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LABORATORY PRODUCTS
Rely on CARVER Laboratory Presses
The world’s most popular lab presses with more choices, more features, more performance. Select from two-column and four-column benchtop, floor stand- ing, manual and automatic hydraulic presses with clamping capacities from 12 to 100 tons. Auto Series presses feature integral power and user friendly micropro- cessor based controls. Heated platens with digitally controlled cartridge heaters, plus a wide array of accessories for dedi- cated applications, let you choose just the right press for your needs. Contact us for complete information.
15 ton
Model 3889 (Auto "C") with heated platens, digital tempera- ture controllers
New Dissolution Tester has the Edge in Enhanced Mechanical Calibration
Copley Scientific has launched the Dissolution Tester DIS-EMC, a new system that features Enhanced Mechanical Calibration, and which is designed to meet the latest and most rigorous calibration needs in this field. State-of-the-art manufacturing procedures bring new standards in controlling the tolerances and dimensions of the critical elements of the Test Station in which the dosage form resides. In line with current regulatory guidance, this significantly reduces the potential of the dissolution tester to contribute to testing variability.
While accepted practice in the pharmaceutical industry has been to calibrate dissolution testers using a combination of mechanical checks and performance verification tablets, there is concern about the wide acceptance ranges and variability these generate. As a result the move is towards enhanced mechanical calibration as an alternative, or at least as a precursor, to chemical calibration.
12 ton manual Model 3851 (Model C)
Carver, Inc., 1569 Morris Street, P.O. Box 544
Wabash IN 46992-0544 USA • Tel: 260-563-7577 Fax: 260-563-7625 E-mail:
carverpress@corpemail.com Inter net:
www.carverpress.com
Circle no. 133
Enhanced mechanical calibration requires strict control of the dimensions of, and the spatial relationships between, critical elements of the dissolution tester. Copley Scientific has identified these critical elements to be the dissolution vessel and lid, and the stirring element. Controlling these, while also maintaining stirring speed and media composition and temperature within tight limits, minimises any instrument contribution to test method variability. Using vacuum forming techniques, Copley Scientific has produced a vessel with superior dimensions and which has provided a platform for the development of a new lid and stirring element. This production method guarantees an internal diameter tolerance and blemish-free spherical radius of +/- 0.13 mm (compared with the traditional unit’s +/- 2 mm). Friction-free bearings in the lid and a precision-ground shaft for the stirring element have enabled a 50% reduction in tolerances relating to wobble, verticality and centring. The Dissolution Tester DIS-EMC betters the dimensional tolerances specified by the FDA by a factor of 2.
Circle no. 134
Perfect Clarity for Alcohol Fermentation
Stratophase is providing a vital insight into the fermentation of alcoholic beverages with its SpectroSens technology. This technology uses refractive index and temperature measure- ments to provide real-time, online monitoring of this complex and time dependent process, and is currently performing very well in external trials to assist with quality control.
The production of alcoholic beverages such as beer, wine and spirits, relies on fermentation. This process however, is impacted by the seasonal variability in crops, which makes the critically important step of maintaining quality very difficult. The high sampling rate of the SpectroSens allows for additional kinematic data to be captured in addition to the overall refractive index and temperature profiles, thereby enabling key points within the fermentation process to be easily identified.
Circle no. 135 Circle no. 136
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