46


ADC Service to Accelerate Pre-clinical Conjugation Candidate Selection Announced Merck has introduced its ADC ExpressTM


services for the rapid production of ADCs, which can reduce the time needed to produce development


grade constructs for target molecule identification. With more than 70% of ADC projects outsourced to CDMOs, this crucial and streamlined service enhances Merck’s offering of process development, analytical development, testing services and manufacturing or supply of linkers, cytotoxins/payloads and conjugates. Merck is committed to working with ADC innovators to speed the delivery of potential new cancer treatments to patients. The company has been at the forefront of ADC manufacturing for the last decade and is one of the few CDMOs offering pre-clinical ADC development and other development and GMP services globally.


Merck’s established platform technology can efficiently turn an antibody, linker and payload into an ADC. The company offers a platform approach to ADC constructs and bioconjugation, resulting in increased flexibility and speed.


services include: mini-prep scale - 10–20 mg ADC construct ± column purification; medium-prep scale - ~100 mg ADC ± column purification; certificate of testing with key quality attributes, including ADC concentration, payload density/DAR (drug antibody ratio) and monomer/aggregate content and free residual payload.


ADC ExpressTM For companies that have a rich pipeline of monoclonal antibodies (mAbs) and want to enter the ADC space, Merck’s ADC ExpressTM services


allow them to obtain ADCs without having to invest in potent handling capabilities. Companies can either bring their own linker technology or procure a linker payload from Merck. Traditionally, several CDMOs across the globe were involved in the development and production of ADC programs. Merck’s comprehensive ADC service portfolio combines the crucial steps of drug development and production: mAb solutions, linker, payload and the final conjugation - all from a single source.


Merck has more than 35 years’ experience handling biological molecules and small molecules (including highly active or potent molecules), performing conjugation and complex analytical testing and manufacturing, reducing complexity for customers.


More information online: ilmt.co/PL/AROZ 50504pr@reply-direct.com


Temperature Control for Electromobility Test Processes


Bertrandt AG provides its customers with test stands with climatic chambers to test high-voltage batteries from the module level and hybrid batteries to batteries for all-electric vehicles under various climatic and load conditions. The components are exposed to a wide variety of conditions in climate simulations or accelerated aging in fatigue tests. This year the company built one of the largest high-voltage battery test centres in Germany in Ehningen. Bertrandt has put its faith in temperature control technology from Lauda to equip the new test chambers.


In addition, the company has ordered Process Cooling Units with volume flow control from Lauda which meet the high demands of customers in the automotive sector. The units are used to control the temperature of test specimens inside a climatic chamber, such as HV storage devices, i.e. high-voltage batteries, which are used in electric cars as well as solar systems. The customer uses two large SUK 400W units for performance tests and ten additional SUK 350W units for endurance tests and simulation runs. The Process Cooling Units precisely control the temperature from -40 to 120°C.


Lauda develops the refrigeration systems with a water/glycol mixture as the temperature control medium and a single-stage schema cooling circuit. By dispensing with a cascade refrigeration system, Lauda can guarantee the future-proofing of the design with regard to the European F-Gas Regulation, since a refrigerant with a high GWP value is not required for the second stage. The refrigeration system must have sufficient power reserves, in order to be able to guarantee precise control even at limit temperatures around -40°C. Each individual Process Cooling Unit must be precisely tailored, since water/glycol mixtures begin to freeze at temperatures around -45°C (depending on the concentration).


Lauda has equipped the Process Cooling Units with fully automatic filling and draining of the test specimen, in order to facilitate the testing processes of the customer in the automotive sector. This technology, which has been in Lauda’s product range for a long time, is now being requested by more and more customers and is becoming the industry standard, explained Manuel Faulhaber, Project Manager at Lauda Heating and Cooling Systems. Since Bertrandt is a service provider which serves a wide variety of customers, the systems have also been designed with fully automatic filling and draining of the entire system.


More information online: ilmt.co/PL/2OdE 50911pr@reply-direct.com


Fume Cupboard Range Combines Functionality and Operator Safety


In 1980, CSC began as fume extraction specialists before becoming a distributor of imported laboratory equipment. Focused on customer satisfaction, our founder, Noel Smyth became increasingly aware of the limitations imposed by standardised fume cupboards. He believed that the product should be built to suit the individual client and their specific needs. This eventually led to CSC’s progression into manufacturing.


To create a truly unique product, CSC’s R&D team selected PVC, a 100% recyclable and incredibly durable material. To ensure a superior product across the board, the team focused on the most important aspect of the cupboard, operator safety. The company’s design led the way to improved performance and as a result CSC’s ChemFlow Bench Mounted unit was the world’s first fume cupboard to receive the BS7258 Certification. The latest range, the ChemFlow 2020 Vision, is certified to the highest BS Standard, EN 14175.


CSC’s design and production teams can produce a wide range of fume cupboards to meet the function of the laboratory and safety of the users. For more information, contact sales@csc.ie. Interested in becoming a distributor? Contact info@csc.ie.


More information online: ilmt.co/PL/2Oy2 51272pr@reply-direct.com


pioneered the development of interchangeable ground glass joints in 1934. Over 85 years of experience and expertise in the processes and techniques required to manufacture jointed glassware to a consistently high quality has made Quickfit® exclusively from Pyrex®


Quickfit® Quickfit®


borosilicate glass, Quickfit®


solvents over a broad temperature range. Quickfit® Quickfit®


glassware is durable and safe to use in a wide range of lab applications, with a variety of acids, alkalis and joints continue to be manufactured in the UK, by SciLabware.


joints are first ground to a surface finish that meets the requirements of the international standard for ground joints, ISO 383. The joints are then subjected to a second grinding process that produces a joint with an exceptionally smooth surface finish that is half the tolerance specified in the standard. This unique manufacturing process creates a joint with a super-fine surface finish which is exceptionally leak-proof, vacuum-tight and provides a safe seal against potentially harmful chemicals and gases leaking from the joint. It also reduces the risk of joint seizure allowing the joints to be separated more easily.


Manufactured with a precision 1:10 taper, Quickfit® manufacturing processes, modern Quickfit®


The round rim profile of Quickfit®


conical joints are completely interchangeable with any other joints of the same size. Due to consistency in the joints are completely interchangeable with joints made decades ago.


conical socket joints provides additional mechanical strength and robustness that helps to prevent the socket cracking when an


assembly is used under vacuum and when it is assembled and disassembled. The round beaded rim is less prone to damage than the square rim profile used by other manufacturers (no corners to chip off) and helps to increase the service life of the joints.


More information online: ilmt.co/PL/2gwk 50380pr@reply-direct.com


- Still Making The Right Connections the number one choice for scientists around the world. Manufactured


INTERNATIONAL LABMATE - FEBRUARY 2020


Page 1  |  Page 2  |  Page 3  |  Page 4  |  Page 5  |  Page 6  |  Page 7  |  Page 8  |  Page 9  |  Page 10  |  Page 11  |  Page 12  |  Page 13  |  Page 14  |  Page 15  |  Page 16  |  Page 17  |  Page 18  |  Page 19  |  Page 20  |  Page 21  |  Page 22  |  Page 23  |  Page 24  |  Page 25  |  Page 26  |  Page 27  |  Page 28  |  Page 29  |  Page 30  |  Page 31  |  Page 32  |  Page 33  |  Page 34  |  Page 35  |  Page 36  |  Page 37  |  Page 38  |  Page 39  |  Page 40  |  Page 41  |  Page 42  |  Page 43  |  Page 44  |  Page 45  |  Page 46  |  Page 47  |  Page 48  |  Page 49  |  Page 50  |  Page 51  |  Page 52  |  Page 53  |  Page 54  |  Page 55  |  Page 56  |  Page 57  |  Page 58  |  Page 59  |  Page 60  |  Page 61  |  Page 62  |  Page 63  |  Page 64  |  Page 65  |  Page 66  |  Page 67  |  Page 68  |  Page 69  |  Page 70  |  Page 71  |  Page 72  |  Page 73  |  Page 74  |  Page 75  |  Page 76  |  Page 77  |  Page 78  |  Page 79  |  Page 80  |  Page 81  |  Page 82  |  Page 83  |  Page 84  |  Page 85  |  Page 86  |  Page 87  |  Page 88