New Compact HPR-20 Gas Analyser Family
Hiden Analytical introduces the new HPR-20 range of application-specific
compact benchtop gas analysers for dynamic measurement of in-process gas composition. All systems feature precision quadrupole mass spectrometers with standard mass range options 200 and 300 amu, with mass range options from 20 to 1000 amu being available for specialised applications.
www.hidenanalytical.com
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www.Labmate-Online.com AI Meets Live Cell Imaging
Olympus’ newly launched scanR 3.1 high-content screening (HCS) station fully embraces the capabilities of artifi cial intelligence (AI) to enable cutting-edge life science research. It combines the modularity and fl exibility of a microscope-based setup with the automation, speed, throughput and reproducibility of HCS applications. Using the ‘self-learning microscopy’ concept, scanR 3.1 makes it easy to gather data quickly from large live cell populations for reliable, well-supported experimental results.
To minimise setup time, the self-learning approach makes use of a short, one-time training phase in which the software uses a quickly acquired set of images to generate ‘ground truth’ data without requiring human annotations. It then uses convolutional neural networks to autonomously create robust algorithms that can rapidly analyse large sets of images.
One application that clearly shows the power of AI in HCS is label-free quantifi cation of live cells. Olympus’ scanR HCS software can reliably derive nuclei positions in micro wells solely from brightfi eld transmission images, with an accuracy that rivals fl uorescence. Quantifying live cells from brightfi eld images instead of fl uorescence shortens exposure times, avoids using genetic modifi cations or nucleus markers, and saves fl uorescence channels for other markers. These benefi ts reduce phototoxicity and lead to simpler, faster image acquisition and better cell viability.
Reliable low light analysis has also become possible thanks to scanR’s AI-based imaging software. Olympus has shown that its software accurately detects DAPI- labelled cells at only 0.2% of the optimal light intensity. It can even distinguish different stages of the cell cycle, based on the intensity of the signal, providing better insights and improving reproducibility.
Dr Manoel Veiga, Application Specialist at Olympus Soft Imaging Solutions, commented on the launch, saying: “This exciting new scanR system is good news for a whole range of life science applications. Low light and label-free analysis are only examples of how automated detection using an AI-based approach can improve the accuracy and reproducibility of HCS. Olympus’ self-learning microscopy approach for scanR 3.1 combines these benefi ts with a user-friendly workfl ow that requires little human interaction during the training stage. This makes it easy for life science researchers to harness the power of HCS data while benefi tting from a fast, simple setup.”
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Temperature Control Catalogue 2020
Our new temperature control catalogue 2019/20 has been completely revised and shows a large selection of products for applications in laboratory, mini plant and production, including high dynamic temperature control systems, chillers as well as classical baths and circulators for working temperatures from -125 to +425°C.
Peter Huber Kältemaschinenbau AG Tel: +49-781-96030
Email:
info@huber-online.com
www.huber-online.com Specialty Optical Liquids From Cargille Laboratories
Cargille Laboratories name is synonymous with Refractive Index Liquids and Immersion Oils. We offer a variety of immersion oil formulations covering a wide spectrum of viscosities and fluorescence levels. In addition, we manufacture custom liquids for optical engineering.
We also offer a range of related instruments and lab products including viscosity tubes, disposable graduated polypropylene, disposable wood stirring rods and disposable glass test tubes.
We are proud to be of service to laboratories worldwide which utilise Specialty Optical Liquids, Immersion Oils, and Disposable Products.
Cargille Labs - Services to the Sciences since 1924
Please call or email to request a copy of our catalogue or view our full range on-line: Tel: (1) 973-239-6633, Email:
cargillelabs@cargille.com
www.cargille.com Fax: +49-781-57211
Freeze-Drying Microscope Generates Critical Formulation Specifi c Data
SP Scientifi c has video interviewed Dr Kevin Ward of Biopharma Process Systems Ltd, to discuss the key benefi ts of the Lyostat5 Freeze-Drying Microscope (FDM), and how it can be used to generate critical formulation-specifi c data. Every freeze-drying formulation has a critical temperature, below which it should be maintained during primary drying in order to prevent processing defects.
Dr Ward explains how using the Lyostat5 freeze drying microscope allows observation of the sample structure during drying and precise temperature control when cooling or heating so that the exact point of collapse can be determined. In addition, he describes how the Lyostat5 freeze-drying microscope lighting and image capture systems provide sharp visualisation for easy, accurate identifi cation of structural changes. Using the derived data, he explains how after analysis has been carried out that formulations and cycles can be developed that are safe, robust, and cost effi cient. Dr Ward summarises that for every 1°C higher a formulation can be freeze dried at, then results in an effi ciency saving of 13%.
The Lyostat5 freeze drying microscope is part of the SP Scientifi c Line of Sight™- enabled suite of freeze drying equipment and technologies portfolio. As well as enabling the determination of critical temperatures including eutectic melting temperature (Teu) and collapse temperature (Tc), the Lyostat5 freeze drying microscope also enables the identifi cation of crystallization phenomena, skin/crust formation, and the effects of annealing on ice crystal growth and solute structure. Knowledge of the critical temperatures is essential to conduct cycle development on a rational, quantitative scientifi c basis as well as saving precious resources in terms of time and monies needed. The Lyostat5 freeze-drying microscope is supplied fully validated as a complete working system against a series of standard solutions.
More information online:
ilmt.co/PL/rEWy 50906pr@reply-direct.com
WWW.LABMATE-ONLINE.COM
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