60 SKIN CARE
the commissioning of a clinical study to evaluate the benefits of a finished formulation containing the botanical co-extracted material at 3% (or a placebo) on a panel of 60 participants aged 30-65 that applied it to their face twice daily for 12 weeks. At baseline, four weeks, eight weeks, and
12 weeks, the participants were examined using Elastimeter and Cutometer instruments that quantitatively assessed their skin elasticity and firmness, respectively. Both the Elastimeter and Cutometer
results demonstrated a trendline of continual improvement with the co-extract starting at the four-week timepoint that was sustained through to the conclusion of the clinical at 12 weeks (Figure 6). The instrument data was further supported
by expert grading that showed progressive increases in skin smoothness, texture, and visible firmness with concomitant reductions in forehead lines, crow’s feet, under eye lines, and glabella lines. Unexpectedly, there was an observed
recuperation in overall skin tone. These macroscopic augmentations in youthful skin appearance are highlighted in the participant panel images shown below (Figure 7).
Conclusion Discovering natural solutions to act as countermeasures to multiple facets of biological ageing is a significant undertaking that sometimes results in truly exciting findings. Furthermore, it is exceedingly rare to identify planted-based substances that are able to not only address one but many aspects of the skin ageing process. Herein, we have elaborated upon a
dual botanical extract that ameliorates the negative impacts of at least four distinct hallmarks of ageing: chronic inflammation (inflammaging), altered intercellular communication, epigenetic alterations, and diminished proteostasis. These benefits appear to be promulgated by the material’s activity focusing on the DEJ, one of the most
A B
Botanical Co-Extraction Cutometer®
Botanical Co-Extraction ElastiMeter™
20 15 10 5 0
-5 *** ***
3% Active ■ Placebo ■
***
35 30 25 20 15 10 5 0
* 4 weeks 8 weeks 12 weeks * p<0.05 **p<0.01 ***p<0.001 -5 ***
3% Active ■ Placebo ■
***
***
4 weeks
8 weeks
12 weeks * p<0.05 **p<0.01
Figure 6: Clinical study of finished formulation containing the dual botanical extract. A. Elastimeter evaluation. B. Cutometer evaluation
critical interfaces in the skin architecture. The combined laboratory and clinical data
strongly supports that this combinatorial substance will assert a rejuvenating impact on skin tissue, with increased elasticity and resiliency.
References 1. Birch HL. Extracellular Matrix and Ageing. Subcell Biochem. 2018; 90: p.169-190
2. Briggaman RA, Wheeler CE Jr. The epidermal-dermal junction. J Invest Dermatol. 1975; 65(1): p.71-84
3. Langton AK et al. The impact of intrinsic ageing on the protein composition of the dermal-epidermal junction. Mech Ageing Dev. 2016; 156: p.14-6
4. Jin S et al. Hallmarks of Skin Aging: Update. Aging Dis. 2023; 14(6): p.2167-2176
5. Li JJ et al. The genus Rumex (Polygonaceae): an ethnobotanical, phytochemical and pharmacological review. Nat Prod Bioprospect. 2022; 12(1): p.21
6. Cui Y, Xie H, Wang J. Potential biomedical PC
properties of Pinus massoniana bark extract. Phytother Res. 2005; 19(1): p.34-8
7. Cui YY et al. Effects of Pinus massoniana bark extract on cell proliferation and apoptosis of human hepatoma BEL-7402 cells. World J Gastroenterol. 2005; 11(34): p.5277-82
8. Gelse K, Poschl E, Aigner T. Collagens-- structure, function, and biosynthesis. Adv Drug Deliv Rev. 2003; 55(12): p.1531-46
9. Trebacz H, Barzycka A. Mechanical Properties and Functions of Elastin: An Overview. Biomolecules. 2023; 13(3)
10. Cai L et al. The Role of the Lysyl Oxidases in Tissue Repair and Remodeling: A Concise Review. Tissue Eng Regen Med. 2017; 14(1): p.15-30
11. Cenizo V et al. LOXL as a target to increase the elastin content in adult skin: a dill extract induces the LOXL gene expression. Exp Dermatol. 2006; 15(8): p.574-81
12. Michaud M et al. Proinflammatory cytokines, aging, and age-related diseases. J Am Med Dir Assoc. 2013; 14(12): p.877-82
12-week Clinical Results with 3% Botanical Co-Extraction
1. Gorehead lines Glabella Lines
2. Crow's Feet Under Eye Lines
3. Nasolabial Folds
Panelist also saw improvements to: Even Skin Tone Visible Firmness Texture Smoothness
Baseline
4 weeks
8 weeks
12 weeks
Figure 7: Clinical images from 12-week study evaluating a finished formulation containing the dual botanical extract. Sixty participants used a finished formulation containing 3% of the botanical co-extracted product (or placebo) twice daily for 12 weeks. Representative high-resolution images of one of the study participants in the clinical study is presented with time points collected at baseline, four weeks, eight weeks, and 12 weeks
PERSONAL CARE September 2025
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