47 Rationally Designed Research Tool for Stable Expression of Mature MicroRNA
Thermo Fisher Scientific, Inc launched a new product for the long-term over-expression of mature microRNA. Thermo Scientific miRIDIAN shMIMIC Lentiviral microRNAs incorporate innovative design strategies that allow consistent processing of the mature microRNA and enhanced specificity, making them ideal for a variety of microRNA research applications.
miRIDIAN® shMIMIC™ Lentiviral microRNAs can induce stable over-expression of functional mature microRNA mimics by harnessing the endogenous
microRNA processing pathway. The shMIMIC microRNA is effectively delivered into the cell using purified, high-titer lentiviral particles; this facilitates delivery even in difficult-to-transfect cell types such as primary cells, stem cells and non-dividing cell types. The shMIMIC microRNA is then processed in the same way as an endogenous microRNA gene, resulting in over-expression of the microRNA mimic and subsequent down-regulation of the microRNA target gene(s).
shMIMIC Lentiviral microRNAs incorporate unique design elements that are critical for accurate processing and efficient downstream activity of only the mature microRNA of interest while minimizing the effects of the star (*) strand. shMIMIC lentiviral microRNAs have been effectively used by Thermo Fisher Scientific scientists to produce phenotypic responses to microRNA target gene down-regulation. Such studies provide valuable insight into microRNA participation in critical biological and disease pathways.
shMIMIC Lentiviral microRNAs are available in high-titer, purified lentiviral particle format for each human microRNA in the miRBase microRNA database. These unique, transduction-ready microRNA tools are ideal for phenotypic studies, drug discovery applications or to further studies of microRNA biology.
Circle no. 184
Budget Priced Laboratory Temperature Control Machines
Specialists in temperature control, Huber has expanded their product range of laboratory temperature control machines with the Microprocessor Controller. The MPC®
is a modern, low cost controller which has been purposely designed with basic functions. It can be purchased alone, as an
immersion bath or re-circulation temperature control machine. All models use natural refrigerants, are environmentally friendly and save energy. The MPC®
range feature an RS232 interface and an external PT100 connection.
models are suitable for countless laboratory uses, such as sample preparation, analysis, material testing, as well as external temperature control of measuring instruments or experiments. Bath volumes are from 2 to 25 Litres. Refrigerated baths fitted with the MPC®
Circle no. 185 Controllers
generate up to 350 watts of cooling power, depending on the model and cover a temperature range of -30°C to 200°C. The heating power is 2.0Kw for all models. ‘Advanced’ models in the MPC®
ADVERTORIAL Ultrameter II With all new features and functions…
The Ultrameter II still delivers the most accurate dissolved solids measurements of any instrumentation and the greatest degree of accuracy available for pH, ORP and Temperature measurements, but has been redesigned to include an LSI/Hardness Calculator, Free Chlorine Measurements and Bluetooth®
data transfer with
the optional bluDock™ accessory. The LSI calculator makes it easy to analyse the scaling nature of water in the lab or in the field. The calculator computes the saturation index of a sample based on measured and inferred values for pH, temperature, hardness and alkalinity.
You can then change any of these values in user adjust mode to analyse the effect of the change on water balance. User mode also allows you to input measured values for alkalinity and hardness as determined by other independent testing for a precise saturation index value. Within the LSI Calculator is a Hardness calculator that allows you to select either ppm or grains of hardness units.
Free chlorine measurements are mathematically derived from Oxidation Reduction Potential measurements. The mV to ppm free chlorine conversion algorithm is based on a published conversion curve and bench testing performed at the Myron L Company. With this new feature Myron L instruments can measure a dynamic range of sanitiser concentrations that is wider than the range of a colorimetric test kit.
With the bluDock™ accessory package, the Ultrameter II can now also transfer data wirelessly using Bluetooth®
technology. The Ultrameter II also
features KCl, NaCl, 442™ and User-defined solution modes for proper solution modelling in diverse applications. Autoranging allows instrument to maintain resolution for solutions with widely varying concentrations. The pH/ORP sensor is user replaceable and can be calibrated to 1, 2 or 3 points depending on requirements. 4-wire conductivity cell construction, extremely stable circuitry and proprietary conversion algorithms deliver reliable repeatable results.
Ultrameter II is compact, portable, waterproof and buoyant, easy to calibrate and easy to use.
Call the Myron L Company today to see why customers are saying this is the instrument they've been waiting for.
Circle no. 186 Circle no. 187
www.myronl.com INTERNATIONAL LABMATE - OCTOBER/NOVEMBER 2010 - LABORATORY PRODUCTS bluDock Enabled
NEW! bluDock™ Wireless Data Transfer (optional)
LAB ACCURACY AT THE TOUCH OF A BUTTON
NEW! LSI and Hardness Calculator
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