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Green Flash Purification System now Available with Five-Year Warranty Selekt greener flash purification system is now available with a five-year warranty. The Biotage®


A focus of the Biotage®


Quality and reliability is a hallmark of Biotage products, and the Selekt flash purification system is no different. Biotage is pleased to announce that the Biotage®


Selekt flash purification system is a


compact instrument with a small bench top presence, and features a large touch screen with intuitive controls that are easy to use reducing the time needed for training.


Selekt system and Sfär consumables is to make purification greener by increasing the rate of purification whilst


Sfär complete portfolio of flash purification columns use spherical silica with a high surface area and consequently a higher loading capacity – enabling chemists to select a smaller column to perform the same separation, reducing both the amount of solvent used and the cost of the separation.


More information online: ilmt.co/PL/DmnP 52275pr@reply-direct.com


simultaneously reducing solvent usage. The instrument’s high flow and the high-pressure capability enables purification to be performed at a faster rate. In parallel, the Biotage®


Highly Reproducible Solid Phase Extraction


Porvair Sciences announce Microlute™ CP, a new generation of Solid Phase Extraction (SPE) 96-well microplates and cartridges that take SPE to a new level of performance by enhancing the reproducibility of analyte extraction and recovery from biological, environmental and chemical samples.


Unlike traditional loose-packed SPE methods, Microlute CP uses a hybrid structure, a solid interconnected network of evenly distributed pores combined with the retentive media. This unique design enhances the flow-through of samples to maximise interactions between analytes and the solid phase to deliver an unmatched reproducible SPE method that excels in performance, cleanliness and sensitivity.


, a porous plastic to form a structured interconnected network of even distributed pores. This hybrid technology results in the formation of a chemically active porous filter, a unique structure that overcomes inconsistencies and variabilities often associated with loose-packed methods.


Microlute CP microplates and cartridges benefit from a recent technological development which enables immobilisation of active media within the structure of Vyon®


The porous properties of Microlute CP allows for consistent and controlled flow of samples throughout the filter leading to overall better extraction and recovery performance. Meanwhile, the single solid structure used in Microlute CP plates eliminates the need for multiple porous filters for media support which can further disrupt flow rates and lead to unwanted material breakthrough. These technological advances have given rise to a new SPE methodology that extracts and cleans up your samples with enhanced reproducibility (< 4% RSD) meaning you can have greater confidence in results. With no flow- through or packing variability - Microlute CP is the perfect SPE sample preparation tool for high throughput analysis.


Other benefits of the efficient sample clean-up and concentration provided by Microlute CP include cost savings due to reduced need for replicating results; reduced analysis time due to the even emptying of wells; less solvent use compared to LLE and SLE methods as well as increased limit of detection (LoD) and quantification (LoQ). In addition, Microlute CP delivers cleaner samples thereby enabling you to achieve longer column life and reduced system downtime.


More information online: ilmt.co/PL/qgWV 52876pr@reply-direct.com


Total Nitrosamine Testing for Pharmaceuticals Introduced


As the European Medicines Agency (EMA) risk assessment deadline takes hold, Ellutia’s total nitrosamines pre-screening solution offers the pharmaceutical industry a simple, accurate and reliable test. This delivers a clear pass/fail result for apparent total nitrosamine content (ATNC) in minutes, allowing samples to be immediately cleared for processing or sent for further testing.


From April 2020, all marketing authorisation holders of medicines containing chemically synthesised active pharmaceutical ingredients (APIs) must conduct a risk assessment to evaluate the possibility of nitrosamines being present. Any sample showing an ATNC below the World Health Organisation (WHO)’s specified interim limit cannot possibly contain any one nitrosamine above the total level, and so can be deemed safe.


The Ellutia ATNC test is based on the 800 Series Thermal Energy Analyser (TEA) interfaced to a unique chemical stripping system. It allows pharmaceutical manufacturers to meet the requirements of the EMA risk assessment without needing to outsource testing of raw materials or of product at different stages of manufacturing.


Andrew James, Marketing Director at Ellutia, said: “Measuring apparent total nitrosamine content (ATNC) provides a benchmark of the nitrosamine volume in a product. Rather than embark on a lengthy analytical process to deliver detailed and speciated results in the first instance, the ATNC method screens only for the total nitrosamine content, both volatile and non-volatile compounds, and returns an analysis with a single clear peak. If this peak falls under the interim allowable daily intakes set by the World Health Organisation (WHO) for specific species of nitrosamines, the total nitrosamine content is permitted and the product is safe.


“In contrast, any sample found to contain an ATNC outside the safe level can be red flagged and sent for further analysis by a TEA interfaced to a GC or HPLC to individually identify the species and quantify the presence of nitrosamines such as NDMA. The risk assessment requirement from the European medicines agency means that pharmaceutical manufacturers need to take a serious look at potential nitrosamine contamination in their product lines. In America, too, the US Food and Drug Administration (FDA) has also already acted to call in various drugs known as ARBs for testing.”


The TEA has become the industry go-to for nitrosamine testing in GMP manufacturing environments such as food safety and materials testing. Coupled with Ellutia’s chemical stripping system, the instrument is seeing take up in pharmaceuticals testing.


More information online: ilmt.co/PL/Lpm3 and ilmt.co/PL/xQp6 51713pr@reply-direct.com


New Industrial-scale Centrifugal Partition Chromatography System Announced Gilson is pleased to announce a new industrial-scale centrifugal partition chromatography (CPC) system: VERITY®


CPC Process. This is the solution for customers requesting larger capacity CPC systems with a


high return on investment. The new system is easy-to-use and has broad applicability, namely in the natural extract, cosmetics, and pharmaceutical industries. With the introduction of the VERITY CPC Process, Gilson becomes the sole end-to-end provider of CPC systems and services for lab, pilot, and now process scales.


The new VERITY CPC Process solution takes CPC to the next level, with a customisable rotor capacity from 1 to 5 litres that allow users to process several tons of samples per year reliably. The system minimises dead volume and offers adjustable rotation speeds, providing higher resolution. To complete the solution, Gilson offers the VERITY® accuracy and 0.5% repeatability, which delivers optimised production time, costs, and quality.


SKID that operates at a fast 3-litre per minute flow rate with 2%


Developed with safety and compliance in mind, the VERITY CPC Process already meets EU 2006/42/EU and 2014/34/EC ATEX directives while UL is coming in 2020. The system is controlled by a 21 CFR part 11-compliant software and comes with FDA-compliant spares and consumables.


The VERITY CPC Process is not only about instrumentation. With more than 100 CPC unit placements in industrial settings, Gilson has developed a unique network of CPC Service Engineers and CPC Application Specialists. All owners of the CPC systems hence benefit from local support to keep instruments running at peak performance and with applications tailored to serve their business strategy. With the VERITY CPC Process, Gilson blends laboratory demands for flexibility with manufacturing drive for profitability. More information online: ilmt.co/PL/n2JE


53106pr@reply-direct.com


INTERNATIONAL LABMATE - NOVEMBER 2020


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