Proteomics, Genomics & Microarrays
Polyspecifi c Antibodies for Cancer Research
AMSBIO announce a new range of high-quality bispecific antibodies (BsAbs) and trispecific antibodies (TsAbs) that can used to provide enhanced cancer therapeutic efficacy and/or safety compared to what can be achieved with conventional monospecific antibodies.
The concept of using a molecule with more than one binding site to enhance its biological function has been around for some time. Polyspecific antibodies are the basis of a new class of anti-cancer agents which offer the potential to be directed at multiple tumour antigens to eradicate tumour cells more precisely and effectively.
Polyspecific monoclonal antibodies are genetically engineered proteins that can simultaneously engage two or more different types of epitopes. There are many building block formats to generate BsAbs and TsAbs based on combining the antigen recognition domains of monoclonal antibodies (mAbs).
Bispecific antibodies and trispecific antibodies offer a range of advantages over monoclonal antibodies. This includes that they can redirect specific polyclonal immune cells such as T cells and NK cells to tumour cells to enhance tumour killing, or simultaneously block two different pathways with unique or overlapping functions in pathogenesis. Additionally, BsAbs and TsAbs potentially increase binding specificity by interacting with multiple different cell surface antigens instead of one, as well as reducing development and production costs when compared to multiple single based antibodies used in combination therapy or compared to the production of CAR-T cells.
Pre-clinical studies and early phase clinical trials have demonstrated that bispecific and trispecific antibody therapy offer improved treatment of solid tumour malignancies and highlights the potential they hold for future therapies to come.
More information online:
ilmt.co/PL/Wx2J 58012pr@reply-direct.com
Cas9 Protein for Clinical Genome Editing Research
A new GMP-manufactured Gibco CTS TrueCut Cas9 Protein has been launched by Thermo Fisher Scientific. TrueCut Cas9 proteins are manufactured with United States Pharmacopeia standards in mind, including traceability documentation, aseptic manufacturing and safety testing.
Providing consistent high-editing efficiency in all tested cell lines and greater than 90% efficiency in human primary T-cells, Gibco CTS TrueCut Cas9 Protein is a compelling solution for CAR T-cell therapy research using CRISPR-Cas9 genome editing. With the addition of a GMP-manufactured Cas9 protein and the recently launched Gibco CTS Xenon Electroporation System, Thermo Fisher can now support researchers across the autologous T-cell workflow.
“As genome editing quality and regulatory requirements continue to evolve, we are focused on providing solutions to meet scientists’ needs as they transition from the bench to the clinic,” said Brandon Pence, Vice President and General Manager of Cell Biology at Thermo Fisher Scientific. “By adding the Gibco CTS TrueCut Cas9 Protein to our portfolio of genome editing solutions, we can now support scientists in their journey to develop personalised CAR T-cell therapeutics.”
The Gibco CTS TrueCut Cas9 Protein is part of Thermo Fisher’s Cell Therapy Systems (CTS) product line, a comprehensive portfolio of GMP-manufactured products supported by traceability documentation. This product line is designed to work synergistically across the entire workflow, from cell isolation/activation to cell engineering and expansion, to address cell therapy developers’ manufacturing needs.
More information online:
ilmt.co/PL/4zXl 57821pr@reply-direct.com
Stackable Chilling Incubators for Protein Crystallography
The new EchoTherm™ Stackable/ Programmable Vibration Free Chilling Incubators from Torrey Pines Scientific are ideal for protein crystallography and other life science uses.
The incubators are 27 litre capacity and Peltier-based for heating and chilling. They have no compressors or CFCs and are vibration-free making them ideal for doing protein crystallisations. Other applications include incubating marine samples below room temperature, enzyme reactions and deactivations, hybridisations, ligations, storing oocytes, and general lab incubations. Three units may be stacked using two stacker accessories Model IN30-300.
The IN35 is a fully programmable unit that can store 3 programs in memory and features precise temperature ramping both up and down. Temperatures are settable from 4.0ºC to 70.0ºC controllable to ± 0.1°C, and accuracy to ± 0.2ºC. They have RS232 I/O port for remote control and data collection, digital timer in hours, minutes and seconds with user settable Auto-Off, and audible alarms. Chamber size is 12” high by 10” deep by 14” wide and comes with two stainless steel racks with room for four.
The units are shipped with universal power supplies for use anywhere in the world off local line voltages, AC line cord for the country of use, user manual and full 12-month warranty. They are UL, CSA, and CE compliant.
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