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MORE PRODUCTS FROM METROHM
Simultaneous Determination of Gamma-Hydroxybutyric Acid (GHB) and Gamma-Butyrolactone (GBL) in Beverages
Drug Facilitated Crime (DFC) and Drug-Facilitated Sexual Assault (DFSA) in particular have become threats to partygoers in nightspots in many places. Prosecution depends on the successful detection of gamma-hydroxybutyrate (GHB) and its prodrug gamma-butyrolactone (GBL), the substances most commonly used to spike beverages to make the victim defenceless. Metrohm offers a straightforward and fast ion- chromatographic method to determine both substances in a single run.
For the forensic determination of illegally added GHB and GBL in commonly consumed beverages, this method employs direct-injection ion chromatography combined with spectrophotometric detection. In the range of 10 to 200mg/L, five-point calibration curves for GHB and GBL yield correlation coefficients of 0.9998 and 0.9997, respectively.
Spiking experiments in which GHB and GBL were added to alcoholic beverages and non-alcoholic fruit juices showed no matrix effects. The method allows to trace GHB-GBL interconversion, whether in-vivo or in-vitro lactone cleavage or intramolecular GHB esterification, and thus complies with pertinent requirements of law enforcement agencies.
Circle no. 24
889 IC Sample Center: High-Speed Automation for Small Sample Volumes (1 µL…10 mL)
Laboratory automation in the fast lane: With Metrohm’s new 889 IC Sample Center, less than 10 seconds elapse between start of determination and sample injection. This new and robust x-y-z autosampler has been designed for small sample volumes (1µL… 10mL) in particular. Moreover, it is available with a cooling function making it ideal for critical samples from the biochemical and clinical field that need to be kept stable over extended periods of time. The 889 IC Sample Center is highly versatile. Various injection methods can be selected: full-loop, partial-loop and pick-up. For all three modes, users can select injection with Pressure- Assisted Sample Aspiration (PASA™), a great advantage especially when viscous samples need to be analysed. Standard accessories of the 889 IC Sample Center include two 48-position-sample-racks for 300 and 700µL vessels. Injection volumes from 1 to 100µL (with 1µL increments) can be selected. Other sample racks that are common in liquid chromatography or SBS standard microtiter plates can also be used on the 889 IC Sample Center. The system supports sample racks with 12 to 384 positions. The 889 IC Sample Center is also available with a cooling function. In this version a Peltier element ensures that samples are cooled to a stable minimum of 4°C. Because of the sophisticated cooling system no temperature gradient can develop; a constant temperature is guaranteed.
Circle no. 25
New Generation of Microbore Colums for
Environmentally Friendly Anion Chromatography New legislation such as the ‘Clean Air and Water Act’ and a general trend towards green chemistry stipulate the use of environmentally friendly chemical products and processes. Metrohm responds to this introducing a new generation of high capacity anion exchange columns. The new columns feature an inner diameter of only 2mm enabling lower eluent flow rates and less solvent consumption. Moreover, environmentally benign carbonate/bicarbonate solutions are used with the columns for most anion separations. Not only the columns got thinner but also the suppressor module was scaled down, leading to reduced consumption of regenerant solution: for complete regeneration, as little as 2mL acid (1 mol/L) is sufficient and no exchange of cartridges or membranes is necessary. Besides the ecological benefits, microbore columns require less frequent eluent preparation and thus improve accuracy and save time. Additionally, they get along with only small amounts of sample material and can be perfectly interfaced with various inline detectors.
Circle no. 26 New Metrohm Brochure and Website “Pharmaceutical Analysis”
No other industry is as thoroughly regulated as the pharmaceutical industry. The active ingredients are legion and so are the standards to test for them. Metrohm’s new brochure, ‘Pharmaceutical analysis’, is a highly valuable compendium to get an overall view of the most important parameters determining the quality of pharmaceuticals and the methods best suited to check them.
‘Pharmaceutical analysis’, which can be ordered free of charge, draws on Metrohm’s comprehensive expertise in assuring the quality of pharmaceuticals. Using the U.S. Pharmacopeia as a reference, the new brochure covers basic general parameters such as pH value, conductivity and water content as well as the determination of specific active ingredients, excipients and impurities.
Methods described include potentiometric, colorimetric and Karl Fischer titration, ion chromatography, stability measurement, voltammetry, atline and online process analysis.’Pharmaceutical analysis’ is an invaluable tool for anyone who is involved in the professional quality assurance of pharmaceutical products. Metrohm’s complete know-how on pharmaceutical analysis is also available on the webpage
pharma.metrohm.com
Circle no. 27
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