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CHROMATOGRAPHY
GPC System Warms the Heart Of An Academic Polymer Scientist
“Good value and excellent performance is a combination that will warm the heart of any academic polymer scientist,” said Professor Kenneth J Wynne of the Department of Chemical and Life Science Engineering at Virginia Commonwealth University, when asked about his 11-year use of Viscotek gel permeation chromatography (GPC) systems from Malvern Instruments.
Professor Wynne’s research team uses the Viscotek TDAmax triple detection system to carry out routine GPC when developing and applying novel surface modifications to polyurethanes and other polymers.
Professor Kenneth J Wynne said: “The Viscotek TDAmax is extremely valuable because in our work on polymers we perform some syntheses which can lead to large molecules with two drastically different structures. GPC is critical in delineating the amounts of each structure and the Viscotek system we use employs quadruple detection that includes refractive index (RI), light scattering at both 90 degrees and low angle (LALS), and viscosity detectors. We use two fractionation columns in series that are carefully selected to effect good separation for low molecular weight species. Malvern supplies these columns too.”
“When I came to Virginia Commonwealth University to set up a new laboratory in polymer science more than a decade ago, I contacted two instrument suppliers,” explained Professor Wynne. “However, right from the beginning the Viscotek system worked really well, we were given an attractive offer, which was supported by a customer services department that made it a priority to help a faculty that was just starting out.. It was therefore an easy choice and one which I can look back on
11 years later with the knowledge that it was the correct one.”
Professor Wynne’s research is supported by the National Science Foundation, the Office of Naval Research and the VCU School of Engineering Foundation. As well as research into coatings that resist fouling in the marine environment, he and his research team work with very unusual ‘soft blocks’ called polyoxetanes. These modify the surface of polyurethanes to produce antimicrobial coatings that kill bacteria on contact without releasing toxins. The resulting polyurethane molecules can be used in biomedical applications for wound care or in vivo medical devices.
Circle no. 43
Highest Performing UPLC Ever Engineered
Waters Corporation introduced the new Waters® ACQUITY UPLC® UPLC®
I-Class System, the highest performing
system ever engineered taking UltraPerformance LC® separations technology to the next level. For scientists challenged by the most difficult separations, the ACQUITY UPLC I-Class features the lowest system dispersion and lowest carryover in the industry today.
Low dispersion maximises peak capacity thereby advancing chromatographic separations and optimising the performance of any mass spectrometer.
Keeping pace with today's most advanced laboratories, the ACQUITY UPLC I-Class System excels when analysing complex, sample-limited compounds. Sample-limited compounds include high potency medications, trace levels of food or water contamination, and (advanced) sophisticated biotherapeutics. These samples can represent complex separation challenges requiring an LC system that can maximise the benefits of sub-two-micron for faster throughput and optimised MS performance.
While there are many innovations built into the new ACQUITY UPLC I-Class, minimal system volume is a new key feature. Reduced system volume significantly decreases dispersion rates for reproducibly higher resolution and superior peak capacity.
Reduced dispersion and small peak volumes extend the sensitivity of any mass spectrometer. Additionally, low dispersion footprint allows users to reduce their separation cycle times without impact to the separation as resolution is maintained even for ballistic gradients lasting less than one minute. Also importantly, new design and materials dramatically reduce sample carryover effects, thus increasing user confidence in results.
The ACQUITY UPLC I-Class also features class leading flexibility and precise sampling capabilities. Depending on application needs, users can choose either the highest precision and lowest dispersion fixed-loop Sample Manager, or the world's first low dispersion variable volume Sample Manager with a flow-through needle design, which delivers high-precision injections, excellent sample recovery, and lowest sample carryover optimising the performance for even the most sensitive mass detectors.
Circle no. 45
Case Study Documents Cost-Saving API Residual Analysis
Phenomenex, Inc announces the publication of a case study, written by scientists at Pfizer, that demonstrates the results of a new method for residual API (active pharmaceutical ingredient) analysis. This new solution replaces 16 older methods for individual key ingredients, and has delivered cost savings of £320,000 (more than $516,000) per year. The method requires just one UHPLC instrument, using Phenomenex Kinetex®
1.7-micron core-shell columns, to resolve all 16 ingredients in just six minutes. In addition to instrument and time-savings, the method uses less solvent, reduces waste disposal costs and frees up lab analysts.
“High-volume laboratories, such as those in pharmaceutical QC, have an acute need to reduce operating costs and free up resources,” explained Jeremy Bierman, Brand Manager for HPLC products. “The Kinetex core-shell technology allows the development of faster and more efficient analytical methods to deliver significant cost and time savings.”
The Kinetex 1.7-micron column is the first and only sub-2-micron core-shell UHPLC column on the market and typically delivers efficiency gains of 15 to 20% over traditional fully porous sub-2-micron columns.
Circle no. 44
UHPLC Solution Combined With Advanced Autosampler Delivers Numerous Benefits
Shimadzu UK’s next-generation Nexera UHPLC system offers a number of ultra-high performance benefits including the lowest carryover, highest pressure rating, shortest autosampler cycle time and the highest injection volume precision, all with the flexibility of Open Access. The combined benefits lower the system’s Total Cost of Ownership (TCO) while delivering the highest level of productivity gains required by the most demanding application markets such as the pharmaceutical and food industries. The system is capable of running at high throughput with a 2300-plus sample capacity.
Offering precise solvent delivery, excellent reproducibility and near- zero carryover the Nexera UHPLC system is a green LC and ensures fully reliable ultra-high speed and ultra-high resolution analysis in all application fields. Shimadzu’s Nexera is a supremely flexible system and allows users to perform high-temperature analysis, automatic sample pretreatment and multidimensional LC separation.
Coupled with Shimadzu’s SIL-30ACMP autosampler, the Nexera UHPLC system offers the tightest integration with AB Sciex and Thermo Fisher mass spectrometry platforms. The SIL-30ACMP autosampler enables lower carryover performance and shorter cycle times than competitor systems.
“The Nexera UHPLC solution supported by the SIL-30ACMP autosampler is ideal for all users struggling with carryover problems causing re-analysis of samples and inducing extra costs. The faster autosampler helps minimise cycle times thereby enhancing the return on investment (ROI) of the LC-MS/MS system,” explained Stuart Phillips, Shimadzu UK’s LC/LCMS Business Manager. “The solution is also appealing for users of AB Sciex and Thermo Fisher Mass Spectrometers who either do not have a UHPLC capability or are struggling to integrate their existing HPLC or UHPLC systems with AB Sciex’s Analyst software or Thermo Fisher’s XCalibur software. Our no-compromise solution curbs the higher cost of analysis associated with lost runs when communications have failed and also removes the unnecessary complexity and system costs that some users face when they need to use more than one software platform to reliably run their LC-MS/MS system.”
Circle no. 46
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