Laboratory Products 57 New System for Lipid Nanoparticle Formulation
Knauer, the supplier of the lipid nanoparticle (LNP) production units, used by key pharmaceutical companies for their mRNA-based Corona vaccine production now offers a benchtop system, that is made for research and development as well as pre-clinical and small-scale production of lipid nanoparticles.
The IJM NanoScaler system is designed for lipid nanoparticle R&D - allowing scientists to determine the optimal process parameters for the formulation of API-containing lipid nanoparticles. These active pharmaceutical ingredients include complex or delicate API like RNA, mRNA, siRNA, and DNA-based molecules, or products that need specifi c entry into target cells.
Equipped with Knauer’s lipid nanoparticle producing Impingement Jets Mixing (IJM) technology the NanoScaler allows researchers to optimise encapsulation conditions for their nucleotide-based therapy before scaling up the process to run on a larger GMP-compliant IJM NanoProducer unit.
The IJM NanoScaler is made for low sample consumption so as not to waste valuable API. Its small footprint means it can comfortably sit on the benchtop of a research and development lab.
The system comes with fi ve different Knauer Impingement Jets Mixers to help researchers determine which conditions result in the optimum level of API encapsulation. In addition, researchers can use their own custom mixing unit and benefi t from the fl exibility of the system set-up.
The formulation process can be remotely controlled by software; ran from a conventional PC or laptop, or even a tablet.
The IJM NanoScaler enables the scouting of several key parameters during the lipid nanoparticle encapsulation stage: mixing unit geometries; mixing fl ow rates and ratios; varying lipid formulations; dilution protocols.
The IJM NanoScaler can be used to produce lipid-encapsulated API at a range from 1 mL to hundreds of millilitres meaning the system is perfect for proof-of-concept testing and process optimisation, pre-clinical trials e.g. for in vitro studies, as well as small- scale production.
More information online:
ilmt.co/PL/mKQj 57935pr@reply-direct.com
Viscosity is an important physical property to assess when developing products and materials such as polymers, inks, ionic liquids, pharmaceu�cals, foods etc. Using novel measurement technology, the electromagne�cally spinning viscometer EMS-1000S is ideal for measuring samples that are not measurable by conven�onal viscometers.
Small sample volume
As low as 300μL (standard tube) As low as 90μL (op�onal tube)
Accurate temperature control mechanism
Range: 0 to 200℃ Stability: ±0.1℃
Dependence studies
Se�ngs for the real �me analysis of temperature & shear rate dependence of viscosity.
Versa�le sample container
Disposable, autoclavable & can be herme�cally sealed. Sterile samples can be reused.
EMS Viscometer EMS-1000S
SMART VISCOSITY
MEASUREMENT BY INNOVATIVE TECHNOLOGY
h�ps://
www.kem.kyoto/
Compact 4-Position High Pressure Benchtop Reactor
The Quadracell 4-position high pressure reactor from Asynt is a new synthetic tool for scientists seeking the convenience of routine parallel pressure chemistry in a compact footprint. Designed and manufactured in the UK, the robust Quadracell reactor is simple to set up and to operate, with heating and agitation provided by a standard magnetic hotplate stirrer and magnetic fl ea.
Constructed in durable Stainless Steel 316, the Quadracell has four cells - each with a reaction volume of 10 mL - that can routinely operate at temperatures up to 250°C. For labs using aggressive or caustic media the Quadracell is optionally available constructed from Hastelloy C276 for enhanced chemical resistance.
Different versions of the Quadracell are available to safely operate up to your chosen maximum working pressure of 50, 100 or 200 Bar. Each Quadracell high pressure reactor is supplied as standard with a pressure release valve, pressure gauge, gas inlet and gas outlet via two stainless steel needle valves.
With a wide range of accessories available, you can tailor the package to suit your exact chemistry and laboratory setup or select a standard Quadracell turn-key solution that’s ready to use right away.
The Quadracell is a new addition to the comprehensive range of single and multi-position high-performance pressure reactors from Asynt. To download a fl yer providing a brief overview of the range please visit
ilmt.co/PL/AyZg
More information online:
ilmt.co/PL/vPoe 56150pr@reply-direct.com
Compact Benchtop Lab-scale Freeze-dryer
Telstar LyoBeta Mini is a compact (W94cm x H76cm x D63cm) pilot-scale freeze dryer specifi cally intended for small scale formulation, research, and development work. It has been designed in twin-vessel confi guration with a condenser capacity 6 Kg, which is separate from the product chamber. It belongs to the LyoBeta range of freeze dryers that encompasses advanced process control systems, management software, and interface features.
Taking up minimal bench space as well, the compact lab freeze dryer which offers the fl exibility, high performance, and small foot-print required in a laboratory unit, has been designed for applications in experimentation and formulation to develop recipes in pharmaceutical freeze-drying processes.
In addition, Lyobeta Mini is equipped with an automatic stoppering system that enables an automatic sequence to be programmed. This includes an electromagnetic aeration valve and piezo-pressure sensor for use in combination with the pneumatic stoppering device. This compact laboratory freeze-dryer offers 0.18m2 of useful shelf surface area with temperature control from -55 to +70°C. A cascade refrigeration system using CFC-free refrigerants cools the shelves and will reduce the temperature of the condenser up to -85°C.
Through the integration of a chamber-condenser butterfl y-type separation valve, a pressure rise test can be performed directly from the control system of the LyoBeta Mini, enabling determination of the end of the freeze-drying process. A PLC-based control system enables complete control of the process parameters, recipe programming, pressure, and temperature monitoring.
A broad range of options makes the Lyobeta Mini enable fl exible and customised confi guration fi tted to customer requirements to reach higher performance and process optimisation. Lyobeta Mini is considered a valuable tool in understanding the freeze-drying process and the associated parameters required for the process of production.
More information online:
ilmt.co/PL/OyBZ 58065pr@reply-direct.com
The latest news and products on your mobile device...
WWW.LABMATE-ONLINE.COM
Search: Labmate App or Scan here
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68
