulate key pathways associated with cellular maintenance and lifespan extension. These include the
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downregulation of insulin/IGF-1 signaling, enhancement of DNA repair capacity, activation of autophagy, suppression of chronic inflammation, and preservation of telomere length.1-5 By translating these insights into the field of
dermocosmetics, the fasting-mimetic paradigm opens a new frontier in skin regeneration and rejuvenation.
Harnessing plant intelligence: fasting-mimicking secretome Inspired by recent scientific insights on the systemic benefits of fasting, Vytrus Biotech has translated this metabolic phenomenon into the realm of cosmetics through the development of grapevine secretome —a
TABLE 1: COMPARISON BETWEEN THE EFFECTS OF FASTING AND METFORMIN ON AGEING MARKERS Ageing Process
Fasting-Induced Effect
Oxidative Stress & Inflammation Senescence (Cellular Ageing)
Mitochondrial Dysfunction Loss of Collagen & Elastin
Reduces ROS levels & inflammation, preserving skin health Prevents premature ageing by removing damaged cells
Enhances mitochondrial function for sustained energy production
Stimulates fibroblast activity, maintaining skin structure
Pigment Accumulation (Lipofuscin & Melanin) Reduces cellular waste buildup for an even skin tone Telomere Shortening
Protects telomeres, extending cellular lifespan
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biotechnological active that mimics fasting- induced shifts at the skin cellular level. By harnessing this natural adaptive
intelligence, grapevine secretome aims to promote visible improvements in skin luminosity, and overall resilience and rejuvenation, while acting at a deeper biological level to stimulate longevity- associated mechanisms and improve longevity markers in human skin cells. This innovative ingredient is obtained from
the stem cells of Vitis vinifera, a perennial plant renowned for its exceptional lifespan, regenerative capacity, and metabolic resilience. Under meticulously controlled biotechnological conditions, these stem cells are cultured in a nutrient-restricted environment, effectively simulating an intermittent fasting state. This strategic deprivation triggers a
hormetic response—a beneficial adaptive stress reaction—leading to the biosynthesis of a unique profile of Plant Fasting Factors, resulting in the generation of a complex fasting-induced secretome, rich in longevity- promoting bioactives (resveratrol, biopeptides, and other compounds) encapsulated in natural plant exosomes for optimal efficacy. As described above, Vytrus Biotech
developed a specialized production process September 2025 PERSONAL CARE
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