Spotlight Biotechnology & Immunology


New Storage Management Platform BioSampling Systems®


has the ambition to become one of the world leaders in serum bank storage and manage (storage and release of


biological samples, sample library…). BioSampling System provides full sample management solutions (software, automate, readers, accessories, consumables). They are taking action to improve sample management technologies with their 3S® (storage at -80°C/-196°C).


will be held at the MipTec exhibition in Basel, Switzerland from the 20th to the 22nd September 2011. The new NEO Sample Management® system (storage at -20°C/-80°C) and ICE®


Their aim is to make customers’ laboratories safer and to improve the quality of their sample storage. The official launch of the NEO Sample Management®


is designed to guarantee the traceability of the samples, ensure sample integrity, improve tracking efficiencies and finally optimise space to satisfy users biobank’s needs.


The BioSampling Systems high performance NEO Sample Management portfolio gives users reliable medium and long-term storage management of their biological samples. The high-speed NEO Robot is ideal for aspirating and dispensing both microlitre and sub-microlitre volumes into the NEO Plate96 for high quality biobanking.


Their system can be used in different domains such as clinical, diagnostics, biotechnical, environmental, food quality and safety testing. Circle no. 146


Breakthrough in Bioprocess Optimisation for Biologicals


For new biologicals and biosimilars, the innovative Spedia-NMR™ technology from Spinnovation Biologics provides a real advantage for optimising cell cultures, monitoring and standardising manufacturing processes in preparation for larger scale production. Within the past four months, this has been validated by 37 companies developing biologics or delivering services to this industry.


This premium nuclear magnetic resonance (NMR) analysis service rapidly identifies a wide selection of feed components, metabolites and toxic compounds in culture media. By comparing media profiles from different cell culture batches, Spedia-NMR™ identifies how a cell consumes and metabolises the media along the culture process. This allows the composition of the media to be fine-tuned to improve cell viability, reach highest yields of biologic product and perform rapid process troubleshooting.


Spedia-NMR™ technology has gained rapid popularity in both the biotech research and manufacturing communities because of the speed of analysis (analyse in a matter of minutes/hours, delivery of service within five working days) and the valuable information it provides in assisting process development.


Spedia-NMR™ technology is available on a fee-for-sample or as a contract service to all biotech. Users range from medium to large biotech companies and some academic clients use this specialist service in their protein therapeutics research. The true adaptability of Spedia-NMR™ analysis has led to its application across a range of cell systems and production platforms including: CHO, stem cells and virus production platforms. Spedia-NMR™ is designed to perform rapid, high throughput analyses of cell culture media batches and feed-batches in a very cost-efficient manner, using fully automated sample analysis and data processing.


Circle no. 147


First Fully Integrated Micro Bioreactor System at Top US Pharma


New Epigenetics and Cell Biology Product Range


Porvair Sciences Ltd has announced that it has chosen the forthcoming Biotechnica 2011 exhibition in Hannover, Germany in October to launch a comprehensive range of new products for Epigenetics and Cell Biology.


Steve Knight, Marketing Manager, commented: "Visitors to our Biotechnica Stand A29, Hall 9 will have the opportunity to come to the launch of an Epigenetics / Cell Biology product range that uniquely combines top quality and value-for-money." He added: "For labs interested in these products we will be offering free samples for evaluation."


At this important meeting Porvair Sciences will also be showing the MiniSeal Plus™, its latest entry-level semi-automated thermal sealer developed for laboratories sealing small to medium batches of microplates. The versatile device is capable of producing an accurate and tight seal on any SBS proposed standard, deep well or PCR microplate from 3 to 62mm in height. For laboratories looking to remove the traditional drug discovery 'bottleneck' of solvent evaporation in microplates prior to analysis or reconstitution in buffer - Porvair Sciences' choice of 96-well, 384-well and robot compatible UltraVap™ sample concentrators will be of particular interest. Significant increases in sample throughput are achieved with the UltraVap through advanced evaporator head technology and an innovative manifold design, which directly injects heated nitrogen into each individual well of the microplate simultaneously. The system is proven to remove even the most stubborn solvents in just minutes. For heat sensitive and thermally labile samples the Ultravap™ may be operated in a unique two-stage mode combining rapid initial dry-down with carefully controlled final solvent evaporation. Porvair Sciences will also have on display a selection of its applications optimised microplates.


Circle no. 148


TAP Biosystems announced the first installation of its micro bioreactor system (ambr™) with integrated cell viability analyser in one of the world’s top 10 pharmaceutical companies. This walk-away system will be used to assist in predicting how antibody-expressing cell lines will perform in large-scale bioreactors. The ambr system was purchased by the major US pharmaceutical company then TAP Biosystems’ specialists integrated the customer’s Cedex HiRes cell analyser into the system’s workflow. The ability to manage their ambr system with cell counting from one central point is enabling the pharma company’s researchers to reproducibly control and evaluate the behaviour of their antibody-expressing cell lines at micro scale (10–15ml working volume). Unattended cell counts can be performed outside of normal working hours, supporting experiments overnight or at weekends, thus saving time and making significant productivity improvements.


The Spotlight could be on you! For more information, email: tamsyn@intlabmate.com


Using the ambr software, scientists at the pharmaceutical firm can control culture conditions; initiate on-line measurement of cell number and viability, and collect cell analysis data. They can also set up the ambr to make automatic feeds based on the integrated cell count data, providing a truly walk-away automated bioreactor system. Dr Barney Zoro, ambr Product Manager at TAP Biosystems, explained: "There is data which suggests incorporating a cell analyser into an automated cell processing workflow delivers more precise results, as the count variation that can occur between different sample handling practices, is reduced. Therefore, we are delighted to have successfully integrated a second type of cell analyser into the ambr system at such a major pharma because it offers researchers the opportunity to confidently run and control larger numbers of experiments, as and when they need to, without being constrained by the working day.” Zoro concluded: “For bioprocess scientists needing to accurately determine the optimum bioprocessing conditions to accelerate their cell line selection and process development, an ambr system with integral cell analysis capabilities is the perfect solution.”


Circle no. 149


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