38 Sub Ambient Synthesis of Novel Gold Organometallic Complexes
Asynt reports upon the synthesis of novel Gold (Au) organometallic complexes for use by researchers in the School of Chemistry at the University of Bristol achieved using a DrySyn SnowStorm Reactor and DrySyn Splitter Manifold.
The aim of the research being undertaken at the University of Bristol was to create new Au(I) organometallic complexes for use in gold-mediated cross-coupling reactions. Subsequent transmetallation with an organozinc reagent and reductive elimination led to the formation of products with new C-C bonds.
Researchers at the University of Bristol invested in a DrySyn SnowStorm Reactor fitted with DrySyn vial inserts to give them the capability of performing up to 12 low temperature reactions in parallel at a reliable and consistent temperature. By connecting the SnowStorm Reactor to a DrySyn Splitter Manifold the group were also able to utilise the recirculating chiller with other equipment in the lab, maximising their use of resources.
Mr Jamie Cadge, a PhD researcher in the Russell Group at the University of Bristol School of Chemistry commented: “Synthesis of gold complexes and performing multiple gold- mediated cross-coupling reactions is challenging chemistry. We found that certain steps required stable, low temperatures to be successful. Making use of three vial inserts in the SnowStorm Reactor meant that we could perform multiple reactions at the same time. Consequently, we are able to screen varying conditions for these cross-couplings with different substrates. The recirculating chiller unit and manifold supplied with the DrySyn SnowStorm has also allowed us to improve the environmental impact of our lab we as are no longer reliant on the use of multiple condensers which use tap water or dry ice-cold fingers.” Mr Cadge added: “I would recommend the DrySyn SnowStorm Reactor to other researchers as it enables multiple reactions to be reliably performed at consistent low temperatures in parallel.”
The DrySyn SnowStorm Reactor from Asynt offers an attractive solution for scientists looking to undertake low-temperature chemical reactions and studies (-30 to +150°C). Unlike traditional reaction cooling methods, accurate and prolonged temperature control on a DrySyn SnowStorm is regulated by an external thermostatic circulator. The use of such a temperature control system not only eliminates the risk of temperature fluctuations due to perishable coolants but can also improve your labs sustainable use of resources.
More information online:
ilmt.co/PL/P1rO 53232pr@reply-direct.com
Specialist Cryogenics for Safe and Reliable Pharmaceutical Freeze-drying
Lauda has completed a cryogenic cooling system for use in a pharmaceutical freeze-drying plant. The order was placed by Martin Christ Gefriertrocknungsanlagen GmbH who relies on the expertise of Lauda for the reliable provision of the deep-freeze environment.
Precise temperature control for the freeze-dryer is provided by a Lauda Kryopac Secondary Circuit Unit, which enables cryogenic reactions to be safely controlled. The possibility of individual temperature control of the shelves and the ice condenser is of great importance in this refrigeration system. The Kryopac, a heat exchanger specially developed for the evaporation of liquid nitrogen, is the heart of the system. Depending on the design of the Kryopac system, temperatures down to -115°C are possible in the secondary refrigerant oil circuit. The -80°C required for the freeze- dryer is therefore reached quickly and exactly to the degree. Other advantages include low investment costs and lack of waste products.
The heat technology of the Kryopac system produces a temperature-controlled liquid flow and are delivered as a compact, fully insulated, ready- to-connect system with a control cabinet. Precise temperature control, compact design and high plant availability were particularly important for Martin Christ’s customer. The Lauda A Kryopac Secondary Circuit Unit also meets these requirements without any problems.
The refrigeration system of the Kryopac system cools the shelves on which vessels filled with drugs are placed with a cooling capacity of 30 kW at - 80°C and freezes the pharmaceuticals in two and a half hours. Heat is supplied during evacuation, the removal of air by creating a vacuum. This results in a physical phenomenon called sublimation: The frozen water evaporates without liquefying. The drug is dried directly from the frozen state. The resulting water vapour is deposited on the ice condenser of the freeze-dryer in the form of ice crystals. The ice condenser is maintained at a temperature of -80°C by the Kryopac system. A complete freeze-drying process typically takes 48 hours.
The Kryopac system was initially completely tested at Lauda and then subjected to a further thorough inspection as a complete system at Martin Christ before the freeze-dryer was delivered to the end customer. As a result of the successful working relationship and implementation of this project, Martin Christ has already ordered two more Lauda Kryopac Secondary Circuit Units.
More information online:
ilmt.co/PL/LK9m 53264pr@reply-direct.com
New Quality Control Solution for Foam Prevention and Inhibition
Krüss has released the new Foam Tester, an instrument for testing liquids with respect to their foam formation and stability behaviour, focusing on quality control for foam prevention and inhibition.
The Foam Tester provides for standardised foam formation by electronically controlled gas flow and for objective result reading thanks to precise, electronic foam height detection. The measurement is carried out automatically and user-independently using easily adaptable automation programs.
By recording the total height of foam inside the measuring column and the liquid height beneath the foam, data are related to the absolute amount of foam and also give conclusive results for the liquid content and flow-out speed (drainage).
In many products and processes, such as cooling lubricants or spray painting, foam formation can directly affect quality. Even unstable foams are a problem when the liquid is in permanent motion and foam is created faster than it decays. Quality control for such liquids and the defoamers/antifoamers involved requires capturing the formation and stability of foam even if it breaks down quickly. For this purpose, the Foam Tester records the decay curve with a particularly high data rate. Moreover, automated cycles can reveal whether the foam level decays fast enough or rises from measurement to measurement. To adapt the conditions to the real process, measurements can be carried out temperature-controlled at up to 90°C and also with externally connected gases such as carbon dioxide.
The Foam Tester allows preparing the measurement in a few easy steps. The measuring cylinder is placed in the instrument with a single movement using the plug-in unit. The flexible system, which simply uses paper filters to provide the pores for foaming up, enables all components to be cleaned quickly. It also allows one sample to be prepared while another measurement is running in order to save time. The clear data management with the instrument’s ADVANCE software ensures gapless documentation of raw data and end results.
More information online:
ilmt.co/PL/vaKM 52988pr@reply-direct.com
Working Together to Help Fight COVID-19
Haier Biomedical is doing its upmost to support healthcare customers and users in the wider scientific community in the fight against the coronavirus. It is working closely with its manufacturing facility, supply partners, logistics companies and distributors to deliver the right COVID-19 appropriate product resources and support.
The new 75,000m2 , purpose-built manufacturing facility has been working 24/7 to [provide equipment to support customers around the globe]
(
https://ilmt.co/TL/WVAn). Like many of its sister companies within Haier Group, Haier Biomedical has worked tirelessly and in solidarity with each other and the wider community.
From materials and equipment assistance to PPE and personnel aid, Haier Biomedical has the knowledge, team and complete cold chain equipment and solutions required to deal with the needs to overcome this pandemic: Class 2 safety cabinets and laminar flow; ULT freezers (-86°C); Biomedical freezers (-25°C /-30°C /-40°C /-60°C); Pharmacy refrigeration; Sample Transportation Box; Vaccine and Blood Cold Chain; Laboratory including spark free refrigeration; LN2 More information online:
ilmt.co/PL/GpGW
storage containers and biobanks; Blood bank refrigerators; Wireless monitoring; CO2 incubator.
52892pr@reply-direct.com
INTERNATIONAL LABMATE - NOVEMBER 2020
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