60 Reliable Sterilisation of Coronavirus Particles
Exhaust air filtration in autoclave steam sterilisation is extremely important, especially in light of the current coronavirus epidemic. Tests show that the exhaust air filtration in Systec autoclaves reliably prevent hazardous aerosols from escaping during the autoclaving process.
Systec products filter exhaust air by means of an autoclavable sterile air filter inside a filter housing and a PT-100 temperature sensor. All air displaced from the autoclave is passed through the filter and, as a result, the microorganisms are retained in the filter. The filter is also sterilised ‘inline’ during the sterilisation process in order to inactivate the microorganisms contained in it. The temperature inside the filter housing is monitored by the PT-100 temperature sensor. During the heat-up and sterilisation phases, the condensate is retained in the pressure vessel and also sterilised safely. Exhaust air filtration and condensate sterilisation prevent any viruses or germs from escaping before the end of the sterilisation phase.
The filtering medium used by Systec GmbH is an autoclavable sterile air filter in the form of a PTFE membrane filter cartridge with a pore size of 0.2 µm. The filter cartridge is located in a pressure-resistant housing and can be replaced quickly at any time. The PTFE membrane is additionally protected by polypropylene nonwoven fabrics on the upstream and downstream sides. External support bodies and end caps made of a special, heat-stabilised polypropylene as well as internal support bodies made of stainless steel ensure exceptionally high thermal resistance and mechanical strength. The filters are monitored via a maintenance counter, with a replacement interval of 150 cycles.
To ensure a validatable filtration, the heating temperature of the autoclave is monitored throughout the process via the PT-100 temperature sensor (class A). At the same time, this sensor ensures that the filter cartridge is heated to a temperature that enables the safe inactivation of filtered particles. In the event of any deviation from the prescribed process sequence, the autoclave is put into a fault mode, which prevents the outflow of contaminated exhaust air. The integrated user management functionality prevents unauthorised access.
More information online:
ilmt.co/PL/e2Pp 52740pr@reply-direct.com
Why Pre-formulation Studies are Crucial to Successful Drug Development
It is vital to understand the behaviour of a new active pharmaceutical ingredient (API) under various stress conditions to provide a solid foundation for development of a robust dosage form which can survive processing and a prolonged shelf live. The result of a poor, or no, pre-formulation study could be increased time and cost of drug development, an unstable product, or worse. Efforts taken on comprehensive pre-formulation studies are more than repaid via cost and time savings.
Newly discovered proteins identified through genomics, proteomics, or traditional medical research have historically been utilised in drug development with minimal knowledge about their mechanisms of action, structural characteristics and biochemical properties.
Proteins are inherently unstable, which has potential to alter its desired form, which could significantly compromise not only the drug’s efficacy, but patients’ safety. This is why pre-formulation is such an essential part of the drug development process. It is the group of studies undertaken in early biopharmaceutical development, prior to formulation development, focused on discovering the physicochemical properties of a new drug molecule which could affect its performance and consequent dosage form. It provides a scientific sketch of the drug in development.
Having a clear understanding of a protein’s behaviour and awareness of any adverse effects related to a product, demonstrates the worth of conducting pre-formulation studies. Getting things right the first time is much more preferable to making costly mistakes and it is also a much faster route to market. Furthermore, patent expirations and a reduction in the development of new, first-in-class molecules over the past 15 years has occasioned the strategy of drug repurposing. This is yet another reason to conduct comprehensive pre-formulation studies. Many companies outsource pre-formulation studies to service providers such as the R&D consultancy division of the Biopharma Group.
More information online:
ilmt.co/PL/3L1v 45197pr@reply-direct.com
New Device Enables Rapid, Reproducible Cooling of Laboratory Samples
Asynt announces FroSyn - an innovative fluid-free cooling plate that enables rapid cooling of samples in vials or round bottom flasks (up to 500 mL) to below -60°C.
Designed in conjunction with temperature control specialists, Julabo GmbH, FroSyn represents a next generation sustainable alternative to using traditional ice and dry ice (CO2
) cooling baths.
Active temperature control, via. a Pt100 sensor positioned in the insulated base plate, allows the user to set a defined plate temperature (down to -70°C) and prevents temperature fluctuations over time. This innovative approach to sample cooling results in excellent reproducibility and improved reaction control. Unlike dry ice cooling baths that require constant attention, the stable and controlled sub-ambient performance of the FroSyn means that even overnight reactions can be performed with complete confidence.
Specialist insulation around the cooling probe and plate on the FroSyn improves performance, keeps the apparatus ice-free and helps eliminate the possibility of operator cold burns during operation. Positioning of the FroSyn on top of a conventional magnetic stirrer plate allows for efficient sample mixing during cooled experiments.
The FroSyn can be used with either a set of standard insets for round bottom flasks from 50 mL to 500 mL, or with custom manufactured reaction vial holding plates. The use of either weights and seals for the flask inserts, or an inerting dome with the vial plates prevents the formation of ice on the glassware. Other custom cooling accessories are also available to compliment different applications, for example a 4-position holding module for battery research and development.
More information online:
ilmt.co/PL/dmlK 52665pr@reply-direct.com
New Multifunctional Laboratory Centrifuge for Routine Laboratory Tasks
The new LMC-56 laboratory centrifuge from Biosan is a bench-top, low speed multifunctional centrifuge for routine laboratory tasks. The instrument is perfect for biochemical, cytological and immunological analyses making it prefect for sample preparation in research, biomedical and genetic laboratories. The precursor of this instrument was the LMC-3000 laboratory centrifuge which is well-known among users in Europe.
This new higher speed model offers a maximum 6,000 rpm or 3,160 g. The new bucket rotors, have a maximum total capacity up to 400 ml. A wide selection of up to 13 rotors are available.
The LMC-56 laboratory centrifuge features automatic rotor recognition and a setting allowing users to set the maximum speed for each rotor type. Improved ventilation of the working chamber reduces tube heating during centrifugation. Operators have the choice of several types of acceleration and braking.
More information online:
ilmt.co/PL/e2vk 52891pr@reply-direct.com
INTERNATIONAL LABMATE - NOVEMBER 2020
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76
