70 New Platform Provides a New Dimension of Information to Confocal Imaging
Leica Microsystems has announced the launch of its flagship new confocal microscopy platform, called STELLARIS. The platform will significantly improve how scientists are able to capture three-dimensional images of living cells and tissues.
STELLARIS gives access to lifetime-based information in every experiment, in parallel with common intensity imaging approaches. Scientists will find that the unique TauSense lifetime-based imaging modes open up the potential to discover more. These modes complement a multitude of new ways to explore the function of molecules in their cellular context and help, for example, separate fluorophores even when their emissions fully overlap. Another benefit is that the number of simultaneous detection channels can be expanded by using lifetime-based information. Access to this advanced imaging information takes just one click. The new smart user interface, ImageCompass, ensures that scientists have the productivity to do more, as setting up even complex experiments is now much easier and more intuitive than ever before.
STELLARIS offers significant enhancements compared to existing confocal systems on the market. The enhanced sensitivity in the blue-green range (PDE > 55%) improves the detection limits and dynamic range for the most commonly used fluorophores. The extension of the detection range to the Near Infrared (NIR) provides up to 67% more dynamic range compared to current state-of-the-art detectors. The NIR extension allows for additional freedom when selecting dyes and up to three additional colours. The new detector generation in combination with the renowned Leica spectral detection technology and a newly designed beam path to maximise transmission efficiency, enables efficient signal acquisition while valuable samples are afforded the lowest possible exposure to light. Ultimately, this facilitates ‘gentle’ live cell imaging, preserving sample integrity and improving reproducibility of results.
The integrated TauSense is an innovative set of imaging modes based on fluorescence lifetime without the need to add extra dedicated hardware. It enables scientists to differentiate between specific fluorescence signals and unwanted autofluorescence to improve the quality of the final image and separate fluorophores that could not be previously separated with spectral unmixing.
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ilmt.co/PL/ROE4 52776pr@reply-direct.com Nanoelectrical and Environmental Control Accessories for Large-Sample AFM Announced
Oxford Instruments Asylum Research announces the release of accessories enabling environmental control and nanoelectrical measurements on the Jupiter XR large-sample atomic force microscope (AFM).The accessories include the PolyHeater, for heating samples up to 300°C, the CoolerHeater, with a cooling/heating range of -30 to 120°C, a fluid cell and probe holder for imaging in liquid, and conductive AFM probe holders for nanoelectrical measurements.
“Many research fields require environmental control, for instance, to mimic real-life conditions or to explore thermal properties. Similarly, nanoelectrical measurements are crucial to fields including semiconductor materials, 2D materials, and other functional materials. These new accessories for Jupiter XR enable even wider experimental possibilities for multi-user, multi-disciplinary laboratories,” said Dr Marta Kocun, Product Manager at Asylum Research.
Jupiter XR features a fully-addressable 200 mm sample chuck, simple and intuitive software control of system setup including laser and detector alignment, automated optimisation of imaging parameters, automated multi-site imaging and analysis, and Asylum Research’s unique blueDrive tapping mode for improved tip lifetime and measurement repeatability. It is also the world’s most versatile large-sample AFM, incorporating Asylum Research’s extraordinary range of capabilities and accessories and a modular design that supports future expansion. The Jupiter XR is the ideal research platform for research environments, high-throughput industrial applications and failure analysis labs. No matter the application, no other large-stage AFM can match Jupiter’s ease of use, speed, performance and flexibility.
51889pr@reply-direct.com New Light Sheet Fluorescence Microscope Introduced
The high stability of Zeiss Lightsheet 7 enables researchers to observe living samples over extended periods of time - even days - with less phototoxicity than ever before. The new light sheet microscope can also be used to image very large optically cleared specimens in toto, and with subcellular resolution. The dedicated optics, sample chambers, and sample holders of Zeiss Lightsheet 7 can be adjusted to the refractive index of the chosen clearing method to observe large samples, even whole mouse brains.
Zeiss Lightsheet 7 is designed to match a multitude of conditions. Specimens with a size up to 2 cm, with a refractive index between 1.33 and 1.58, and in almost any clearing solution can be accommodated. The stable turnkey system allows acquisition of overview images as well as of data with subcellular resolution. Researchers can now perform fast and gentle LSFM imaging of optically cleared organoids, spheroids, organs, brains, or other specimens.
Zeiss Lightsheet 7 now features the high-quantum efficiency of pco.edge sCMOS detectors to enable observations of the fastest processes at the lowest illumination light levels. Scientists are able to obtain a real-life view of large samples without the adverse effects of excitation light on their biology. For vertically oriented specimens and highest frame rates, the CMOS detector Zeiss Axiocam 702 can be used. A special sample chamber provides heating, cooling, and CO2 to maintain the optimal environment for live-cell experiments. Adding Multiview and triggering options to control external devices makes it possible to observe live processes in an almost unlimited range of organisms.
Zeiss Lightsheet 7 brings LSFM imaging a step further to tackle a broad range of applications with best image quality. Newly designed optics and sample chambers allow users to adjust the optics to the refractive index of their samples. The new sample holder makes mounting larger specimens easier. Smart software tools assist in defining imaging parameters, such as light sheet and sample positions, the right zoom settings, tiles and positions as well as data processing parameters. All these new features go hand in hand with the reliable Zeiss combination of cylindrical lens optics and laser scanning to generate the illumination light sheet. The patented Pivot Scan technology delivers artifact-free optical sections for best possible image quality.
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New Precision Raman Microscope Launched
Edinburgh Instruments is delighted to announce the launch of the new RMS1000 Raman Microscope designed and manufactured at their global headquarters in Scotland. The RMS1000 Raman Microscope is an open architecture, research grade confocal Raman Microscope. It has been designed to be adapted to almost any modern, state-of-the-art Raman application. This high- end research tool has been built with no compromises; resulting in a system that stands alone in both specification and ease of use. Applications beyond Raman such as time-resolved fluorescence microscopy and fluorescence lifetime imaging (FLIM) are all possible with the versatile RMS1000.
Key Features include: integrated and external lasers; five-position grating turrets; two spectrograph options; truly confocal; four simultaneous detectors; internal Standards and auto-calibration; Ramacle® software; photoluminescence microscopy, time-resolved measurements, fluorescence lifetime imaging.
Users of the RMS1000 will also benefit from access to the KnowItAllTM Raman Identification Pro spectral library which is available for material identification and advanced analysis. Data acquisition methods such as single measurements, multiple and accumulated scans, kinetic scans and generation of maps (accessory dependent) are implemented by intuitive and user-friendly wizards.
Roger Fenske, CEO, said: “We are delighted to expand our molecular spectroscopy portfolio with the addition of the RMS1000. We have designed the RMS1000 in consultation with leading scientists in the field to meet the research needs of those working at the forefront of Raman spectroscopy. The RMS1000 is built on the foundations of our other confocal Raman microscope, the RM5; but, with a focus on increased flexibility and adaptability. In the same way that our modular FLS1000 photoluminescence spectrometer compliments our benchtop FS5.”
More information online:
ilmt.co/PL/6ZoE 53507pr@reply-direct.com
INTERNATIONAL LABMATE - NOVEMBER 2020
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