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Liquid handling workstation automates tropical disease research The Clinical Pharmacology Department in the Mahidol-Oxford Tropical Medicine Research Unit (MORU), Bangkok, Thailand, has chosen Tecan’s Freedom EVO®
to automate research into the pharmacology of anti-malarial and anti-influenza drugs.
Professor Niklas Lindegardh, Head of Department, explained: “Our studies focus on malaria and influenza, and the main thrust of our research is the development of new methods and assays to quantify these drugs in biological fluids. Our Freedom EVO liquid handling workstation performs aliquoting and preparation of patient samples, automating a range of preparation methods, such as solid-phase or liquid-liquid extractions and protein precipitations. We have been able to move from performing all these steps manually to automating everything on the Freedom EVO 200, and analyses that previously took around five hours now take only 20 minutes for 96 samples.”
“The platform configuration was tailored to fulfill our exact requirements and we worked with engineers from Tecan Singapore to set up the system and program the basic structure of the process scripts. We have since been able to refine the scripts, creating new processes and fine tuning the system to accommodate our sample preparation requirements. Overall, the platform is reliable and we are very happy with the support we receive from Tecan; they always respond quickly to our needs,” concluded Professor Lindegardh.
Circle no. 94 ADVERTORIAL
Economical and Quality Dissolution Apparatus from Labindia Instruments Pvt Ltd
New Rapid Cardiac Biomarker Test for the Management of Heart Failure
The Tablet Dissolution systems model DS 8000 and DS 14000 are used to analyse dissolution rate of tablets, capsules and other dosage forms. These systems conform to the latest norms as per USP, BP and other pharmacopeia’s specifications and ASTM methods described for Dissolution.
platform
Alere International has announced the launch of its new Triage®
NT-proBNP test. Used in conjunction with clinical
assessment, the NT-proBNP (N-terminal pro b-type natriuretic peptide) test is a useful biomarker in the diagnosis and management of patients with heart failure. The new test expands Alere’s market leading point of care Triage®
cardiovascular testing solutions.
Heart failure can often be confused with other conditions, such as lung disease, which is why an accurate diagnosis is important to ensure the most appropriate treatment and care is in place. BNP (b-type natriuretic peptide) and NT- proBNP levels can help doctors differentiate between heart failure and other problems, since the level of natriuretic peptides in the blood increases as chronic heart failure advances.
The Alere™ Triage NT-proBNP test can aid clinical professionals: diagnosing individuals suspected of having heart failure; assessing the risk of patients with heart failure; assessing the risk of patients with acute coronary syndrome (ACS); and assessing the increased risk for cardiovascular events and mortality in patients with stable coronary artery disease (CAD) who are also at risk of heart failure.
“Alere remains committed to the development of tools to manage cardiovascular care,” explained Colleen Hobbs, Global Product Director, Heart Failure. “The addition of NT- proBNP to the Triage family further supports our approach. Alere is proud to be the first manufacturer to offer both assays, BNP and NT-proBNP, on a point-of-care system, offering our customers convenience in choosing the test that is right for their practice setting.”
The Alere Triage NT-proBNP Test is CE marked, which expresses conformity with the requirements of the European IVD Directive and allows distribution within the European Union. The test is now available for commercial sale in Europe and will soon be available in many other countries around the world. A timeline for USA availability will be established shortly.
Circle no. 95
Dissolution studies involve 60 percent automated operations and 40 percent manual operation. Lab India Dissolution systems have been designed to minimise the manual errors by automation of the manual operations done in a dissolution process.
The conventional model DS 8000 with its (6+2) configuration allows simultaneous dispensing of tablets by means of a specially designed tablet dispenser. It is equipped with an intelligent sampling system comprising of the bidirectional 12 channel capacity Ismatec (SWISS make) peristaltic pump that carries out automated sampling as per USP Specifications with simultaneous media replenishment. It facilitates dissolution test using two buffers (buffer changing) specially to cater to the application of enteric coated tablets. The RTD Temperatures Sensor measures and records temperature of individual vessel at Zero interval and also at specified sample points. It allows sample collection of 6 sets using different capacities of vials. (5ml, 10ml, 15ml). So as to reduce contamination, it has the facility to rinse the entire sampling path in between sampling and specially developed cleaning system to clean the entire sampling path after each run.
The DS 14000 model (6+1, 6+1) includes above features and has been designed with R&D in mind such that comparative studies can be carried out wherein 6 bowls can be used for the research drug and 6 bowls for the comparator drug.
Conical shape evaporation recovery lid reduces media loss during long run. Also it is equipped with recovery test facility to study 100 % Drug Dissolution and has a software for calculating % D using individual tablet weight.
For more information about our products, please visit
www.labindia.com.
Circle no. 96 Circle no. 97
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