12
TLC to MS – Direct and Rapid
Not all samples may be processed by HPLC- MS. In the past unknown substances were then scraped off from the TLC plate, eluted into a tube and transferred in the MS. Now the convenient and universal Camag TLC-MS Interface is available which semi-automatically extracts zones of interest and directs them online into all common brands of LC-coupled mass spectrometer or extracts them into vials for NMR or (ATR-)FTIR, static nanospray, direct inlet El-MS and MALDI. The interface extracts the complete substance zone with its depth profile and thus allows detections comparable to HPLC down to the pg/zone ranges. The interface has been proven to be one of the most reliable and versatile interfaces for TLC/HPTLC-MS coupling.
Circle no. 14
CHROMATOGRAPHY & SPECTROSCOPY
ICP-MS Systems Help Ensure Safety of Chinese Herbal Medicines
PerkinElmer, Inc announced that the Company’s Inductively Coupled Plasma-Mass Spectrometer (ICP-MS) technology can help insure that traditional Chinese herbal medicines comply with safety guidelines. Amid concerns that traditional herbal ingredients may contain potentially toxic contaminants, PerkinElmer’s broad portfolio of high performance analytical solutions are well suited for the safety and quality testing of traditional Chinese herbal medicines. PerkinElmer’s ICP-MS systems, such as the ELAN 9000, offer exceptional analytical sensitivity and accuracy and feature superior detection capacity. Traditional Chinese herbal medicines are generally perceived by consumers as being natural and having few side-effects. Due to the complexity of the medicinal plants, their inherent biological variation and environmental influences, it is essential to evaluate the safety, efficacy and quality of these herbal ingredients to ensure consumer safety.
Awareness of the potential for contamination has led to the increased demand for quantitative evaluation of inorganic impurities. The Chinese Pharmacopoeia 2010 (CP 2010) guidelines, due to take effect later this year, will set legal limitations on the levels of certain critical elements, including lead and arsenic, in medicinal products intended for frequent use by infants and the elderly. PerkinElmer’s range of ELAN ICP- MS instruments, as well as the new NexION 300 ICP-MS offering, which both combine superior detection limits with ease of use and high sample throughput, can help to assess traditional Chinese herbal ingredients for CP 2010 compliance. Designed for the quantification of elemental isotopic concentrations and ratios, PerkinElmer’s ELAN ICP-MS range offers multi-element capacity, allowing the detection of multiple analytes per sample to enable quicker analysis. Operating at or below the parts-per-trillion detection range, ELAN ICP-MS systems can provide the levels of sensitivity and reproducibility necessary for the accurate determination of the inorganic profile of Chinese herbal medicines.
High-Speed Separations
Circle no. 16
Detecting Bisphenol A in Food & Beverage Containers
Chiral Technologies Worldwide offers immobilised and coated chiral stationary phases (CSP) in 3-µm particle size. These 3-µm CSPs - CHIRALPAK®
IA, CHIRALPAK IB, and
CHIRALPAK IC, CHIRALPAK AD, CHIRALPAK AS, CHIRALCEL®
OD and CHIRALCEL OJ - offer
fast analysis time, while maintaining column resolving power when compared to larger particle CSPs.
Columns packed with 3-µm CSP can produce very high-speed separations, which will result in processing more samples per day,
while
reducing analysis time and cost per sample. They may be used in conventional HPLC units without significant loss in performance. Chromatographers can use Chiral Technologies’ 3-µm columns in reversed-phase, normal-phase and supercritical fluid chromatography modes.
CHIRALPAK and CHIRALCEL CSPs are also available in 5µm and 10µm particle sizes.
Circle no. 15
With Senator Dianne Feinstein (D-California) introducing legislation, as early as next week, to ban Bisphenol A (BPA) from being used in food and beverage containers, Dionex Corporation has already developed a fast accurate screening method for detecting BPA in food and beverage containers. The US FDA has been concerned about the negative health effects of BPA as studies have increasingly linked BPA exposure to a wide range of health disorders ranging from obesity, reproductive issues, cancers, and abnormal brain development, particularly in at-risk populations, such as children and infants. To monitor and reduce human exposure to BPA and structurally related compounds, analytical methods are necessary that can be performed rapidly and with the required selectivity and sensitivity required for quantitative analysis. Dionex Corporation has demonstrated several applications, including the recovery of BPA from canned tuna and phenols in drinking water. Additional methods using ultra-sensitive mass spectrometric detection have been developed for rapid automated testing for BPA without sample preparation or preconcentration, and utilised for the testing of bottled water, consumer products, and infant feeding bottles.
Circle no. 17 GC Analysis Made Simple
A new and improved version of GC Image and GC Project is now available. GC x GC is the best way to analyse the vast majority of gas chromatographic samples. GC Image and GC Project Software simplifies and automates the process for analysing GC x GC data. GC Image R2.1 introduces new and improved features, including: GC Image Investigator - allows users to analyse multiple chromatograms interactively. Examine both statistical characteristics and trends on multiple chromatograms, blobs, areas and blob sets; Batch Mode for performing library searches - improves performance up to ten times faster than interactive mode; Mass Calibration Tool - performs local mass calibration based on chromatographic peaks across the chromatogram; Formula Calculator - computes possible elemental compositions in high resolution mass spectrometric data; and Graphics and Meshes Editing Tools.
Take advantage of Zoex introductory discount of 25% to upgrade an existing license to R2.1 and obtain service and support for 12 months. Offer valid until June 30th
, 2010. Circle no. 18
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