21 UHPLC Front End System Perfect for LC/MS Analysis in Drug Detection Processes
Shimadzu has introduced the Nexera MP UHPLC as a Front End system for LC/MS. The Nexera MP is perfect for LC/MS analysis conducted in pharmacokinetics and synthesis stages in drug detection
processes.The new SIL-30ACMP Multiplate Autosampler used in the Nexera MP is best suited for LC/MS analysis and has the industry-best micro-volume injection repeatability, the world’s highest injection speed and the lowest carryover. Combining the Nexera MP with Shimadzu’s LCMS-8030 Triple Quadrupole Mass Spectrometer or the LCMS-2020 Single Quadrupole Mass Spectrometer creates a system for quick analysis of multiple samples with high accuracy.
Pharmacokinetics and candidate compound synthesis stages in drug discovery processes need fast analysis of multiple samples using an LC/MS system with high throughput. Minimisation of carryover in samples is also important for enhancement of LC/MS analysis reliability, since mass spectrometers are becoming more and more sensitive. The synthesis stage demands a system where two or more users can share an instrument and measure samples without delay, so that candidate compounds can be checked and identified quickly for more efficient analysis. This setup also reduces power consumption, thereby lessening the burden on the environment. Combined with high-performance accessories, the Nexera MP UHPLC Front End system achieves outstanding features: efficient sample preparation; multi-sample processing with the world's fastest injection; industry-lowest level carryover; two or more analysers share one system; and column oven setting to the MS position.
The Nexera MP is controlled by Shimadzu’s LabSolutions software and major LC/MS workstations available from other companies. Circle no. 58
Pittsburgh Researchers Combine Work On Novel Polymers For Drug Delivery
Molecular weight and molecular weight distribution measurements are a basic necessity in studying the synthesis of the novel polymers being carried out by researchers at the Department of Bioengineering at the University of Pittsburgh.
For the Pittsburgh team, the applications and technical expertise provided by Malvern Instruments is a significant factor in their use of the company’s Viscotek gel permeation chromatography (GPC) system to characterise polymer molecular weight, prior to applying the Zetasizer Nano for zeta potential measurements to study inter-molecular interactions.
Hunghao Chu, a graduate student in the Department of Bioengineering in Pitt's Swanson School of Engineering, synthesises new polymers to control the release of growth factors that regulate cell activity and body function. These novel molecular platforms are expected to have multiple applications in drug delivery.
“GPC is fundamental to our research,” said Hunghao Chu. “We have to fully understand our new polymers and GPC delivers absolute molecular weight measurement. We also need to know the polydispersity index of our samples to understand polymer homogeneity. When publishing data in peer reviewed journals it is very important to have confidence in results and to be able to validate them.”
“I am 100% satisfied with Malvern Instruments’ customer service,” continued Hunghao Chu. “While many instruments on the market appear to provide similar standards of data, good customer service is a highly important distinction. Malvern Instruments stands out in its provision of support beyond initial purchase. This means that we can be confident in the long term functionality of any system we buy from them.”
The Viscotek line of instruments offers a complete, temperature controlled, advanced, multidetector GPC system suitable for all macromolecular applications, particularly research.
The Zetasizer series measures particle and molecular size from below a nanometre to several microns, zeta potential, electrophoretic mobility, and molecular weight. In addition the system can be connected to a GPC system to enable it to be used as a chromatography detector.
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INTERNATIONAL LABMATE - AUGUST/SEPTEMBER 2011 - CHROMATOGRAPHY
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