Laboratory Products 49
Rapid Evaluation of Critical Reactions Supporting Contract Research and Manufacturing
Uniqsis, in conjunction with their exclusive USA distributor, Sentinel Process Systems, Inc, reports how a FlowSyn™ continuous flow reactor installed at Adesis Inc is assisting them in evaluating custom synthetic routes for compounds along with improving existing batch manufacturing processes.
Dr Hai Le, who leads the Adesis Flow Chemistry Group, said: “My group uses the Uniqsis FlowSyn for the evaluation of the best routes in terms of yield and economics for compounds of critical importance to our customers. Our approach is to evaluate hundreds of potential reaction pathways quickly and repeatably, always looking to provide the greatest value to our customers. Our ability to quickly identify the maximum value path is supported by the versatility of the Uniqsis FlowSyn family of products that enable tens of reactions per day that vary temperature, residence time and mole ratio by simply entering these parameters into a keypad and letting the automated FlowSyn system provide continuous product samples ready for analysis. In particular, the GAM allows for the rapid change-out to and from using reactive gases. No other tool on the market allows for this level of speed and versatility when evaluating gas-liquid reactions. The addition of the Uniqsis FlowSyn tool suite has enabled us to support the needs of our customers whose requirements for cost, quality and speed to market are of the utmost concern. Most recently, we successfully developed a critical flow process for a commercial-ready- chemical. The flow method doubles the overall yield, minimises stoichiometry of a starting material which require multiple synthetic steps to obtain, while decreasing by-product formation from 30% to 0.2%. This process can be scaled up to deliver hundreds of grams per day reproducibly.
FlowSyn is a versatile automated flow chemistry system and can be configured with up to 4 pump channels with a choice of 10ml/min, or 50ml/min pump heads for higher scale applications. It can be programmed to run 10 sequential reactions that deposits reaction product in vials ready for instant analysis. It may also be configured with any combination of up to 4 individual heated/cooled reactor modules. By selecting from the HotCoil™ and HotChip™ heated reactor modules, and the Polar Bear Plus Flow™ and Polar Bear Plus GSM™ cryogenic modules, the FlowSyn offers unrivalled flexibility. The FlowSyn continuous flow reactor can also be integrated with the Uniqsis Flow-UV™ inline UV-VIS spectrophotometer to monitor steady state conditions in real time.
More information online:
ilmt.co/PL/6ZdL 53085pr@reply-direct.com
Versatile Digital Handheld Refractometer Features an Onboard Library of 50 Commonly Used Scales
The new OPTi Digital Handheld Refractometer from Bellingham + Stanley offers versatile measurement of total dissolved solids and blend ratios of liquids in a highly reliable, premium quality instrument.
Thanks to its compact design and clever marriage of smart software and ergonomic hardware, OPTi refractometers are the perfect refractometer for use in the field, factory or laboratory. The OPTi features an easy-clean, stainless steel prism dish offering rapid temperature stabilisation and convenient cradling of sample compared to most optical refractometers.
The OPTi revolutionises the way in which digital handheld refractometers are supplied and purchased, giving customers access to an onboard library of 50 common scales including 0-95 °Brix, Refractive Index, °Baumé, Butyro, Colostrum Quality, Ethylene Glycol and many more. Up to three active scales are easily accessible by the user; with the onboard scale library just a few button presses away. Thanks to the vast range of scales and durable design, the OPTi refractometer is suitable for a wide range of applications; from the laboratory to the harshest of environments.
A unique AG Test Mode allows for the use of long-life non-sucrose based certified reference materials for measurement verification. A read delay can be applied to the ‘Read’ or ‘Zero’ functions to aid measurement stability. Temperature can be displayed in either Fahrenheit or centigrade, supporting use anywhere in the world.
Bellingham + Stanley, a Xylem brand, offer a complete range of handheld and laboratory refractometers suitable for measuring the concentration of solutions across many different industries including food and beverage, beer and wine, industrial, automotive, and life science.
More information online:
ilmt.co/PL/n2A0 53023pr@reply-direct.com
High Quality 8-Position Parallel Reaction Station
Asynt has introduced a second- generation version of its popular DrySyn OCTO reaction station that delivers the same outstanding performance, at the same price, with improved features and a new, more aesthetically pleasing, design.
Like its popular predecessor, the DrySyn OCTO Mk II is an 8-position reaction station that provides chemists with powerful magnetic stirring, heating, inert atmosphere and reflux, all within a compact footprint. The DrySyn OCTO Mk II is an ideal tool for chemists performing syntheses and screening reactions in parallel.
Martyn Fordham, Managing Director of Asynt, said: “Though our DrySyn OCTO users worldwide were delighted with the performance, versatility and value for money the product offered, as an engineer I thought that we could improve the products aesthetic design. Our new Mk II design employs improved manufacturing techniques to get rid of plugged drill holes, introduces engraved labels for reaction positions (A-G) and now includes high-quality stainless-steel fittings to improve user maintenance and reconfiguration. All-in-all, a great product is now even better.”
Accommodating individual reaction volumes of up to 6 mL, the DrySyn OCTO Mk II has been designed to use standard low-cost reaction tubes to minimise your expenditure on consumable items. To further increase your parallel synthesis productivity, up to 3 DrySyn OCTO Mk II reaction stations can be used together on a single standard magnetic hotplate stirrer, therefore enabling you to perform up to 24 simultaneous reactions.
More information online:
ilmt.co/PL/9Vrn 53233pr@reply-direct.com
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