Chromatography 9 Improve Acrylamide Analysis with a Longer-Lasting LC Column
The porous graphitised carbon (PGC) columns typically used for acrylamide analysis by method EN 16618:2015 provide adequate retention of acrylamide and sufficient separation from matrix components, but they are subject to long run times and short column lifetimes. Switching to an Allure Acrylamide LC column is a better alternative: an Allure Acrylamide column used with a deuterated internal standard provides faster total analysis times and meets system suitability requirements longer.
Allure Acrylamide columns meet the EN method 1.7-minute retention time requirement with good separation from matrix components and a much shorter equilibration time. A per analysis savings of 2.5 minutes allows more samples to be analysed per shift, significantly increasing lab output. In addition to faster run times, testing showed that the Allure Acrylamide column passed the 1.7-minute system suitability requirement for over twice as many injections as a typical PGC column.
Developed to withstand 100% aqueous mobile phases and elute coextracted matrix components rather than strongly retaining them, Restek Allure Acrylamide guard and analytical columns deliver the same robust performance injection to injection and column to column, making them a more reliable choice for acrylamide analysis, even in difficult food matrices like potato chips or coffee.
More information online:
ilmt.co/PL/k0xA 50700pr@reply-direct.com
Cutting-edge Software Functionalities for U(H)PLC Modelling at PittCon 2020
PittCon is one of the world’s leading conference and expo on laboratory science and this year will take place from 1-5 March at McCormick Place, Chicago, Illinois.
Molnár-Institute team will present the latest applications of the DryLab® modelling liquid chromatographic separations at booth 3814.
software in
Recent development in integrating Empower CDS includes 3-level automated steps in software’s AQbD-workflow by creating, performing and retrieving input runs, model- verification and robustness verification experiments. Generated method sets are being performed in most economic and ecologic order, also taking into account subsequent equilibration steps. This provides an easy modelling platform for making science-based flexible method development choices, mitigate risk, improve analytical throughput and ultimately deliver method development success.
Molnár-Institute will also contribute to the technical program by presenting an oral lecture on the potential for Green Analytical Chemistry by Modeling UHPLC, showing how scientific retention modelling contributes significantly to reducing the environmental footprint of analytical chemistry.
Stop by booth 3814 to discuss innovative strategies for improving the efficiency and success of cutting-edge HPLC through the revolutionary method development software, DryLab®
4.
More information online:
ilmt.co/PL/p0rB 51194pr@reply-direct.com
How to Overcome the Limits of HPLC with Ion Chromatography
What’s the difference between High Pressure Liquid Chromatography (HPLC) and Ion Chromatography (IC)? What are the capabilities and limitations of each technique? Knowing these differences can actually make a huge difference. As a proven, robust and highly versatile technique, IC can help HPLC users extend their analytical capabilities tremendously. Metrohm’s free white paper compares the two methods systematically focusing on the strengths of ion chromatography.
HPLC is one of the most powerful analytical techniques in the modern laboratory. From research to manufacturing to legal, it is widely used in many sectors. However, there are some inherent limitations. Ionic and polar compounds pose a challenge. So do organic acids. Moreover, some analytes such as, e.g., fluoride and chloride are not active in the UV range, making it impossible to determine them with a UV
detector, the detection technique most commonly used with HPLC. Ion chromatography (IC), on the other hand, is ideal for the separation and detection of ions and polar molecules, both organic and inorganic. This makes IC the ideal extension of HPLC increasing the analytical capabilities of the modern laboratory tremendously.
Over the last 30+ years, Metrohm has made Ion Chromatography a powerful tool for both research and routine analysis. Laboratories in the pharma, food, and water sectors in particular benefit not only from the method itself but from many automated inline sample preparation and injection techniques. Samples with a high load of particles (e.g., wastewater), solid and even gaseous samples can be analysed fully automatically down to the µg/L range with superior reproducibility. Hundreds of IC applications are available free of charge from the Metrohm Application Finder and users are supported in more than 120 countries by application specialists from the local Metrohm sales organisations.
More information online:
ilmt.co/PL/Z3Ja 50852pr@reply-direct.com
NDMA in Drugs 800 Series TEA
The Ellutia 800 Series TEA can be interfaced to a chemical stripping system to quickly monitor ATNC (Apparent Total N-nitroso Content) and interface to a Gas Chromatograph to indentifiy and quantify any volatile nitrosamines present such as NDMA.
Test For
Solutions for the analysis and screening of Nitrosamines in Pharmaceutical Drugs
The Use of Gas Chromatography to Test for Traces of Explosives
Chromatography can be an extremely valuable tool in the detection of explosives. Following an explosion, it is crucial to a police investigation to identify if an explosive was used, and if so what type. Finding traces of explosives on a suspects clothing or belongings can link that suspect to a case. Once trace samples are collected, the amount of explosives in the sample can be on the low nanogram range.
TEA detectors, coupled with GC are widely used for the forensic analysis of trace explosives. Its simple operation, very high sensitivity and very high selectivity for nitroso compounds, makes the TEA a superior choice of detector for this application.
The Ellutia 800 series TEA is already being used in the world class Dubai Police science and criminology laboratory, and a detailed case study can be found on Ellutia’s website.
More information online:
ilmt.co/PL/pZ9v 48648pr@reply-direct.com
To find out more visit
https://www.ellutia.com/nitrosamines-in-drugs
email:
info@ellutia.com tel: +44 (0)1353 669916
WWW.LABMATE-ONLINE.COM
Page 1 |
Page 2 |
Page 3 |
Page 4 |
Page 5 |
Page 6 |
Page 7 |
Page 8 |
Page 9 |
Page 10 |
Page 11 |
Page 12 |
Page 13 |
Page 14 |
Page 15 |
Page 16 |
Page 17 |
Page 18 |
Page 19 |
Page 20 |
Page 21 |
Page 22 |
Page 23 |
Page 24 |
Page 25 |
Page 26 |
Page 27 |
Page 28 |
Page 29 |
Page 30 |
Page 31 |
Page 32 |
Page 33 |
Page 34 |
Page 35 |
Page 36 |
Page 37 |
Page 38 |
Page 39 |
Page 40 |
Page 41 |
Page 42 |
Page 43 |
Page 44 |
Page 45 |
Page 46 |
Page 47 |
Page 48 |
Page 49 |
Page 50 |
Page 51 |
Page 52 |
Page 53 |
Page 54 |
Page 55 |
Page 56 |
Page 57 |
Page 58 |
Page 59 |
Page 60 |
Page 61 |
Page 62 |
Page 63 |
Page 64 |
Page 65 |
Page 66 |
Page 67 |
Page 68 |
Page 69 |
Page 70 |
Page 71 |
Page 72 |
Page 73 |
Page 74 |
Page 75 |
Page 76 |
Page 77 |
Page 78 |
Page 79 |
Page 80 |
Page 81 |
Page 82 |
Page 83 |
Page 84 |
Page 85 |
Page 86 |
Page 87 |
Page 88
